Transgenerational work exposures, EDCs and male fertility

跨代工作暴露、EDC 和男性生育能力

• 批准号: 9791314
• 负责人: JOHN D MEYER
• 金额: $ 8.48万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2020-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9791314
• 关键词: Transgenerational; work; exposures; EDCs; male

Project Summary Male infertility and subfertility accounts for roughly half of the 10-15% prevalence of overall failure to conceive a child. An accumulated body of evidence across the past two decades suggests fetal origins of adult male reproductive dysfunction. Male reproductive dysfunction could proceed inter- generationally, with parental work contributing to male subfertility in the next generation, and increased vulnerability to second insult in the adult male exposed in utero or via parental occupation. We will use data on male reproductive parameters, occupational data, and relevant covariates collected by the Study for Future Families (SFF) to examine the role of occupational contributions to depression of male fertility indices including semen quality parameters, male hormonal levels, and testicular size measurements. Occupational exposure indices will include reported occupation, specific job exposures reported in the SFF, and a job-exposure matrix describing exposure to endocrine-disrupting chemicals. Additionally, using a unique set of maternal questionnaire data on occupational exposures, we will assess intergenerational influences on men's reproductive indices by modeling direct and mediated effects of both parental and male-partner occupational exposures on male fertility profiles. This will assess male vulnerability (arising from parental occupational exposure) to a second insult to reproductive capacity. This proposal is one of the first to examine the role of occupational exposures sustained by parents of male subjects in reduced fertility or susceptibility to insult from occupational exposures in the subsequent generation. The richness of this dataset, combined with the linkage of male fertility parameters with parental occupational data, is an opportunity to test of a novel hypothesis on intergenerational transmission of male subfecudity. The findings of this proposed study will lay the groundwork for efforts to reduce potentially hazardous occupational exposures in both fertile men and women across generations. This proposal addresses the NORA cross-sector program in Cancer, Reproductive and Cardiovascular Diseases which, with other CDC partners, aims to better identify and control reproductive toxicant exposures, and is relevant to the health of workers in the Healthcare, Manufacturing, and Construction NORA sectors. As the NIOSH Program Portfolio notes, the overall contribution of occupational exposures to male and female infertility remains unknown; this effort will make a significant contribution toward a research agenda on male and intergenerational workplace exposures and fertility. The work supports NIOSH r2p initiatives in providing detailed information on adverse reproductive exposures in the workplace, and their mitigation, as well as increasing protection of workers who may be at greater risk from prior parental exposures.

项目摘要 男性不育症和不育症约占总不育症患病率的10%-15% 怀上一个孩子。过去二十年来积累的大量证据表明胎儿起源 成年男性生殖功能障碍。男性生殖功能障碍可能会在 从世代来看，父母的工作有助于下一代男性的亚生育，并增加 在子宫内或通过父母职业暴露的成年男性易受二次侮辱。我们将使用 收集的关于男性生殖参数、职业数据和相关协变量的数据 未来家庭研究(SFF)探讨职业对男性抑郁的影响 生育指标包括精液质量参数、男性荷尔蒙水平和睾丸大小 测量。职业暴露指数将包括报告的职业、具体的工作暴露 在SFF中报告，以及描述接触内分泌扰乱化学品的工作暴露矩阵。 此外，使用一套独特的关于职业暴露的产妇问卷数据，我们将 通过直接建模和中介建模评估代际对男性生殖指数的影响 父母和男性伴侣的职业暴露对男性生育状况的影响。这将是 评估男性对第二次侮辱的脆弱性(由父母的职业暴露引起) 生殖能力。这项提案是第一批研究职业暴露的作用的提案之一。 生育能力降低或易受职业侮辱的男性受试者的父母 在下一代中曝光。该数据集的丰富性，与 男性生育参数和父母的职业数据是检验新假说的机会 论男性低繁殖力的代际传递。这项拟议研究的结果将为 努力减少生育男子和妇女潜在危险职业暴露的基础工作 不同世代的女性。这项提案涉及Nora癌症跨部门计划， 生殖和心血管疾病，与疾控中心的其他合作伙伴一起，旨在更好地识别和 控制生殖毒物暴露，并与医疗保健工作者的健康有关， 制造业和建筑业。正如NIOSH计划组合所指出的那样，总体 职业暴露对男性和女性不孕症的贡献尚不清楚；这一努力将 对关于男性和代际工作场所的研究议程做出重大贡献 暴露和生育能力。该工作支持NIOSH R2P计划提供有关以下方面的详细信息 工作场所的有害生殖暴露及其缓解和加强保护 可能因父母先前的暴露而面临更大风险的工人。