A high-performance unshielded wearable brain-computer interface based on microfabricated total-field OPMs

项目概述：本项目的广泛、长期目标是开发一种可穿戴的高性能MEG 系统可以在没有外部屏蔽的情况下运行，这将导致人类神经科学的进步， 我们对人脑“在行动和情境中”的理解取得了革命性的进展， 这是目前通过活体成像技术无法实现的。有两个具体目标：目标1是一个小- uMEG传感器的大规模概念验证开发，以验证一种新型非侵入式非接触式非冷却 基于总场光泵磁力计（tOPM）的非屏蔽磁传感器系统。目标2是一个 小规模的人类研究，以产生初步的结果与uMEG系统。在这里，我们将设计和 在健康成人中验证基于uMEG的闭环脑机接口（BCI）系统。证据 原理原型系统将是第一个全场光泵磁力计（OPM）的灵活阵列 这有可能使一个真正的可穿戴MEG系统的行为活跃的人类神经成像， 允许在更自然的环境中成像期间在空间/位置中移动，同时保持高的 分辨率该系统将导致下一代高性能的非侵入式闭环可穿戴设备 神经接口，可用于控制假肢，计算机和其他辅助和治疗 用于研究、诊断、修复、增强或恢复脑损伤后认知运动能力的器械，或 神经系统疾病

Project Summary: The broad, long-term goal of this project is to develop a wearable high performance MEG system that can operate without external shielding that will lead to Advances in Human Neuroscience and transformative advances in our understanding of the Human Brain ‘in Action and in Context’, which are currently unachievable via imaging technologies in live persons. There are two specific aims: Aim 1 is a Small- scale, proof-of-concept development of uMEG Sensors to validate a novel non-invasive contactless uncooled unshielded magnetic sensor system based on total-field optically-pumped magnetometers (tOPM). Aim 2 is a small-scale human study to generate preliminary results with the uMEG system. Here, we will design and validate a closed-loop uMEG-based brain-computer interface (BCI) system in healthy adults. The proof-of- principle prototype system will be the first flexible array of total-field optically-pumped magnetometers (OPMs) that has the potential to enable a truly wearable MEG system for behaviorally active human neuroimaging that allows for movement in space/place during imaging in more natural environments while maintaining high resolution. This system will lead to next generation high-performance non-invasive closed-loop wearable neural interfaces that can be used to control prosthetics, computers and other assistive and therapeutic devices to study, diagnose, repair, augment, or restore cognitive-motor capabilities after brain injury or neurological disease.