Training and Mentoring in Neurocognitive Mechanisms of Eating Disorders

饮食失调神经认知机制的培训和指导

• 批准号: 9789697
• 负责人: JOANNA E STEINGLASS
• 金额: $ 12.31万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-20 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9789697
• 关键词: Address; Adolescent; Adult; Anorexia Nervosa; Attention; Avoidance Learning; Award; Behavior; Behavioral Mechanisms; Behavioral Research; Biological Markers; Biomedical Research; Brain; Choice Behavior; Clinical; Clinical Investigator; Clinical Research; Cognitive; Collaborations; Complement; Complex; Computational Science; Computer Simulation; Computing Methodologies; Corpus striatum structure; Cues; Data Analytics; Decision Making; Development; Diffusion; Dorsal; Eating; Eating Disorders; Evaluation; Eye; Faculty; Food; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Generations; Goals; Habits; Health Care Costs; Human; Individual; Knowledge; Lead; Learning; Link; Longitudinal Studies; Measures; Medical Students; Mental disorders; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Modeling; Neurobiology; Neurocognitive; Neurosciences; Operant Conditioning; Pathway interactions; Pilot Projects; Postdoctoral Fellow; Process; Program Development; Psychological reinforcement; Public Health; Research; Research Personnel; Research Training; Rewards; Role; Scientist; System; Teenagers; Testing; Time; Training; Training Programs; United States National Institutes of Health; Wages; Work; base; biobehavior; brain behavior; career; cognitive neuroscience; experience; functional MRI scan; gaze; improved; interest; mortality; neural circuit; neuromechanism; novel; patient oriented research; pre-doctoral; programs; recruit; relating to nervous system; research and development; sensory stimulus; skills; tool

The overall aim of this K24 Mid-Career Investigator Award in Patient-Oriented Research, “Training and Mentoring in Neurocognitive Mechanisms of Eating Disorders,” is to allow me (Joanna Steinglass MD) to continue to expand my programmatic line of clinical research and mentoring in eating disorders. My work examines the neural mechanisms of Anorexia Nervosa (AN) and develops mechanism-based novel treatment approaches. The field of eating disorders in general, and AN in particular, has an urgent need for more biobehavioral research, and I am well poised to mentor aspiring clinical investigators in this understudied field. Advances in neuroscience create a timely opportunity for a new generation of clinical work identifying biomarkers and treatment targets. I have built a program of research that involves close collaboration with world-class cognitive neuroscientists, and examines the link between brain and behavior in adolescents and adults with AN. This work has opened new avenues of research for the field, and numerous new collaborators have sought my mentorship. Through this K24, I will develop the skills to examine the brain in more sophisticated ways, learning cutting edge skills in cognitive neuroscience, emphasizing computational approaches, and applying them to the study of AN. My currently funded research includes two conceptually- linked R01s examining neural mechanisms of food choice. This K24 will leverage that work to support current mentees and develop new mentorship opportunities. The Research Plan will serve as a platform for the development of mentees, and for advancing my research to pursue future funding in mechanisms of illness and treatment. The training plan includes participation in advanced seminars, collaborations with established and new colleagues to apply new methodologies to the study of AN, and advanced training in relevant computational science. The Mentoring Plan emphasizes new efforts with post-doctoral trainees (psychiatric residents and fellows) and continuation of efforts with trainees at various levels of development: pre-doctoral trainees (medical students), and junior faculty. Through my activities it is hoped that the understanding of the neurobiological underpinnings of AN will improve, and these advances in mechanism will lead to opportunities for development of new treatments. I will contribute to these advances through my research and collaborations with colleagues, and through my training of future clinical investigators.

这个K24中期职业研究者奖的总体目标是以患者为导向的研究，“培训和 指导饮食失调的神经认知机制，”是让我（乔安娜Steinglass医学博士）， 继续扩大我在饮食失调方面的临床研究和指导计划。我的工作 研究神经性厌食症（AN）的神经机制，并开发基于机制的新治疗方法 接近。一般来说，饮食失调领域，特别是AN，迫切需要更多的 生物行为研究，我很好地准备指导有抱负的临床研究人员在这个欠研究领域。 神经科学的进步为新一代的临床工作创造了及时的机会， 生物标志物和治疗靶点。我已经建立了一个研究计划，涉及密切合作， 世界级的认知神经科学家，并研究大脑和青少年行为之间的联系， 成人AN这项工作为该领域的研究开辟了新的途径， 寻求我的指导。通过这个K24，我将开发的技能，以检查大脑在更多的 复杂的方式，学习认知神经科学的尖端技能，强调计算 方法，并将其应用于AN的研究。我目前资助的研究包括两个概念- 研究食物选择的神经机制。K24将利用这项工作来支持当前的 并开发新的指导机会。该研究计划将作为一个平台， 学员的发展，并推进我的研究，以寻求未来的资金在疾病的机制 和治疗。 培训计划包括参加高级研讨会，与现有和新的 同事们应用新的方法来研究AN，并在相关的计算先进的培训， 科学指导计划强调与博士后学员（精神病住院医师和 研究员），并继续努力培养不同发展水平的学员：博士前学员 （医学生）和初级教师。希望通过我的活动， AN的神经生物学基础将得到改善，这些机制的进展将带来机会 用于开发新的治疗方法。我将通过我的研究和合作为这些进步做出贡献 通过我对未来临床研究者的培训。