Superhydrophobic Implantable Surface and 3D Printing Technology for Targeted Dental Photodynamic Therapy

用于靶向牙科光动力治疗的超疏水植入表面和 3D 打印技术

• 批准号: 9339656
• 负责人: ALEXANDER GREER
• 金额: $ 7.62万
• 依托单位: SINGLETO2 THERAPEUTICS, LLC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9339656
• 关键词: 3D Print; Air; Anaerobic Bacteria; Antibiotics; Bacteria; Bacteroides forsythus; Cells; Chemistry; Dental; Dental Care; Dentists; Development; Device Designs; Devices; Diabetes Mellitus; Disinfection; Doxycycline; Drug Sensitization; Engineering; Fiber; Fluorine; Fusobacterium nucleatum; Gases; Health; Human; Hydroxyapatites; Hypoxia; Implant; In Situ; In Vitro; Infection; Inflammation; Legal patent; Ligature; Light; Methods; Microbial Biofilms; Minocycline; Modeling; Molecular; Mus; Operative Surgical Procedures; Oral; Oral cavity; Oral health; Oxygen; PUVA Photochemotherapy; Pain; Periodontal Diseases; Periodontal Infection; Periodontal Pocket; Phase; Photosensitization; Plague; Population; Porphyromonas gingivalis; Positioning Attribute; Printing; Pulp Canals; Recurrence; Saliva; Silicon Dioxide; Singlet Oxygen; Site; Source; Sterilization; Surface; System; Technology; Temoporfin; Therapeutic; Tissues; Tobacco use; Tooth structure; Treatment Cost; Visit; Work; bacterial resistance; chlorin; combat; cytotoxic; design; healing; impression; improved; innovation; killings; oral biofilm; oral care; oxidation; particle; peri-implantitis; periopathogen; photobiomodulation; photoprotection; programs; prototype; residence; scaling and root planing; tool; treatment strategy

Project Summary/Abstract Eradication of bacteria that are located in periodontal pockets is a daunting challenge to dentists and oral care professionals. Doxycycline or minocycline with scaling and root planing (S&RP) have been the mainstays, but the field urgently needs further advances in perio bacteria eradication. A high precision, photochemical implement that could be used simultaneously with S&RP would reduce or eliminate these problems. The development of a device for the precise delivery of reactive singlet oxygen would be a major breakthrough for periodontal photodynamic therapy (PDT). The device tip is superhydrophobic and capable of delivering singlet oxygen (a cytotoxic excited state of molecular oxygen) in a controllable fashion. The device offers precise delivery of singlet oxygen to hypoxic bacterial pockets, creating a highly-localized killing zone. We have developed an innovative superhydrophobic-tipped device, which can be inserted at the infection site. The tip discharges singlet oxygen at the infection site and nowhere else in the mouth. The objective of this proposal is to design device tips and validate their use in vitro with hypoxic mixed cultures and saliva biofilms.

项目总结/摘要 根除位于牙周袋中的细菌是一项艰巨的挑战， 牙医和口腔护理专业人员。多西环素或米诺环素伴洁治和根治 规划（S&RP）一直是主流，但该领域迫切需要进一步的进展， 牙周细菌根除。一种高精度的光化学工具， 与S&RP同时进行将减少或消除这些问题。 开发一种精确输送活性单线态氧的装置， 牙周光动力疗法（PDT）的重大突破。器械头端 超疏水性的并且能够递送单线态氧（细胞毒性激发态， 分子氧）。该设备提供了单重态的精确输送， 将氧气输送到缺氧的细菌口袋，形成高度局部化的杀伤区。 我们开发了一种创新的超疏水尖端装置， 在感染部位。尖端在感染部位释放单线态氧， 还有在嘴里。本提案的目的是设计器械尖端并验证其 在体外与低氧混合培养物和唾液生物膜一起使用。