Neural mechanisms involved in contextual processing in PTSD
参与 PTSD 情境处理的神经机制
基本信息
- 批准号:10378188
- 负责人:
- 金额:$ 5.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-24 至 2021-11-30
- 项目状态:已结题
- 来源:
- 关键词:Anxiety DisordersBehavioralBrainChronicClinicalCognitive deficitsControl GroupsCuesDataDevelopmentFrightFutureGoalsHippocampus (Brain)ImpairmentLearningMRI ScansMagnetic Resonance ImagingMaintenanceMemoryMentored Patient-Oriented Research Career Development AwardMethodsNational Institute of Mental HealthNeurocognitiveOutcomeParticipantPatientsPatternPerformancePost-Traumatic Stress DisordersPrefrontal CortexRetrievalRoleStimulusTimeTrainingbasecognitive trainingimprovedmemory encodingmemory retrievalmilitary serviceneural circuitneuroimagingneuromechanismservice memberstemtranslational neurosciencetrauma exposuretraumatic event
项目摘要
Summary/Abstract
Posttraumatic stress disorder (PTSD) is a serious and debilitating condition, characterized by changes in fear
expression and modulation. The fear modulation deficits in PTSD patients likely stem, at least in part, from
difficulties using “safe” and “danger” contexts to disambiguate potentially threatening cues. A number of
cognitive deficits may underlie impaired contextual processing in PTSD, including deficits in encoding and
retrieval of contextual information. Pattern separation (ability to distinguish between similar but different
stimuli) and pattern completion (ability to identify a previously encoded stimulus based on partial information)
are believed to underlie memory encoding and retrieval, respectively. The goal of this project is to
systematically probe memory function, like pattern separation and pattern completion in PTSD patients, trauma
exposed controls (TC), and healthy controls (HC) using neurocognitive tasks and a fear learning task. We will
investigate the roles of memory for context and pattern separation/completion in the modulation of fear
expression. We aim to examine 1) Pattern Separation and Pattern Completion abilities in PTSD and the
underlying neural circuits, and 2) Relationships between Pattern Separation and Pattern Completion
abilities and context processing deficits during fear learning in PTSD. Participants will complete a fear
learning task to assess contextual processing and fear modulation. Memory for contextual information, pattern
separation, and pattern completion will be examined during MRI scanning to identify associated hippocampal
and prefrontal cortex activation patterns. Brain activation and behavioral performance will be compared
between PTSD, TC, and HC groups across all tasks to better understand contributions of these hippocampal
deficits to altered fear learning and reactivity in PTSD. In order to successfully complete the proposed project,
training objectives include 1) advanced MRI processing and analysis, 2) hippocampal mechanisms of
learning and memory, 3) neurocognitive assessment of PTSD, and 4) clinical translational
neuroscience. This proposed NIMH K23 award will provide rich pilot data for an R-level application and
protected time for the candidate to obtain advanced training in neuroimaging methods, while broadening her
expertise in neurocognitive mechanisms underlying anxiety disorder presentations. The outcome of this project
has strong potential to enhance our understanding of mechanisms involved in PTSD development and
maintenance, to eventually improve existing treatments.
总结/摘要
创伤后应激障碍(PTSD)是一种严重的、使人衰弱的病症,其特征是恐惧的变化
表达和调节。PTSD患者的恐惧调节缺陷可能至少部分源于
难以使用"安全"和"危险"上下文来消除潜在威胁线索的歧义。一些
认知缺陷可能是PTSD中受损的上下文处理的基础,包括编码缺陷和
检索上下文信息。模式分离(区分相似但不同的
刺激)和模式完成(基于部分信息识别先前编码的刺激的能力)
被认为分别是记忆编码和提取的基础。该项目的目标是
系统地探索记忆功能,如PTSD患者的模式分离和模式完成,创伤
暴露对照(TC)和健康对照(HC),使用神经认知任务和恐惧学习任务。我们将
研究背景记忆和模式分离/完成在恐惧调制中的作用
表情我们的目的是检查1)模式分离和模式完成能力的创伤后应激障碍和
潜在的神经回路,以及2)模式分离和模式完成之间的关系
PTSD患者在恐惧学习过程中的能力和背景处理缺陷。参与者将完成一个恐惧
学习任务,以评估上下文处理和恐惧调制。对上下文信息、模式的记忆
在MRI扫描期间将检查分离和模式完成,以识别相关的海马
和前额叶皮层激活模式大脑激活和行为表现将进行比较
在所有任务中PTSD,TC和HC组之间进行比较,以更好地了解这些海马神经元的贡献。
恐惧学习和反应能力的改变。为了顺利完成拟议项目,
培训目标包括1)先进的MRI处理和分析,2)海马机制,
学习和记忆,3)PTSD的神经认知评估,以及4)临床转化
神经科学NIMH K23项目将为R级应用提供丰富的试验数据,
保护候选人获得神经成像方法高级培训的时间,同时扩大她的
焦虑症表现背后的神经认知机制的专业知识。该项目的成果
有很强的潜力,以提高我们的理解机制参与创伤后应激障碍的发展,
最终改善现有的治疗方法。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Altered resting-state functional connectivity in adolescents is associated with PTSD symptoms and trauma exposure
- DOI:10.1016/j.nicl.2020.102215
- 发表时间:2020-02
- 期刊:
- 影响因子:0
- 作者:Jony Sheynin;Jony Sheynin;E. Duval;Yana Lokshina;Yana Lokshina;J. C. Scott;Mike Angstadt;Daniel A Kessler;Li Zhang;Li Zhang;R. E. Gur;R. Gur;Israel Liberzon;Israel Liberzon
- 通讯作者:Jony Sheynin;Jony Sheynin;E. Duval;Yana Lokshina;Yana Lokshina;J. C. Scott;Mike Angstadt;Daniel A Kessler;Li Zhang;Li Zhang;R. E. Gur;R. Gur;Israel Liberzon;Israel Liberzon
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{{ truncateString('Elizabeth Duval', 18)}}的其他基金
A mechanistic investigation of risk factors for opioid use disorder: Examining hippocampal-based context-dependent learning and memory associated with adverse childhood experiences
阿片类药物使用障碍危险因素的机制研究:检查与不良童年经历相关的基于海马的情境依赖学习和记忆
- 批准号:
10707793 - 财政年份:2023
- 资助金额:
$ 5.09万 - 项目类别:
Neural Mechanisms Involved in Contextual Processing in PTSD
参与 PTSD 情境处理的神经机制
- 批准号:
9974590 - 财政年份:2017
- 资助金额:
$ 5.09万 - 项目类别:
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