Development of Novel Ultrasensitive Devices for the Measurement of VOCs

开发用于测量 VOC 的新型超灵敏设备

• 批准号: 9260446
• 负责人: Michael H Nantz
• 金额: $ 17.77万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9260446
• 关键词: 1,3-Butadiene; Acrolein; Acute; Adsorption; Air; Benzene; Biomedical Research; Butadiene; Chemicals; Chronic; Complex; Coupled; Custom; Detection; Development; Devices; Disease; Ecology; Electrodes; Engineering; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Exposure to; Face; Gas Chromatography; Gases; Goals; Gold; Health; High Pressure Liquid Chromatography; Human; Insulin Resistance; Ions; Liquid substance; Mass Spectrum Analysis; Measurement; Measures; Methods; Modification; Normal Range; Oxidants; Pattern; Process; Research; Research Project Grants; Security; Signal Transduction; Silicon; Site; Sulfhydryl Compounds; Superfund; Surface; System; Techniques; Technology; Temperature; Tube; Vinyl Chloride; Work; adduct; air sampling; base; carbonyl compound; cost; design; functional group; glycolaldehyde; improved; mass spectrometer; metal oxide; microsensor; miniaturize; nanoparticle; new technology; novel; sensor; simulation; superfund site; vascular inflammation; volatile organic compound

Hazardous volatile organic compounds (VOCs) in environmental air have both acute and chronic effects on human health. Gas chromatography coupled with a mass spectrometer (GC- MS) is the most common technology used for analysis of airborne VOCs. However, GC-MS is not effective for on-site measurement of trace VOCs at Superfund sites. The overall goal of this environmental science research project is to develop novel technologies for quantitative analysis of trace VOCs in both the lab and for on-site measurement of toxic, airborne VOCs. We will focus on measurements of acrolein, vinyl chloride, benzene and 1,3-butadiene. The approach is to investigate chemoselective microreactors for capture of Superfund VOCs. Microreactors provide superior advantages of miniaturized device size, very low cost, and fast detection over current sorbent-based tube preconcentrators. We also will develop thiol-modified gold nanoparticle gas sensor arrays for on-site detection of these VOCs. Functionalized thiols will be synthesized to detect target VOCs at a concentration range from sub-ppb to a few ppm. The thiols proposed for modification of gold nanoparticles will have functional groups and structural motifs to specifically promote interaction with and recognition of target VOCs, thus significantly increasing sensing selectivity and sensitivity. The sensors will work at ambient temperature. This research project will lead to transformational technologies for quantitative analysis of trace VOCs. The research is directly related to the overall goals of the Center for investigating the effects of exposure to VOCs on inducing/exacerbating cardiometabolic disease. The project will also have significant broader impacts on monitoring environmental air and on promoting homeland security.

环境空气中的有害挥发性有机化合物（VOC）具有急性和 对人体健康的慢性影响。气相色谱-质谱联用仪（GC-2000） MS）是用于分析空气中VOC的最常用技术。然而，GC-MS 在超级基金场地现场测量痕量挥发性有机化合物无效。总的目标是 环境科学研究项目是开发新的技术，定量 在实验室和现场测量有毒的空气中挥发性有机化合物的痕量挥发性有机化合物分析。 我们将着重于丙烯醛、氯乙烯、苯和1，3-丁二烯的测量。的 方法是研究化学选择性微反应器用于捕获Superfund VOCs。 微反应器提供了装置尺寸小型化、成本非常低和快速的上级优点。 检测超过当前基于吸附剂的管式预浓缩器。我们还将开发巯基修饰的 金纳米颗粒气体传感器阵列用于现场检测这些挥发性有机化合物。官能化硫醇 将被合成以检测浓度范围从亚ppb到几ppm的目标VOC。 提出用于金纳米颗粒改性的硫醇将具有官能团， 结构基序特异性地促进与目标VOC的相互作用和识别，因此 显著增加了传感选择性和灵敏度。传感器将在环境温度下工作 温度该研究项目将导致量化的转型技术 痕量VOC分析该研究直接关系到中心的总体目标， 研究暴露于VOC对诱导/加重心脏代谢的影响 疾病该项目还将对监测环境空气产生更广泛的重大影响 以及促进国土安全。