COMPUTATIONAL FLUID DYNAMICS FOR THE HEMODYNAMIC INVESTIGATION OF PEDIATRIC CAR

用于儿科车血流动力学研究的计算流体动力学

• 批准号: 8364192
• 负责人: Kerem Pekkan
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364192
• 关键词: Award; Biomedical Research; Budgets; Childhood; Coronary Artery Bypass; Data; Decision Making; Embryo; Embryonic Development; Funding; Grant; High Performance Computing; Housing; Intelligence; Investigation; Liquid substance; Methods; Morphology; National Center for Research Resources; Operative Surgical Procedures; Patients; Physiological; Principal Investigator; Process; Research; Research Infrastructure; Resolution; Resources; Source; Time; United States National Institutes of Health; cost; design; hemodynamics; operation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. we aim to continue our computational fluid dynamics (CFD) studies (i) to characterize the hemodynamic loading at the intermediate embryonic development time points as an extension of the baseline data that was recently documented by our group, ii) develop and validate our in-house high resolution immersed boundary CFD solver for embryonic subject-specific morphologies at low Re number regimes, iii) to understand and quantify the suboptimal physiological state of the failing Fontan patient group as an extension of our previous study that identified the caval waveform driven energetics of the functionally healthy patients , iv) to design interactive surgical planning methods to enable cyber generated intelligence for aiding surgical decision making process in time critical, patient specific coronary artery bypass (CABG) operations. Most importantly we plan to utilize PSC resources for our NSF-CARRER which is likely to be awarded in 2010 (Revised budget and final approval is pending NSF).

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们的目标是继续我们的计算流体动力学（CFD）研究（i）表征在中间胚胎发育时间点的血液动力学负荷，作为我们小组最近记录的基线数据的扩展，ii）开发和验证我们的内部高分辨率浸入边界CFD求解器，用于低Re数区域的胚胎受试者特定形态，iii）理解和量化失败Fontan患者组的次优生理状态，作为我们先前研究的扩展，该研究识别了功能健康患者的腔静脉波形驱动的能量学，iv）设计交互式手术规划方法，以实现网络生成的智能，用于在时间关键的患者特定冠状动脉搭桥（CABG）手术中辅助手术决策过程。最重要的是，我们计划将PSC资源用于可能于2010年授予的NSF-CARRER（修订预算和最终批准有待NSF）。