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Ohio State University Neuroscience Center Core

俄亥俄州立大学神经科学中心核心

基本信息

批准号：
9433157
负责人：
Anthony Brown
金额：
$ 45.84万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9433157
关键词：
Address Adoption Anxiety Area Award Basic Science Behavior Behavioral Brain Brain Injuries Brain Neoplasms Budgets Cancer Grant Supplements (P30)Cells Circadian Rhythms Clinical Collaborations Color Communication Communities Consult Consultations Contusions Core Facility Cultured Cells Data Analyses Electrophysiology (science)Embryo Ensure Environment Equilibrium Equipment Expenditure Experimental Designs Fluorescence Fluorescence Microscopy Fluorescence Resonance Energy Transfer Fostering Funding Group Meetings Health Services Accessibility Hospitals Human Resources Image Image Analysis Individual Injury Institutes Investments Joints Laboratories Learning Lesion Locomotor Recovery Memory Microinjections Microscope Modeling Monitor Mus National Institute of Neurological Disorders and Stroke Nervous System Trauma Neurodegenerative Disorders Neuroglia Neuromuscular Diseases Neurons Neurosciences Neurosciences Research Ohio Peer Review Peripheral nerve injury Phenotype Policies Procedures Productivity Progress Reports Protocols documentation Publications Qualifying Rattus Research Research Infrastructure Research Institute Research Personnel Research Project Grants Research Support Rodent Rodent Model Running Scanning Schedule Sensory Services Slice Speed Spinal Standardization Surgical Injuries Technical Expertise Technology Testing Time Tissues Toxin Training Translational Research Traumatic Brain Injury United States National Institutes of Health Universities Vertebral column Work Zebrafish behavior test behavioral study catalyst cost depressive symptoms equipment training experience experimental study flexibility fluorescence imaging high standard image processing interdisciplinary approach meetings nervous system disorder new technology novel strategies operation optogenetics photoactivation response skills spinal cord and brain injury

项目摘要

The Ohio State University (OSU) Neuroscience Center Core, now in its 12th year of NINDS support, provides specialized expertise and services that support research into the causes and treatments of neurological disorders. The Center serves a total of more than 40 neuroscientists (20 NINDS-funded) from multiple departments, centers, and institutes, and has become a catalyst for neuroscience research and collaboration across campus. Areas of strength include basic and translational research on neurodegenerative and neuromuscular diseases, brain tumors and neurotrauma. The Center leverages substantial institutional investment and federal support in research infrastructure and neuroscience at OSU. This includes the recently formed Brain and Spine Hospital and the Neuroscience Research Institute, a multi-million dollar effort that aligns the activities of about 175 basic and clinical neuroscientists across campus. The Center comprises one Administrative Core and four Scientific Cores, all of which are established, functional and successful. The Scientific Cores provide access to services, equipment and expertise not otherwise available to individual PIs, enhancing their ability to execute the aims of their funded projects and facilitating their adoption of new approaches and technologies. This centralization of expertise and equipment in the Scientific Cores increases the efficiency and quality of NINDS-funded research at OSU by minimizing duplication of effort and equipment, and ensuring the uniform application of best practices. The Cores are directed by investigators with deep and proven expertise in the Core services. Core A (Administrative) sets policies, oversees the Core operations and budget, and facilitates communication of Core services to neuroscientists on campus. The Core arranges meetings of the Neuroscience User Group in order to promote core services, identify new needs, and promote cross-core collaborations. Core B (Injury) provides equipment, training and technical expertise, including standardized and well-characterized injury protocols, to support research on spinal cord and brain injury models in rodents. Core C (Behavior) provides access to the equipment and skilled technical expertise necessary to perform comprehensive behavioral phenotyping of rodent models, as well as expert training and consultation on the execution of behavioral experiments. Core D (Electrophysiology) provides specialized equipment, training and technical expertise necessary to monitor and record the electrical activity of neurons and glia. Core E (Imaging) provides access to confocal microscopes including expert training, consultation and assistance with fluorescence imaging of living and fixed cells, tissues and embryos. Collectively these Cores will support 23 NINDS-funded projects (including 12 qualifying R01 projects) totaling $7.5 million dollars in annual funding, plus 14 other NIH-funded neuroscience projects totaling $3.9 million in annual funding, enhancing the research environment for these projects and fostering a cooperative and interactive research environment in which multi-disciplinary approaches and joint research efforts are stimulated.

俄亥俄州立大学（OSU）神经科学中心核心，现在是NINDS支持的第12个年头，提供