STRUCTURAL AND FUNCTIONAL WATER DYNAMICS IN RHODOPSIN ACTIVATION FROM PICOSECON

PICOSECON 视紫红质激活中的结构和功能水动力学

• 批准号: 8364358
• 负责人: MARK R CHANCE
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364358
• 关键词: Biological Models; Biomedical Research; Blood Glucose; Blood Pressure; Cell Surface Receptors; Communication; DNA Sequence Rearrangement; Drug Delivery Systems; Family; Funding; G-Protein-Coupled Receptors; Grant; Heart Rate; High Performance Computing; Human body; Marketing; Mass Spectrum Analysis; National Center for Research Resources; Principal Investigator; Process; Regulation; Research; Research Infrastructure; Resources; Rhodopsin; Role; Source; Structure; Taste Perception; Technology; United States National Institutes of Health; Vision; Water; base; computerized data processing; cost; glucose metabolism; interest; novel; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. G-protein coupled receptors (GPCR) are the largest family of cell surface receptors and are responsible for the regulation of a myriad of processes in the human body including regulation of heart rate, blood pressure and glucose metabolism as well as the senses of sight and taste. Because of their central roles in cellular communication, GPCRs have been of fundamental interest in modern pharmacological research; e.g. approximately 50% of marketed drugs target GPCRs. In this proposal we will use the resources of Anton to explore the structure and functional consequences of water rearrangements in the signaling processes of GRPCs, using rhodopsin as our model system. This will help drive experiments to detect specific water rearrangements in GPCRs using novel mass spectrometry based technologies.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 G蛋白偶联受体（GPCR）是最大的细胞表面受体家族，负责调节人体中无数过程，包括调节心率，血压和葡萄糖代谢以及视觉和味道的感觉。由于它们在细胞交流中的核心作用，GPCR在现代药理研究中具有根本兴趣。例如大约50％的销售药物靶向GPCR。在此提案中，我们将使用安东的资源来探索GRPC信号过程中水重排的结构和功能后果，并使用Rhodopsin作为我们的模型系统。这将有助于推动实验，以使用基于质谱的新技术检测GPCR中的特定水重排。