Identification of Athletes at Risk for Traumatic Brain Injuries

识别有脑外伤风险的运动员

基本信息

  • 批准号:
    7658688
  • 负责人:
  • 金额:
    $ 33.08万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-09-30 至 2012-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Multiple traumas to the brain are the most common type of catastrophic injury and a leading cause of death in athletes. Multiple brain injuries may occur as the long-term disabilities resulting from a single mild traumatic brain injury (MTBI) are often overlooked and the most obvious clinical symptoms appear to resolve rapidly. Most previous research has: a) failed to provide pure pre-injury status of MBTI subjects which may lead to misdiagnosis of the persistent or new neurological and behavioral deficits following a single brain injury; b) focused primarily on transient deficits after single MTBI, and failed to examine long-term deficits and symptoms of multiple MTBI; c) focused primarily on pathophysiology, neurocognitive or behavioral sequelae of MTBI in isolation; and d) failed to identify and predict athletes at risk for traumatic brain injury. We will build on our previous work and plan to identify and examine both transient and long-term behavioral, sensory-motor, neuropsychological, and neural mechanisms that are interactively affected by MTBI. We aim to provide direct evidence that there are long-lasting residual disabilities in subjects suffering from MTBI. We hypothesize that the rate of brain injury symptom resolution predicts the probability of multiple brain injuries in athletes at risk. Our specific aims are: 1) to identify neural mechanisms associated with transient and long-term residual postural abnormalities as a result of single and multiple MTBI; 2) to identify abnormal mechanisms associated with neurocognitive deficits, including those specifically involved in postural control in subjects suffering from MTBI; 3) to examine destabilizing neural mechanisms in MTBI subjects via manipulations of visual field motion; and, 4) to develop and test unsupervised pattern recognition algorithms for predicting athletes at risk for a single and multiple MTBI. The behavioral, neurocognitive and neural dysfunctions will be tested in student-athletes at risk prior to and after a single and multiple brain injuries using a longitudinal design. A set of tools for assessment of mild traumatic brain injury will be developed based on computer graphics and virtual reality (VR) technologies incorporated with modern human movement analysis and brain imaging (EEG and MRI) techniques. Preliminary research in our laboratory has provided strong evidence for the feasibility of the proposed approach to examine the functional changes in the brain, cognition and balance and to identify athletes at risk for a single and multiple MTBI. Brain damage has been referred to as the "silent epidemic," primarily due to its high level of incidence and the lack of acknowledgement when compared to many other large-scale health issues. In sport and recreational activities alone, there are approximately 300,000 concussions in the United States annually, carrying a $9 to $10-billion price tag for acute care and rehabilitation. In this context, single and multiple concussions are relevant to the study of brain injury in general and in traumatic brain injury in those at risk, such as athletes, as a prototypical example of both short and long-term brain disorders. This project seeks to develop new comprehensive concussion assessment procedures aimed at predicting subjects at risk for concussion and ultimately preventing multiple traumatic brain injuries.
描述(由申请人提供):脑部多发性创伤是最常见的灾难性损伤类型,也是运动员死亡的主要原因。可能会发生多发性脑损伤,因为单次轻度创伤性脑损伤 (MTBI) 导致的长期残疾常常被忽视,而且最明显的临床症状似乎会迅速消退。大多数先前的研究:a)未能提供 MBTI 受试者的纯粹损伤前状态,这可能导致对单次脑损伤后持续或新的神经和行为缺陷的误诊; b) 主要关注单次 MTBI 后的短暂缺陷,未能检查多次 MTBI 的长期缺陷和症状; c) 主要关注 MTBI 的病理生理学、神经认知或行为后遗症; d) 未能识别和预测有脑外伤风险的运动员。我们将在之前的工作基础上,计划识别和检查受 MTBI 交互影响的短暂和长期行为、感觉运动、神经心理学和神经机制。我们的目标是提供直接证据,证明 MTBI 受试者存在长期残余残疾。我们假设脑损伤症状的缓解率可以预测处于危险中的运动员发生多发性脑损伤的可能性。我们的具体目标是:1)确定与单次和多次 MTBI 导致的短暂和长期残留姿势异常相关的神经机制; 2) 识别与神经认知缺陷相关的异常机制,包括那些特别涉及 MTBI 受试者姿势控制的机制; 3) 通过操纵视野运动来检查 MTBI 受试者的不稳定神经机制; 4) 开发和测试无监督模式识别算法,用于预测运动员面临单一和多个 MTBI 的风险。将使用纵向设计在单次和多次脑损伤前后对处于危险中的学生运动员进行行为、神经认知和神经功能障碍测试。将基于计算机图形学和虚拟现实(VR)技术,结合现代人体运动分析和脑成像(EEG和MRI)技术,开发一套用于评估轻度创伤性脑损伤的工具。我们实验室的初步研究为所提出的方法的可行性提供了强有力的证据,该方法可检查大脑、认知和平衡的功能变化,并识别有单一和多重 MTBI 风险的运动员。脑损伤被称为“无声的流行病”,主要是因为与许多其他大规模健康问题相比,其发病率较高且缺乏认识。仅在体育和娱乐活动中,美国每年大约发生 30 万起脑震荡,急症护理和康复费用高达 9 至 100 亿美元。在这种情况下,单次和多次脑震荡与一般脑损伤和高危人群(例如运动员)的创伤性脑损伤的研究相关,作为短期和长期脑部疾病的典型例子。该项目旨在开发新的全面脑震荡评估程序,旨在预测有脑震荡风险的受试者,并最终预防多发性脑损伤。

项目成果

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Semyon Slobounov其他文献

Semyon Slobounov的其他文献

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{{ truncateString('Semyon Slobounov', 18)}}的其他基金

Identification of Athletes at Risk for Traumatic Brain Injuries
识别有脑外伤风险的运动员
  • 批准号:
    7916883
  • 财政年份:
    2007
  • 资助金额:
    $ 33.08万
  • 项目类别:
Identification of Athletes at Risk for Traumatic Brain Injuries
识别有脑外伤风险的运动员
  • 批准号:
    7372156
  • 财政年份:
    2007
  • 资助金额:
    $ 33.08万
  • 项目类别:
Identification of Athletes at Risk for Traumatic Brain Injuries
识别有脑外伤风险的运动员
  • 批准号:
    7503339
  • 财政年份:
    2007
  • 资助金额:
    $ 33.08万
  • 项目类别:
Identification of Athletes at Risk for Traumatic Brain Injuries
识别有脑外伤风险的运动员
  • 批准号:
    8118545
  • 财政年份:
    2007
  • 资助金额:
    $ 33.08万
  • 项目类别:
Identification of Athletes at Risk for Traumatic Brain Injuries
识别有脑外伤风险的运动员
  • 批准号:
    8069094
  • 财政年份:
    2007
  • 资助金额:
    $ 33.08万
  • 项目类别:
Identification of Athletes at Risk for Traumatic Brain Injuries
识别有脑外伤风险的运动员
  • 批准号:
    7908717
  • 财政年份:
    2007
  • 资助金额:
    $ 33.08万
  • 项目类别:

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