Response to Aerobic Exercise in Patients with Pulmonary Hypertension

肺动脉高压患者对有氧运动的反应

• 批准号: 8565368
• 负责人: Leighton Chan
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8565368
• 关键词: Address; Adverse event; Aerobic; Aerobic Exercise; Affect; American; Anaerobic Threshold; Award; Behavioral; Cell Respiration; Characteristics; Chest; Classification; Complex; Conflict (Psychology); Control Groups; Data; Drops; Education; Employee Strikes; Energy Metabolism; Enrollment; Exercise; Exercise stress test; Fatigue; Goals; Guidelines; Interstitial Lung Diseases; Intervention; Knowledge; Left; Life; Manuscripts; Measures; Mediating; Medical; Metabolic; Modality; Muscle; Oxygen; Oxygen Consumption; Pathogenesis; Patient Self-Report; Patients; Performance; Peripheral; Pharmaceutical Preparations; Pharmacological Treatment; Physical activity; Physicians; Population; Protocols documentation; Psychophysiologic Disorders; Publishing; Pulmonary Hypertension; Pulmonary artery structure; Randomized; Rehabilitation Outcome; Rehabilitation therapy; Reporting; Research; Research Personnel; Rest; Risk Factors; Schedule; Societies; Sports Medicine; Symptoms; Syndrome; Systolic Pressure; Test Result; Testing; Time; Training; Training Programs; Translating; Treatment Protocols; Walking; Work; Workload; World Health Organization; abstracting; base; clinical practice; college; experience; functional disability; health related quality of life; healthy volunteer; improved; indexing; interest; meetings; psychosocial; response; standard measure; symposium; volunteer

PH patients participating in exercise training (EXE) showed significant improvement in the six-minute walk test distance, cardiorespiratory function measures and patient-reported health-related quality of life compared with their education only (EDU) counterparts. While the number of ILD patients is still small, similar improvements were also observed. Comparison of both PH and ILD patients to healthy control volunteers demonstrates the level of functional impairment experienced by these patients on a daily basis. The increased number of total patients in all groups (PH, ILD and healthy volunteers) has allowed us to present preliminary findings for this study. In October 2011, we presented data on the PH group at the annual meeting of the American College of Chest Physicians. This study was awarded the Alfred Soffer Research Award for outstanding original research presented during this meeting. Several other abstracts were also recently presented at the annual conference of the American College of Sports Medicine in May 2012 and the American Psychosomatic Society in March 2012. The first manuscript emanating from this research will be published by Chest shortly (accepted and in press). There are several more manuscripts in progress that are expected to be published within the year. Although the exercise training volume and intensity have been well tolerated by most of the patients, some have decided to withdraw from our study. To date, one patient withdrew because the minimum number of exercise training sessions could not be met; one withdrew due to the fatigue caused by a separate medical condition that affected the patients muscles; another withdrew from the study because of work schedule conflicts; others were excluded due to medication changes (3 patients) and one could not be included due to incomplete baseline testing.

与只接受教育(EDU)的患者相比，参加运动训练(EXE)的PH患者在6分钟步行测试距离、心肺功能测量和患者报告的健康相关生活质量方面都有显著改善。虽然ILD患者的数量仍然很少，但也观察到了类似的改善。将PH和ILD患者与健康对照志愿者进行比较，证实了这些患者每天所经历的功能损害水平。 所有组(PH组、ILD组和健康志愿者)患者总数的增加使我们能够为这项研究提供初步发现。2011年10月，我们在美国胸科医师学会年会上公布了PH组的数据。这项研究被授予阿尔弗雷德·索弗研究奖，以表彰在本次会议上提出的杰出原创性研究。最近，美国运动医学院和美国心身学会分别在2012年5月和2012年3月的年度会议上提交了其他几篇摘要。这项研究产生的第一份手稿不久将由胸科出版(已接受并正在印刷中)。还有几份手稿正在进行中，预计将在今年内出版。 虽然运动训练量和强度已经被大多数患者很好地耐受，但也有一些患者决定退出我们的研究。到目前为止，一名患者因达不到运动训练的最低次数而退出；一名患者因影响患者肌肉的单独疾病造成的疲劳而退出；另一名患者因工作日程冲突而退出研究；其他患者因药物变化而被排除在外(3名患者)，一名患者因基线测试不完整而无法纳入。