A high-performance unshielded wearable brain-computer interface based on microfabricated total-field OPMs

项目概述：该项目的长远目标是开发一种可穿戴的高性能脑磁图 一种可以在没有外部屏蔽的情况下运行的系统，将导致人类神经科学和 在我们对人脑的理解上取得了变革性的进展，这是在行动和背景中 目前无法通过活体人体成像技术实现。有两个具体的目标：目标1是一个小的- UMEG传感器的规模、概念验证开发以验证一种新的非侵入性非接触式非制冷 基于全场光泵磁强计的非屏蔽式磁传感器系统。目标2是一个 利用uMEG系统进行小规模人体研究以产生初步结果。在这里，我们将设计和 在健康成年人中验证基于uMEG的闭环式脑机接口(BCI)系统。证据是- 原理样机系统将是第一个柔性阵列的全场光泵磁力仪(OPM) 这有可能实现真正可穿戴的脑磁图系统，用于行为活跃的人类神经成像 允许在更自然的环境中成像期间在空间/地方移动，同时保持高 决议。该系统将引领下一代高性能非侵入式闭环式可穿戴设备 神经接口，可用于控制假肢、计算机和其他辅助和治疗 脑损伤后用于研究、诊断、修复、增强或恢复认知运动能力的设备 神经系统疾病。

Project Summary: The broad, long-term goal of this project is to develop a wearable high performance MEG system that can operate without external shielding that will lead to Advances in Human Neuroscience and transformative advances in our understanding of the Human Brain ‘in Action and in Context’, which are currently unachievable via imaging technologies in live persons. There are two specific aims: Aim 1 is a Small- scale, proof-of-concept development of uMEG Sensors to validate a novel non-invasive contactless uncooled unshielded magnetic sensor system based on total-field optically-pumped magnetometers (tOPM). Aim 2 is a small-scale human study to generate preliminary results with the uMEG system. Here, we will design and validate a closed-loop uMEG-based brain-computer interface (BCI) system in healthy adults. The proof-of- principle prototype system will be the first flexible array of total-field optically-pumped magnetometers (OPMs) that has the potential to enable a truly wearable MEG system for behaviorally active human neuroimaging that allows for movement in space/place during imaging in more natural environments while maintaining high resolution. This system will lead to next generation high-performance non-invasive closed-loop wearable neural interfaces that can be used to control prosthetics, computers and other assistive and therapeutic devices to study, diagnose, repair, augment, or restore cognitive-motor capabilities after brain injury or neurological disease.