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PREPARE OS: An observational study of mother-offspring dyads from a randomized trial of a prepregnancy weight loss intervention

PREPARE OS: An observational study of mother-offspring dyads from a randomized trial of a prepregnancy weight loss intervention
PREPARE OS:一项针对孕前减肥干预随机试验的母子二人组的观察性研究
批准号:
9767405
负责人:
ERIN S LEBLANC
金额:
$42.61万
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-07-01 至 2021-08-31

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项目成果

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中文摘要
翻译
项目摘要/摘要: 肥胖症是一种全国性的流行病,没有减弱的迹象。2011年美国国立卫生研究院肥胖战略计划 研究强调了研究新的预防和治疗方案的必要性,我们回应了 这一呼吁是在2014年与Prepare随机对照试验(NIDDK R01DK0099882)进行的。因为 母亲在怀孕和怀孕早期的体重、饮食和体力活动影响代谢环境 在胎儿开始发育的过程中,准备干预的目标是帮助 超重或肥胖改善饮食和体力活动习惯并在成为 怀孕了。该干预基于行为矫正范式,利用基于电话的 由健康教练和个性化网站进行咨询。因此,它可以在任何 并在区域和/或国家范围内实施。该项目以前曾帮助女性减肥。 避免在怀孕早期过度增加妊娠体重。此外,参与者还对 非常有利的程序。我们假设怀孕前对女性进行干预是 打破了肥胖的多代循环。然而,准备试验数据收集在交付时结束。 准备观察(OS)队列研究将随着试验的结束而开始,使我们能够跟随 妇女及其子女在分娩后3年内。这项研究将包括一次面对面的研究访问 产后3年及产后3年病历重量的收集与分析 确定准备干预对体重、饮食模式和体力活动的长期影响 母亲和她们的后代的水平。如果它被证明长期有效,我们的干预将是 这是打破肥胖症多代循环的宝贵工具。
英文摘要
PROJECT SUMMARY/ABSTRACT: Obesity is a national epidemic that shows no sign of abating. The 2011 Strategic Plan for NIH Obesity Research stressed the need for research on new prevention and treatment programs, and we responded to this call in 2014 with the PREPARE randomized, controlled trial (NIDDK R01DK0099882). Because mothers’ weight, diet, and physical activity at conception and in early pregnancy impact the metabolic milieu in which the fetus starts its development, the goal of the PREPARE intervention is to help women who are overweight or have obesity improve diet and physical activity habits and lose weight prior to becoming pregnant. The intervention, which is based on the behavior modification paradigm, utilizes telephone-based counseling conducted by health coaches as well as a personalized website. Thus, it can be delivered in any location and implemented regionally and/or nationally. The program has helped women lose weight before pregnancy and avoid excessive gestational weight gain in early pregnancy. In addition, participants rate the program very favorably. We hypothesize that intervening on women before pregnancy is the key to breaking the multigenerational cycle of obesity. However, PREPARE trial data collection ends at delivery. The PREPARE Observational (OS) cohort study would begin as the trial winds down, allowing us to follow women and their offspring for 3 years after delivery. The study would include an in-person research visit at 3 years and the collection and analysis of medical record weights for 3 years after delivery in order to determine the longer-term effect of the PREPARE intervention on weight, diet patterns, and physical activity levels of mothers and their offspring. Should it prove effective over the long term, our intervention would be a valuable tool in disrupting the multigenerational cycle of obesity.
期刊论文(1)
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会议论文
DOI: 10.1002/jbmr.4613
发表时间: 2022-07
期刊: JOURNAL OF BONE AND MINERAL RESEARCH
影响因子: 6.2
作者: [LeBlanc, Erin S., Hovey, Kathleen M., Cauley, Jane A., Stefanick, Marcia, Peragallo, Rachel, Naughton, Michelle J., Andrews, Christopher A., Crandall, Carolyn J.]
通讯作者: Crandall, Carolyn J.
Sleep for Health: A randomized clinical trial examining the effects of cognitive behavioral therapy for insomnia on diabetes risk
PrepareD: Examining post-Delivery maternal-offspring obesity and metabolic risk after a prepregnancy weight-loss intervention
PrepareD: Examining post-Delivery maternal-offspring obesity and metabolic risk after a prepregnancy weight-loss intervention
PrepareD: Examining post-Delivery maternal-offspring obesity and metabolic risk after a prepregnancy weight-loss intervention
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