Cellular basis of psilocybin actions in frontal cortex
额叶皮层裸盖菇素作用的细胞基础
基本信息
- 批准号:10516272
- 负责人:
- 金额:$ 59.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-19 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:Antidepressive AgentsApicalArchitectureAttentionBehaviorBehavioralBiologicalBrainChronic stressCognitionConsciousDendritic SpinesDoseExposure toGoalsHTR2A geneHalf-LifeHallucinogensHeadImageKetamineKnock-outMajor Depressive DisorderMeasuresMedialMediatingMental disordersMoodsMusNeocortexNeuronal PlasticityNeuronsPerceptionPyramidal TractsReceptor CellResolutionRodentSeriesSerotonin Receptor 5-HT2ASerotonin Receptor 5-HT2CSignal TransductionStressStructureTestingTherapeuticVertebral columnVirusantidepressant effectbasecell typeconditional knockoutdensityearly phase clinical trialexperimental studyfrontal lobehippocampal pyramidal neuronin vivoinsightneurobiological mechanismneuropsychiatric disordernoveloptical imagingreceptorrelating to nervous systemresponseretrograde transportserotonin receptortwo photon microscopytwo-photon
项目摘要
PROJECT SUMMARY
Psychedelics are compounds that produce an atypical state of consciousness characterized by altered
perception, cognition, and mood. Among psychedelics, psilocybin has gained attention recently because early
clinical trials indicated potential antidepressant effects, leading to a ‘breakthrough therapy’ designation from the
FDA to test psilocybin for major depressive disorder. However, despite the promise, the biological mechanisms
underpinning psilocybin’s potential therapeutic action are poorly understood. Our lab employs subcellular-
resolution two-photon microscopy to visualize dendritic structure and function in head-fixed mice. The goal of
this project is to characterize how a single dose of psilocybin may alter dendritic architecture in the medial
frontal cortex of the mouse and the associated cellular mechanisms. The hypothesis is that psilocybin
promotes spine formation by activating specific serotonin receptor subtypes and exerts differential effects on
distinct subtypes of pyramidal neurons. To test the hypothesis, we propose a series of experiments that
combine subcellular-resolution optical imaging, conditional knockouts, and causal perturbations in mice. The
results will answer crucial questions regarding psilocybin’s ability to promote structural plasticity in vivo and
delineate receptors and cellular factors that underlie the plasticity-promoting actions. We expect the
mechanistic insights will be important as the field evaluates psychedelics as a potential treatment option for
neuropsychiatric disorders and searches for novel antidepressants.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CHUN-HAY ALEX KWAN其他文献
CHUN-HAY ALEX KWAN的其他文献
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{{ truncateString('CHUN-HAY ALEX KWAN', 18)}}的其他基金
A Dendritic Substrate for Fast-Acting Antidepressant Action
具有快速抗抑郁作用的树突状基质
- 批准号:
10755878 - 财政年份:2022
- 资助金额:
$ 59.83万 - 项目类别:
Cellular basis of psilocybin actions in frontal cortex
额叶皮层裸盖菇素作用的细胞基础
- 批准号:
10686230 - 财政年份:2022
- 资助金额:
$ 59.83万 - 项目类别:
A Dendritic Substrate for Fast-Acting Antidepressant Action
具有快速抗抑郁作用的树突状基质
- 批准号:
10623145 - 财政年份:2022
- 资助金额:
$ 59.83万 - 项目类别:
A Dendritic Substrate for Fast-Acting Antidepressant Action
具有快速抗抑郁作用的树突状基质
- 批准号:
10386910 - 财政年份:2020
- 资助金额:
$ 59.83万 - 项目类别:
A Dendritic Substrate for Fast-Acting Antidepressant Action
具有快速抗抑郁作用的树突状基质
- 批准号:
10188646 - 财政年份:2020
- 资助金额:
$ 59.83万 - 项目类别:
Frontal cholinergic signals during value-based decision-making
基于价值的决策过程中的额叶胆碱能信号
- 批准号:
9789948 - 财政年份:2018
- 资助金额:
$ 59.83万 - 项目类别:
Structural plasticity basis of fast-acting antidepressant action
速效抗抑郁作用的结构可塑性基础
- 批准号:
9291526 - 财政年份:2016
- 资助金额:
$ 59.83万 - 项目类别:
Cortical GABAergic Circuits in Alzheimer's Disease
阿尔茨海默病中的皮质 GABA 能回路
- 批准号:
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- 资助金额:
$ 59.83万 - 项目类别:
Cortical GABAergic Circuits in Alzheimer's Disease
阿尔茨海默病中的皮质 GABA 能回路
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8849045 - 财政年份:
- 资助金额:
$ 59.83万 - 项目类别:
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