Neural mechanisms involved in contextual processing in PTSD

参与 PTSD 情境处理的神经机制

基本信息

  • 批准号:
    10378188
  • 负责人:
  • 金额:
    $ 5.09万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-05-24 至 2021-11-30
  • 项目状态:
    已结题

项目摘要

Summary/Abstract Posttraumatic stress disorder (PTSD) is a serious and debilitating condition, characterized by changes in fear expression and modulation. The fear modulation deficits in PTSD patients likely stem, at least in part, from difficulties using “safe” and “danger” contexts to disambiguate potentially threatening cues. A number of cognitive deficits may underlie impaired contextual processing in PTSD, including deficits in encoding and retrieval of contextual information. Pattern separation (ability to distinguish between similar but different stimuli) and pattern completion (ability to identify a previously encoded stimulus based on partial information) are believed to underlie memory encoding and retrieval, respectively. The goal of this project is to systematically probe memory function, like pattern separation and pattern completion in PTSD patients, trauma exposed controls (TC), and healthy controls (HC) using neurocognitive tasks and a fear learning task. We will investigate the roles of memory for context and pattern separation/completion in the modulation of fear expression. We aim to examine 1) Pattern Separation and Pattern Completion abilities in PTSD and the underlying neural circuits, and 2) Relationships between Pattern Separation and Pattern Completion abilities and context processing deficits during fear learning in PTSD. Participants will complete a fear learning task to assess contextual processing and fear modulation. Memory for contextual information, pattern separation, and pattern completion will be examined during MRI scanning to identify associated hippocampal and prefrontal cortex activation patterns. Brain activation and behavioral performance will be compared between PTSD, TC, and HC groups across all tasks to better understand contributions of these hippocampal deficits to altered fear learning and reactivity in PTSD. In order to successfully complete the proposed project, training objectives include 1) advanced MRI processing and analysis, 2) hippocampal mechanisms of learning and memory, 3) neurocognitive assessment of PTSD, and 4) clinical translational neuroscience. This proposed NIMH K23 award will provide rich pilot data for an R-level application and protected time for the candidate to obtain advanced training in neuroimaging methods, while broadening her expertise in neurocognitive mechanisms underlying anxiety disorder presentations. The outcome of this project has strong potential to enhance our understanding of mechanisms involved in PTSD development and maintenance, to eventually improve existing treatments.
摘要/文摘

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Altered resting-state functional connectivity in adolescents is associated with PTSD symptoms and trauma exposure
  • DOI:
    10.1016/j.nicl.2020.102215
  • 发表时间:
    2020-02
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Jony Sheynin;Jony Sheynin;E. Duval;Yana Lokshina;Yana Lokshina;J. C. Scott;Mike Angstadt;Daniel A Kessler;Li Zhang;Li Zhang;R. E. Gur;R. Gur;Israel Liberzon;Israel Liberzon
  • 通讯作者:
    Jony Sheynin;Jony Sheynin;E. Duval;Yana Lokshina;Yana Lokshina;J. C. Scott;Mike Angstadt;Daniel A Kessler;Li Zhang;Li Zhang;R. E. Gur;R. Gur;Israel Liberzon;Israel Liberzon
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Elizabeth Duval其他文献

Elizabeth Duval的其他文献

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{{ truncateString('Elizabeth Duval', 18)}}的其他基金

A mechanistic investigation of risk factors for opioid use disorder: Examining hippocampal-based context-dependent learning and memory associated with adverse childhood experiences
阿片类药物使用障碍危险因素的机制研究:检查与不良童年经历相关的基于海马的情境依赖学习和记忆
  • 批准号:
    10707793
  • 财政年份:
    2023
  • 资助金额:
    $ 5.09万
  • 项目类别:
Neural Mechanisms Involved in Contextual Processing in PTSD
参与 PTSD 情境处理的神经机制
  • 批准号:
    9974590
  • 财政年份:
    2017
  • 资助金额:
    $ 5.09万
  • 项目类别:

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Behavioral Insights on Cooperation in Social Dilemmas
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  • 批准年份:
    2024
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    万元
  • 项目类别:
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