Impact of insecticide resistance on the behavior and fitness of malaria vectors

杀虫剂耐药性对疟疾病媒行为和适应性的影响

基本信息

项目摘要

 DESCRIPTION (provided by applicant): Malaria is still a major public health problem in Africa despite the continuous deployment of interventions within the region. Vector control is one of the important strategies being used in the fight against malaria. These efforts include large-scale distribution of long-lasting impregnated nets (LLINs) and indoor residual spraying (IRS). Although these control measures have been successful in reducing malaria incidence since its initial scale-up in early 2000s, within the last few years there has been resurgence of malaria incidence in most parts of Africa, including Kenya. One of the factors that has been implicated in this malaria resurgence is insecticide resistance. The increased use of insecticide-based malaria vector control tools in the past decade have placed greater selection pressure on malaria vector populations resulting in higher rates of the incidence of insecticide resistance tha is likely to impact on the effectiveness of vector control. Despite increased control efforts, ther is evidence of limited impact and a resurgence of clinical malaria in parts of sub-Saharan Africa including Kenya. There is also evidence of shifts in vector behavior and species composition. There is pressing need to develop viable insecticide resistance management strategies. These strategies are predicated upon better understanding of the effects of insecticide resistance on vector behavior and fitness. The overall objective of this application is to determine the effect o insecticide resistance on the behavior and fitness of the main malaria vectors of Sub-Saharan Africa, Anopheles gambiae, An. arabiensis and An. funestus, and their impact on malaria transmission in Kenya. The long-term objective is to determine the changes in the ecology of malaria vector species during the period of most intensive malaria intervention programs in Africa. I have designed 3 specific aims to achieve this objectives. This will be the first study tht will analyze and quantify behavioral resistance in the three main major malaria vector species in Africa using different insecticides. In Aim 1, we will determine how evolution of insecticide resistance in vector mosquitoes affects their feeding and resting behavior. Insecticide resistance could affect mosquitoes to adapt behaviorally and therefore change from feeding indoors to outdoors and resting outdoors because of pressure from the use of LLINs and IRS, which are indoor based. These behavioral changes will likely affect vector potential to transmit malaria. Aim 2 will test how insecticide resistance in vectors affects their fitness for development, survivorship, reproductive potential and infectiousness. The actual cost of the fitness needs to be studied to understand how the development of resistance affects the vectorial capacity of these vectors. Aim 3 is to predict and validate the consequences of insecticide resistance on malaria transmission which is important in helping policy makers to better parameterize models that guide malaria interventions. Results from this study will help understand the mechanisms for malaria resurgence in Africa, help to come out with better strategies to manage insecticide resistance in malaria vectors and help in coming up with models for malaria vector control.
 描述(由申请人提供):尽管在该地区不断部署干预措施,但疟疾仍然是非洲的一个主要公共卫生问题。病媒控制是抗击疟疾的重要策略之一。这些努力包括大规模分发长效浸渍蚊帐(LLIN)和室内滞留喷洒(IRS)。尽管这些控制措施自 2000 年代初首次扩大规模以来已成功减少了疟疾发病率,但在过去几年中,包括肯尼亚在内的非洲大部分地区疟疾发病率再次出现。导致疟疾死灰复燃的因素之一是杀虫剂耐药性。过去十年中,基于杀虫剂的疟疾病媒控制工具的使用增加,给疟疾病媒种群带来了更大的选择压力,导致杀虫剂耐药性的发生率更高,这可能会影响病媒控制的有效性。尽管加大了控制力度,但有证据表明,在包括肯尼亚在内的撒哈拉以南非洲部分地区,临床疟疾的影响有限,而且临床疟疾死灰复燃。还有证据表明媒介行为和物种组成发生了变化。迫切需要制定可行的杀虫剂抗性管理策略。这些策略的基础是更好地了解杀虫剂抗性对病媒行为和适应性的影响。本应用的总体目标是确定杀虫剂耐药性对撒哈拉以南非洲主要疟疾病媒冈比亚按蚊 (Anopheles gambiae) 的行为和适应性的影响。阿拉伯和安。 funestus 及其对肯尼亚疟疾传播的影响。长期目标是确定在非洲最密集的疟疾干预计划期间疟疾病媒物种的生态变化。为了实现这一目标,我设计了 3 个具体目标。这将是第一项分析和量化非洲三种主要疟疾病媒物种使用不同杀虫剂的行为抗性的研究。在目标 1 中,我们将确定媒介蚊子的杀虫剂抗性进化如何影响其摄食和休息行为。杀虫剂抗药性可能会影响蚊子的行为适应,因此由于使用基于室内的 LLIN 和 IRS 的压力,它们从室内进食改为室外进食并在室外休息。这些行为变化可能会影响传播疟疾的媒介潜力。目标 2 将测试媒介的杀虫剂抗性如何影响其发育适应性、生存能力、繁殖潜力和传染性。需要研究适应度的实际成本,以了解阻力的发展如何影响这些向量的向量容量。目标 3 是预测和验证杀虫剂耐药性对疟疾传播的影响,这对于帮助政策制定者更好地参数化指导疟疾干预措施的模型非常重要。这项研究的结果将有助于了解非洲疟疾死灰复燃的机制,有助于制定更好的策略来管理疟疾病媒的杀虫剂耐药性,并有助于提出疟疾病媒控制模型。

