Clinical-In Vivo Functional Onco-Imaging (IVFOI)

CORE 006-临床-项目摘要/摘要-体内功能肿瘤成像(IVFOI) 体内功能肿瘤成像(IVFOI)共享资源的目的是增强和支持基础 和临床癌症研究人员，为他们提供必要的专业知识、成像仪器和 图像分析技术。目前可用的系统包括三台MRI扫描仪(3T-Human、4T-Human 和动物，以及7T动物)和几种用于小动物的尖端多模式成像系统 成像：a)联合MRI-漫反射光学断层扫描(DOT)系统，b)联合MRI-SPECT(单一 光子发射计算机层析成像)系统，以及c)混合X射线微CT光学层析成像系统。 4T MRI扫描仪为开发新的成像方法提供了一个开放的架构，以及 集成第二种模式，例如DOT，以形成组合系统。除了光学成像，我们还有 建造了世界上第一个用于小动物成像的磁共振兼容SPECT系统。除此之外，我们还有 开发了一种集成微型CT的三维荧光生物发光层析成像系统。这些多- 在这一点上，形态成像系统可用于一般用途。在这个小动物形象之外 仪器，我们一直致力于乳腺癌成像的几个新的多模式系统，MR- 光学和MR-核成像，我们计划将它们提供给癌症癌症研究中心的成员 接下来的几年。这些系统将支持CFCCC成员在设计创新成像方面的各种需求 在他们的研究中，提供补充的解剖学和功能信息。另外， 我们的共享资源还支持转化性临床研究，具有精确的方案执行和高 标准的质量控制。例如，我们一直支持收集900多个乳房核磁共振 使用统一协议的研究，因此收集了一个大型数据库。在下一个周期中，我们将 继续支持此类临床研究，并支持使用多- 医疗设备成像系统在我们的产品组合中，例如评估组合的诊断性能 核磁共振-光学和核磁共振-乳腺癌的核成像系统。 总体而言，IVFOI共享资源为CFCCC成员提供了随时访问最先进技术的途径 技术，实验和成像方案设计咨询，以及图像采集和数据 分析，以及各个项目之间的协调。通过图像和分析的共享 协议，我们可以集成从不同项目获得的各种信息，以促进未来的合作 CFCCC成员之间的合作，并将基础科学家和临床研究人员聚集在一起设计和 开展临床翻译研究。

Core 006 - Clinical - Project Summary/Abstract - In Vivo Functional Onco-Imaging (IVFOI) The aim of the In-Vivo Functional Onco-Imaging (IVFOI) Shared Resource is to enhance and support basic and clinical cancer researchers by providing them with the necessary expertise, imaging instrumentation, and image analysis techniques. The current available systems include three MRI scanners (3T- human, 4T- human and animal, and 7T- animal) and several cutting-edge multi-modality imaging systems for small animal imaging: a) combined MRI- Diffuse Optical Tomography (DOT) system, b) combined MRI-SPECT (Single Photon Emission Computed Tomography) system, and c) hybrid X-ray microCT-Optical Tomography system. The 4T MRI scanner provides an open architecture for development of new imaging methods, as well as for integration of a second modality such as DOT to form a combined system. Besides optical imaging, we have built world's first MR compatible SPECT system for small animal imaging. In addition to this we have developed a 3-D fluorescence & bioluminescence tomography system integrated with a micro CT. These multi- modality imaging systems are available for general use at this point. Beyond this small animal imaging instrumentation, we have been working on several new multi-modality systems for breast cancer imaging, MR- Optical and MR-Nuclear Imaging, and we are planning to make them available for Cancer Canter members in the next years. These systems will support various needs of CFCCC members in designing innovative imaging components into their studies, providing complementary anatomical and functional information. Additionally, our shared resource also supports translational clinical studies, with a precise protocol execution and a high standard quality control. For example, we have been supporting the collection of more than 900 breast MRI studies with unified protocols, and as such a large database has been collected. In the next cycle we will continue to support such clinical studies, and also to support translational clinical research using the multi- modality imaging systems in our portfolio, such as to evaluate the diagnostic performance of the combined MRI-Optical and MR-Nuclear imaging systems for breast cancer. Overall, the IVFOI Shared Resource provides CFCCC Members with ready access to state-of-the-art technologies, consultation for design of experiments and imaging protocols, and image acquisition and data analysis, as well as coordination among individual projects. Through the sharing of imaging and analysis protocols, we can integrate various information obtained from different projects to facilitate future collaborations between CFCCC members and to bring together basic scientists and clinical researchers to design and conduct clinical translational studies.