COMPUTATIONAL FLUID DYNAMICS FOR THE HEMODYNAMIC INVESTIGATION OF PEDIATRIC CAR

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们的目标是继续我们的计算流体动力学（CFD）研究（i）表征在中间胚胎发育时间点的血液动力学负荷，作为我们小组最近记录的基线数据的扩展，ii）开发和验证我们的内部高分辨率浸入边界CFD求解器，用于低Re数区域的胚胎受试者特定形态，iii）理解和量化失败Fontan患者组的次优生理状态，作为我们先前研究的扩展，该研究识别了功能健康患者的腔静脉波形驱动的能量学，iv）设计交互式手术规划方法，以实现网络生成的智能，用于在时间关键的患者特定冠状动脉搭桥（CABG）手术中辅助手术决策过程。最重要的是，我们计划将PSC资源用于可能于2010年授予的NSF-CARRER（修订预算和最终批准有待NSF）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. we aim to continue our computational fluid dynamics (CFD) studies (i) to characterize the hemodynamic loading at the intermediate embryonic development time points as an extension of the baseline data that was recently documented by our group, ii) develop and validate our in-house high resolution immersed boundary CFD solver for embryonic subject-specific morphologies at low Re number regimes, iii) to understand and quantify the suboptimal physiological state of the failing Fontan patient group as an extension of our previous study that identified the caval waveform driven energetics of the functionally healthy patients , iv) to design interactive surgical planning methods to enable cyber generated intelligence for aiding surgical decision making process in time critical, patient specific coronary artery bypass (CABG) operations. Most importantly we plan to utilize PSC resources for our NSF-CARRER which is likely to be awarded in 2010 (Revised budget and final approval is pending NSF).