The Role of Place and Grid Cells in Human Spatial Navigation and Memory

位置和网格细胞在人类空间导航和记忆中的作用

• 批准号: 9284520
• 负责人: Joshua Jacobs
• 金额: $ 46.61万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-17 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9284520
• 关键词: 3-Dimensional; Animal Model; Animals; Appearance; Behavior; Brain; Cells; Code; Cognition; Collaborations; Complex; Computers; Data; Data Aggregation; Data Set; Databases; Environment; Epilepsy; Floor; Goals; Handedness; Hippocampus (Brain); Human; Implanted Electrodes; Individual; Knowledge; Learning; Left; Lesion; Life; Location; Maps; Medial; Memory; Modeling; Nature; Neurons; Neurosciences; Patients; Pattern; Persons; Phase; Physiology; Play; Probability; Property; Research; Rodent; Role; Scheme; Site; System; Temporal Lobe; Testing; Theta Rhythm; Travel; Uncertainty; Work; cell cortex; data sharing; entorhinal cortex; experimental study; imaging study; improved; insight; memory process; neurotransmission; public health relevance; relating to nervous system; research study; spatial memory; success; support network; theories; virtual; way finding

 DESCRIPTION (provided by applicant): Spatial navigation and learning is a critical part of life for humans and animals. Our experiments examine how spatial knowledge is represented by individual cells in the human medial temporal lobe. We test the hypothesis that human navigation is supported by networks of place and grid cells, each of which help encode a person's location in a spatial environment by activating at individual locations and groups of locations, respectively. We probe the functional roles of grid and place cells in human spatial navigation and memory by directly recording the activity of these cells from epilepsy patients performing a computer virtual-navigation task. Specific Aims one and four of our work test whether theories of grid and place cells from animal models are relevant for humans. First, we probe the properties of these cells, and their interactions with neuronal oscillations, by conducting a new experiment that is optimized to reveal the human neural representation of space. We will test whether human place and grid cells are most prominent to the right hemisphere, consistent with the classic finding that human spatial processing is right lateralized. Our second and third Specific Aims probe grid and place cells in more complex navigation tasks. Here we test for new neural coding patterns beyond those found in animals. We will test whether place and grid cells are involved in transferring spatial knowledge between related environments and in representing spatial information in outside of active navigation. Our research studies are likely to yield insights into the neural signals that allow humans to navigate and they also have implications for revealing a broader understanding of human memory.

 空间导航和学习是人类和动物生活的重要组成部分。我们的实验研究空间知识是如何由人类内侧颞叶的单个细胞表示的。我们测试的假设，人类导航是由网络的地方和网格细胞，其中每一个帮助编码一个人的位置在空间环境中激活在个别位置和位置组，分别支持。我们通过直接记录癫痫患者执行计算机虚拟导航任务的网格和位置细胞的活动，探索这些细胞在人类空间导航和记忆中的功能作用。具体目标1和4，我们的工作测试是否网格和位置细胞的理论，从动物模型是相关的人类。首先，我们通过进行一项新的实验来探索这些细胞的特性，以及它们与神经元振荡的相互作用，该实验被优化以揭示人类神经对空间的表征。我们将测试人类的位置和网格细胞是否在右半球最突出，这与人类空间处理是右侧化的经典发现一致。 我们的第二个和第三个特定目标探测网格，并将细胞放置在更复杂的导航任务中。在这里，我们测试新的神经编码模式，超越了在动物中发现的模式。我们将测试位置和网格单元是否参与相关环境之间的空间知识转移，并在主动导航之外表示空间信息。我们的研究很可能会深入了解让人类导航的神经信号 它们还对揭示对人类记忆的更广泛理解具有影响。