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Frontal cholinergic signals during value-based decision-making

基于价值的决策过程中的额叶胆碱能信号

基本信息

批准号：
9789948
负责人：
CHUN-HAY ALEX KWAN
金额：
$ 25.13万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-21 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9789948
关键词：
Acetylcholine Animals Arousal Axon Behavior Behavioral Calcium Cells Cognitive Cues Data Decision Making Detection Discrimination Disease Environment Event Exposure to Fire - disasters Goals Head Health Human Image Impairment Implant Knock-in Lasers Learning Link Location Measures Memory Methods Modeling Motor Cortex Mus Neocortex Neuromodulator Perception Process Psychological reinforcement Punishment Reporting Research Resolution Rewards Rodent Role Sampling Sensory Signal Transduction Site Specificity Surface Task Performances Testing Theoretical model Time Update Virus Visual Cortex basal forebrain base cell type cholinergic cholinergic neuron classical conditioning cognitive function cranium design experimental study flexibility frontal lobe innovation insight learning progression novel novel strategies relating to nervous system sample fixation two-photon vigilance

项目摘要

PROJECT SUMMARY Cortical cholinergic signaling is implicated in diverse functions, including arousal and vigilance, signaling of reinforcements, and learning and memory. There is also evidence suggesting cholinergic contributions to value-based decisions. However, decision-making is an elaborate process, influenced by parameters such as value functions, learning rates, reward prediction errors, and so on. Still poorly understood is the extent to which cholinergic signaling may report or regulate specific decision-related parameters. In preliminary studies, we developed a novel adaptation of a value-based decision-making task for head-fixed mice. Analysis and reinforcement learning model fit of the task performance indicate behavior consistent with value-based decisions. In this proposal, we will determine the neural encoding in cortical cholinergic axons by measuring their activity dynamics in the rodent premotor cortex during decision-making (Aim 1). We will determine the influence of fast cholinergic signaling on value-based decisions by manipulating acetylcholine release in the neocortex (Aim 2). Because neuromodulators such as acetylcholine have considerable influence on multiple facets of decision-making, the proposed studies to delineate its computational function will provide insights into the neural basis of value-based decisions.

项目概要皮质胆碱能信号传导涉及多种功能，包括唤醒和警惕、强化、学习和记忆。还有证据表明胆碱能有助于基于价值的决策。然而，决策是一个复杂的过程，受到诸如以下参数的影响：价值函数、学习率、奖励预测误差等等。人们对其程度仍知之甚少胆碱能信号传导可以报告或调节特定的决策相关参数。在初步研究中，我们为头部固定小鼠开发了一种基于价值的决策任务的新颖改编。分析与任务绩效的强化学习模型拟合表明行为与基于价值的一致决定。在这个提案中，我们将通过测量来确定皮质胆碱能轴突的神经编码决策过程中啮齿动物前运动皮层的活动动态（目标 1）。我们将确定通过操纵乙酰胆碱的释放，快速胆碱能信号对基于价值的决策的影响新皮质（目标 2）。因为乙酰胆碱等神经调节剂对多种神经调节剂有相当大的影响。决策的各个方面，拟议的描述其计算功能的研究将为以下方面提供见解基于价值的决策的神经基础。