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PREPARE OS: An observational study of mother-offspring dyads from a randomized trial of a prepregnancy weight loss intervention

PREPARE OS: An observational study of mother-offspring dyads from a randomized trial of a prepregnancy weight loss intervention
PREPARE OS:一项针对孕前减肥干预随机试验的母子二人组的观察性研究
批准号:
9767405
负责人:
ERIN S LEBLANC
金额:
$42.61万
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-07-01 至 2021-08-31

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中文摘要
翻译
项目总结/摘要: 肥胖是一种全国性的流行病,没有减弱的迹象。2011年NIH肥胖战略计划 研究强调了研究新的预防和治疗方案的必要性, 2014年,该研究通过NIDDK R 01 DK 0099882随机对照试验进行。因为 母亲在受孕时和怀孕早期的体重、饮食和体力活动会影响代谢环境 在胎儿开始发育的时候,干预的目标是帮助那些 超重或有肥胖改善饮食和体育活动习惯,并在成为 怀孕了干预,这是基于行为矫正范式,利用电话为基础的 由健康教练进行的咨询以及个性化网站。因此,它可以以任何方式交付。 并在区域和/或国家一级执行。该项目以前曾帮助女性减肥 怀孕,避免怀孕早期体重过度增加。此外,参与者对 方案非常有利。我们假设在怀孕前对妇女进行干预是 打破肥胖的多代循环。然而,在分娩时结束了对CINEE试验数据的收集。 随着试验的结束,将开始观察性(OS)队列研究 女性及其子女在分娩后3年内。该研究将包括一次亲自研究访问, 收集并分析分娩后3年的病历权重, 确定健康教育干预对体重、饮食模式和身体活动的长期影响 母亲及其后代的水平。如果长期有效,我们的干预将是 这是一个打破肥胖多代循环的宝贵工具。
英文摘要
PROJECT SUMMARY/ABSTRACT: Obesity is a national epidemic that shows no sign of abating. The 2011 Strategic Plan for NIH Obesity Research stressed the need for research on new prevention and treatment programs, and we responded to this call in 2014 with the PREPARE randomized, controlled trial (NIDDK R01DK0099882). Because mothers’ weight, diet, and physical activity at conception and in early pregnancy impact the metabolic milieu in which the fetus starts its development, the goal of the PREPARE intervention is to help women who are overweight or have obesity improve diet and physical activity habits and lose weight prior to becoming pregnant. The intervention, which is based on the behavior modification paradigm, utilizes telephone-based counseling conducted by health coaches as well as a personalized website. Thus, it can be delivered in any location and implemented regionally and/or nationally. The program has helped women lose weight before pregnancy and avoid excessive gestational weight gain in early pregnancy. In addition, participants rate the program very favorably. We hypothesize that intervening on women before pregnancy is the key to breaking the multigenerational cycle of obesity. However, PREPARE trial data collection ends at delivery. The PREPARE Observational (OS) cohort study would begin as the trial winds down, allowing us to follow women and their offspring for 3 years after delivery. The study would include an in-person research visit at 3 years and the collection and analysis of medical record weights for 3 years after delivery in order to determine the longer-term effect of the PREPARE intervention on weight, diet patterns, and physical activity levels of mothers and their offspring. Should it prove effective over the long term, our intervention would be a valuable tool in disrupting the multigenerational cycle of obesity.
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DOI: 10.1002/jbmr.4613
发表时间: 2022-07
期刊: JOURNAL OF BONE AND MINERAL RESEARCH
影响因子: 6.2
作者: [LeBlanc, Erin S., Hovey, Kathleen M., Cauley, Jane A., Stefanick, Marcia, Peragallo, Rachel, Naughton, Michelle J., Andrews, Christopher A., Crandall, Carolyn J.]
通讯作者: Crandall, Carolyn J.
Sleep for Health: A randomized clinical trial examining the effects of cognitive behavioral therapy for insomnia on diabetes risk
PrepareD: Examining post-Delivery maternal-offspring obesity and metabolic risk after a prepregnancy weight-loss intervention
PrepareD: Examining post-Delivery maternal-offspring obesity and metabolic risk after a prepregnancy weight-loss intervention
PrepareD: Examining post-Delivery maternal-offspring obesity and metabolic risk after a prepregnancy weight-loss intervention
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