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Epigenetics of social bonding in prairie voles

草原田鼠社会联系的表观遗传学

基本信息

批准号：
9489311
负责人：
MOHAMED KABBAJ
金额：
$ 38万
依托单位：
FLORIDA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-26 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9489311
关键词：
AVPR1A gene Acetylation Aggressive behavior American Animal Model Animals Antisocial Personality Disorder Appearance Autistic Disorder Behavior Brain Brain region Breeding Child CpG Islands DNA Methylation DRD1 gene Data Development Disease Dopamine D1 Receptor Enzymes Epigenetic Process Female Gene Targeting Genes Histone Acetylation Histone Deacetylase Histone Deacetylase Inhibitor Histone H3 Histones Human Injections Lead Maintenance Mediating Mental disorders Methylation Microtus Modification Molecular Neurobiology Nucleus Accumbens Oxytocin Receptor Pair Bond Partner in relationship Prevalence Promoter Regions Psychopathology Publishing Receptor Gene Reporting Role Schizophrenia Seasons Social Development Sodium Butyrate Structure Study models Symptoms Testing Time Trichostatin A Vasopressin Receptor Work anti social autism spectrum disorder demethylation epigenetic regulation genome-wide histone methylation histone modification mRNA Expression male men neuroadaptation novel prairie vole preference promoter protein expression receptor sex social attachment

项目摘要

PROJECT ABSTRACT Social attachments are a vital part of healthy human behavior and an inability to form such attachments is regarded as a symptom of mental disorders such as anti-social disorders, schizophrenia and autism. Studying the mechanisms underlying social attachment requires an animal model that displays behaviors similar to that of human social attachment. Prairie voles (Microtus ochrogaster) have become an important model for the study of the neurobiology of social attachment. In the field, male and female prairie voles form long-term, monogamous bonds and share a nest throughout the breeding season. Such a breeding pair typically remains together until one animal dies. Given that mating in prairie voles induces neuroadaptations that eventually lead to bonding, we propose here to investigate whether mating induced social bonding has an underlying epigenetic basis. Our preliminary data support this hypothesis.

项目摘要社交依恋是人类健康行为的重要组成部分，也是一种无法这种依恋被认为是精神障碍的症状，如反社会障碍、精神分裂症和自闭症。研究其作用机制潜在的社会依恋需要一个能显示行为的动物模型类似于人类的社会依恋。草原田鼠(Microtus Ochrogaster) 已经成为研究社会的神经生物学的一个重要模型依恋。在野外，雄性和雌性草原田鼠形成长期的，一夫一妻制的纽带，在整个繁殖季节共享一个巢。这样的一个繁殖的一对通常保持在一起，直到其中一只动物死亡。鉴于这种交配在草原田鼠身上诱导神经适应，最终导致结合，我们建议在这里研究交配诱导的社会纽带是否潜在的表观遗传学基础。我们的初步数据支持这一假设。