SPECTROSCOPIC SCANNER FOR COMPREHENSIVE ASSESSMENT OF SURGICAL EXCISION MARGINS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本计画主要是制作一台能全面评估手术切缘之定量光谱扫描仪，并进行初步验证。我们将设计和构建一种定量光谱成像仪器，用于评估离体组织生化和形态信息。将通过机械扫描光学光谱探针（类似于在各种LBRC临床应用中广泛使用的FastEEM探针）来实现广域定量光谱数据采集。仪器性能将在实验室环境中得到充分表征和优化。将在临床上部署优化的临床仪器，用于评估乳腺切除边缘的可行性研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project is to fabricate and initial validatation of a quantitative spectroscopic scanner for comprehensive assessment of surgical margins. We will design and construct a quantitative spectroscopic imaging instrument for assessing ex vivo tissue biochemical and morphological information. The wide area quantitative spectroscopic data acquisition will be achieved by mechanically scanning an optical spectroscopic probe similar to the FastEEM probe extensively used in various LBRC clinical applications. Instrument performance will be fully characterized and optimized in the laboratory setting. An optimized clinical instrument will be deployed clinically for feasibility studies in assessment of breast excision margins.