Administrative Core

总结 P01计划的核心目的是支持涉及独立调查人员的综合研究， 分享研究能力和资源，实现共同目标。这项工作的关键是科学的严谨性， 在研究工作的各个方面的可重复性。为此，行政核心将监督 建议书各方面的性能，并提供统计支持，以确保适当的设计和 实验分析。核心小组提出了以下具体目标： 具体目标1：管理所有与计划相关的行政活动。 核心A将负责管理预算，编制非竞争性续延， 与NIH的沟通，财政监督，资金的支付，以及对 项目和核心。 具体目标2：为通过项目开展的试验工作提供统计支持。 核心A将负责确保在所有领域进行严格和透明的研究， P01。这将包括适当的实验设计，包括功效和样本量 计算、建模和考虑相关生物变量的数据分析。核心A 将侧重于在所有与赠款有关的活动中遵守重复性标准。 具体目标3：保持对适当法规的遵守。 核心A将确保所有项目和核心符合脊椎动物实验管理法规 动物、生物安全、去识别人类标本和其他相关的联邦、州、地方和机构 规定 具体目标4：协调、安排和领导所有科学会议。 核心A将协调科学会议，以最大限度地提高项目之间的互动， 持续的研究努力，并确保有效利用核心。核心A将每月组织和领导 P01领导层和各自实验室成员的会议，并将协调年度 与科学咨询委员会的会议。

SUMMARY The central purpose of a P01 Program is to support integrated research involving independent investigators who share research capabilities and resources toward a common goal. Essential to this effort is scientific rigor and reproducibility in all aspects of the research effort. To accomplish this, the Administrative Core will oversee the performance of all aspects of the proposal and provide statistical support to ensure the appropriate design and analysis of experiments. The Core proposes the following Specific Aims: Specific Aim 1: Manage all program-related administrative activities. Core A will be responsible for management of the budget, preparation of non-competing renewals, communication with the NIH, fiscal oversight, disbursement of funds, and general scientific oversight of the Projects and Cores. Specific Aim 2: Provide statistical support for the experimental efforts conducted through the Projects. Core A will be responsible for ensuring statistically-rigorous and transparent research in all areas supported by the P01. This will include statistically-appropriate experimental design, including power and sample size calculations, and modeling and data analysis that considers relevant biological variables. Additionally, Core A will focus on adherence to reproducibility standards in all grant-related activities. Specific Aim 3: Maintain compliance with appropriate regulations. Core A will ensure that all Projects and Cores comply with regulations governing experimentation with vertebrate animals, biosafety, deidentified human specimens and other relevant federal, state, local, and institutional regulations. Specific Aim 4: Coordinate, schedule, and lead all scientific meetings. Core A will coordinate scientific meetings to maximize interactions between Projects, provide critical input into ongoing research efforts, and ensure effective utilization of Cores. Core A will organize and lead monthly meetings of the P01 leadership and members of their respective laboratories, and will coordinate annual meetings with the Scientific Advisory Board.