项目成果

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YAW ASARE AFRANE其他文献

YAW ASARE AFRANE的其他文献

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{{ truncateString('YAW ASARE AFRANE', 18)}}的其他基金

Regional Centre for Vector Borne Diseases in West Africa (RCVBD)
西非媒介传播疾病区域中心 (RCVBD)
  • 批准号:
    10377584
  • 财政年份:
    2021
  • 资助金额:
    $ 13.33万
  • 项目类别:
Regional Centre for Vector Borne Diseases in West Africa (RCVBD)
西非媒介传播疾病区域中心 (RCVBD)
  • 批准号:
    10579219
  • 财政年份:
    2021
  • 资助金额:
    $ 13.33万
  • 项目类别:
Regional Centre for Vector Borne Diseases in West Africa (RCVBD)
西非媒介传播疾病区域中心 (RCVBD)
  • 批准号:
    10239374
  • 财政年份:
    2021
  • 资助金额:
    $ 13.33万
  • 项目类别:
Impact of insecticide resistance on the behavior and fitness of malaria vectors
杀虫剂耐药性对疟疾病媒行为和适应性的影响
  • 批准号:
    9882939
  • 财政年份:
    2016
  • 资助金额:
    $ 13.33万
  • 项目类别:
Ecology and genetics of insecticide resistance in African malaria vectors
非洲疟疾媒介的杀虫剂抗药性的生态学和遗传学
  • 批准号:
    10674140
  • 财政年份:
    2016
  • 资助金额:
    $ 13.33万
  • 项目类别:
Impact of insecticide resistance on the behavior and fitness of malaria vectors
杀虫剂耐药性对疟疾病媒行为和适应性的影响
  • 批准号:
    9072538
  • 财政年份:
    2016
  • 资助金额:
    $ 13.33万
  • 项目类别:
EPIDEMIOLOGY OF CLINICAL MALARIA IN WESTERN KENYA HIGHLANDS
肯尼亚西部高地临床疟疾的流行病学
  • 批准号:
    8442189
  • 财政年份:
    2011
  • 资助金额:
    $ 13.33万
  • 项目类别:
EPIDEMIOLOGY OF CLINICAL MALARIA IN WESTERN KENYA HIGHLANDS
肯尼亚西部高地临床疟疾的流行病学
  • 批准号:
    8223689
  • 财政年份:
    2011
  • 资助金额:
    $ 13.33万
  • 项目类别:
EPIDEMIOLOGY OF CLINICAL MALARIA IN WESTERN KENYA HIGHLANDS
肯尼亚西部高地临床疟疾的流行病学
  • 批准号:
    8649002
  • 财政年份:
    2011
  • 资助金额:
    $ 13.33万
  • 项目类别:
EPIDEMIOLOGY OF CLINICAL MALARIA IN WESTERN KENYA HIGHLANDS
肯尼亚西部高地临床疟疾的流行病学
  • 批准号:
    7936540
  • 财政年份:
    2011
  • 资助金额:
    $ 13.33万
  • 项目类别:

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