A high-performance unshielded wearable brain-computer interface based on microfabricated total-field OPMs

项目摘要：该项目的广泛、长期目标是开发可穿戴的高性能 MEG 可以在没有外部屏蔽的情况下运行的系统，这将导致人类神经科学的进步 我们对人脑“在行动中和在情境中”的理解取得了革命性的进步， 目前通过活人成像技术无法实现。有两个具体目标： 目标 1 是一个小目标 uMEG 传感器的规模化、概念验证开发，以验证新型非侵入式非接触式非制冷 基于全场光泵磁力计（tOPM）的非屏蔽磁传感器系统。目标 2 是 使用 uMEG 系统进行小规模人体研究以产生初步结果。在这里，我们将设计并 在健康成人中验证基于 uMEG 的闭环脑机接口 (BCI) 系统。证明- 原理原型系统将是第一个灵活的全场光泵磁力计（OPM）阵列 有潜力实现真正可穿戴的 MEG 系统，用于行为活跃的人类神经成像 允许在更自然的环境中成像期间在空间/地点移动，同时保持高 分辨率。该系统将带来下一代高性能非侵入式闭环可穿戴设备 可用于控制假肢、计算机和其他辅助和治疗的神经接口 用于研究、诊断、修复、增强或恢复脑损伤或脑损伤后认知运动能力的设备 神经系统疾病。

Project Summary: The broad, long-term goal of this project is to develop a wearable high performance MEG system that can operate without external shielding that will lead to Advances in Human Neuroscience and transformative advances in our understanding of the Human Brain ‘in Action and in Context’, which are currently unachievable via imaging technologies in live persons. There are two specific aims: Aim 1 is a Small- scale, proof-of-concept development of uMEG Sensors to validate a novel non-invasive contactless uncooled unshielded magnetic sensor system based on total-field optically-pumped magnetometers (tOPM). Aim 2 is a small-scale human study to generate preliminary results with the uMEG system. Here, we will design and validate a closed-loop uMEG-based brain-computer interface (BCI) system in healthy adults. The proof-of- principle prototype system will be the first flexible array of total-field optically-pumped magnetometers (OPMs) that has the potential to enable a truly wearable MEG system for behaviorally active human neuroimaging that allows for movement in space/place during imaging in more natural environments while maintaining high resolution. This system will lead to next generation high-performance non-invasive closed-loop wearable neural interfaces that can be used to control prosthetics, computers and other assistive and therapeutic devices to study, diagnose, repair, augment, or restore cognitive-motor capabilities after brain injury or neurological disease.