The role of estradiol in the menopause

应聘者描述(由申请人提供)：应聘者陈述：应聘者在妇女健康、内分泌学和流行病学方面有丰富的培训和研究经验。她的近期目标是将自己的专业领域扩展到神经科学和遗传流行病学，并巩固她在临床研究方面的培训。最终，她想在性激素和更年期领域开始一项独立的研究事业。为了实现她的目标，她将参加神经科学、遗传学和临床研究的正式和非正式教学，并实施研究部分中描述的研究。环境：俄勒冈健康科学大学(OHSU)是该州唯一的医学院，拥有深厚的研究和培训传统。这项研究将利用OHSU综合临床研究中心，这是一个12,500平方英尺的设施，包括一个核心实验室(拥有一系列分析仪器，包括专门的遗传学设备)、生物营养部和计算中心。研究项目：总体目标是描述更年期过渡和补充雌激素期间发生的荷尔蒙、认知和躯体变化。在目标1中，我们将对围绝经期妇女进行一项观察性研究，以确定症状、睡眠、情绪、认知和雌二醇水平以及雌二醇水平变化之间的关系。在目标2中，我们将进行一项随机对照试验，以区分雌激素替代治疗后认知、睡眠和情绪的变化是否源于更年期症状的缓解。在目标3中，我们将寻找参与雌激素合成和代谢的蛋白质变异(功能基因序列变异)和行动与更年期事件(包括雌激素水平、症状、睡眠、情绪、认知和对雌激素补充的反应)之间的联系。

DESCRIPTION (provided by applicant): Candidate's Statement: The candidate has extensive training and research experience in women's health, endocrinology, and epidemiology. Her immediate goals are to expand her field of expertise into neuroscience and genetic epidemiology and to solidify her training in clinical research. Ultimately, she wants to launch an independent research career in the field of sex hormones and the menopause. To accomplish her goals, she will attend formal and informal didactics in neuroscience, genetics, and clinical research and implement the studies described under the research section. Environment: Oregon Health Sciences University (OHSU) is the only medical school in the state, and has a strong tradition of research and training. This study will utilize the OHSU General Clinical Research Center, which is a 12,500 square foot facility that includes a Core Laboratory (with a wide array of analytical instruments including specialized genetics equipment), bionutrition unit, and computing center. Research Project: The overall goal is to characterize the hormonal, cognitive, and somatic changes that occur during the menopausal transition and during estrogen supplementation. In Aim 1, we will conduct an observational study of perimenopausal women to determine the relationship between symptoms, sleep, mood, and cognition and estradiol levels and change in estradiol levels. In Aim 2, we will perform a randomized controlled trial to differentiate whether the changes in cognition, sleep, and mood that occur with estrogen replacement are due to menopausal symptom relief. In Aim 3, we will seek associations between protein variants (functional gene sequence variations) involved in estradiol synthesis and metabolism and action and menopausal events (including estradiol levels, symptoms, sleep, mood, cognition, and response to estrogen supplementation).