COMPUTATIONAL FLUID DYNAMICS FOR THE HEMODYNAMIC INVESTIGATION OF PEDIATRIC CAR

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们的目标是继续我们的计算流体动力学 (CFD) 研究 (i) 表征中间胚胎发育时间点的血流动力学负荷，作为我们小组最近记录的基线数据的扩展，ii) 开发和验证我们内部高分辨率浸入式边界 CFD 求解器，用于低 Re 数状态下的胚胎受试者特定形态，iii) 理解和量化失败 Fontan 患者组的次优生理状态，作为我们之前研究的延伸，该研究确定了静脉波形驱动功能健康患者的能量学，iv) 设计交互式手术规划方法，使网络生成的智能能够在时间紧迫、患者特定的冠状动脉搭桥 (CABG) 手术中帮助手术决策过程。最重要的是，我们计划将 PSC 资源用于我们的 NSF-CARRER，该项目可能会在 2010 年授予（修订后的预算和最终批准正在等待 NSF）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. we aim to continue our computational fluid dynamics (CFD) studies (i) to characterize the hemodynamic loading at the intermediate embryonic development time points as an extension of the baseline data that was recently documented by our group, ii) develop and validate our in-house high resolution immersed boundary CFD solver for embryonic subject-specific morphologies at low Re number regimes, iii) to understand and quantify the suboptimal physiological state of the failing Fontan patient group as an extension of our previous study that identified the caval waveform driven energetics of the functionally healthy patients , iv) to design interactive surgical planning methods to enable cyber generated intelligence for aiding surgical decision making process in time critical, patient specific coronary artery bypass (CABG) operations. Most importantly we plan to utilize PSC resources for our NSF-CARRER which is likely to be awarded in 2010 (Revised budget and final approval is pending NSF).