The role of estradiol in the menopause

描述（由申请人提供）：候选人的声明：候选人在妇女健康，内分泌学和流行病学方面有广泛的培训和研究经验。她的近期目标是将她的专业领域扩展到神经科学和遗传流行病学，并巩固她在临床研究方面的培训。最终，她希望在性激素和更年期领域开展独立的研究事业。为了实现她的目标，她将参加神经科学，遗传学和临床研究的正式和非正式教学，并实施研究部分所述的研究。环境：俄勒冈州健康科学大学（OHSU）是该州唯一的医学院，并有很强的研究和培训的传统。本研究将利用OHSU综合临床研究中心，该中心是一个12，500平方英尺的设施，包括一个核心实验室（具有各种分析仪器，包括专业遗传学设备），生物营养单元和计算中心。研究项目：总体目标是描述绝经过渡期和雌激素补充期间发生的激素、认知和躯体变化。在目标1中，我们将对围绝经期妇女进行观察性研究，以确定症状、睡眠、情绪和认知与雌二醇水平之间的关系以及雌二醇水平的变化。在目标2中，我们将进行一项随机对照试验，以区分雌激素替代治疗引起的认知、睡眠和情绪的变化是否是由于更年期症状的缓解。在目标3中，我们将寻求参与雌二醇合成和代谢的蛋白质变体（功能基因序列变异）与绝经事件（包括雌二醇水平，症状，睡眠，情绪，认知和对雌激素补充剂的反应）之间的关联。

DESCRIPTION (provided by applicant): Candidate's Statement: The candidate has extensive training and research experience in women's health, endocrinology, and epidemiology. Her immediate goals are to expand her field of expertise into neuroscience and genetic epidemiology and to solidify her training in clinical research. Ultimately, she wants to launch an independent research career in the field of sex hormones and the menopause. To accomplish her goals, she will attend formal and informal didactics in neuroscience, genetics, and clinical research and implement the studies described under the research section. Environment: Oregon Health Sciences University (OHSU) is the only medical school in the state, and has a strong tradition of research and training. This study will utilize the OHSU General Clinical Research Center, which is a 12,500 square foot facility that includes a Core Laboratory (with a wide array of analytical instruments including specialized genetics equipment), bionutrition unit, and computing center. Research Project: The overall goal is to characterize the hormonal, cognitive, and somatic changes that occur during the menopausal transition and during estrogen supplementation. In Aim 1, we will conduct an observational study of perimenopausal women to determine the relationship between symptoms, sleep, mood, and cognition and estradiol levels and change in estradiol levels. In Aim 2, we will perform a randomized controlled trial to differentiate whether the changes in cognition, sleep, and mood that occur with estrogen replacement are due to menopausal symptom relief. In Aim 3, we will seek associations between protein variants (functional gene sequence variations) involved in estradiol synthesis and metabolism and action and menopausal events (including estradiol levels, symptoms, sleep, mood, cognition, and response to estrogen supplementation).