Neural mechanisms involved in contextual processing in PTSD
参与 PTSD 情境处理的神经机制
基本信息
- 批准号:10378188
- 负责人:
- 金额:$ 5.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-24 至 2021-11-30
- 项目状态:已结题
- 来源:
- 关键词:Anxiety DisordersBehavioralBrainChronicClinicalCognitive deficitsControl GroupsCuesDataDevelopmentFrightFutureGoalsHippocampus (Brain)ImpairmentLearningMRI ScansMagnetic Resonance ImagingMaintenanceMemoryMentored Patient-Oriented Research Career Development AwardMethodsNational Institute of Mental HealthNeurocognitiveOutcomeParticipantPatientsPatternPerformancePost-Traumatic Stress DisordersPrefrontal CortexRetrievalRoleStimulusTimeTrainingbasecognitive trainingimprovedmemory encodingmemory retrievalmilitary serviceneural circuitneuroimagingneuromechanismservice memberstemtranslational neurosciencetrauma exposuretraumatic event
项目摘要
Summary/Abstract
Posttraumatic stress disorder (PTSD) is a serious and debilitating condition, characterized by changes in fear
expression and modulation. The fear modulation deficits in PTSD patients likely stem, at least in part, from
difficulties using “safe” and “danger” contexts to disambiguate potentially threatening cues. A number of
cognitive deficits may underlie impaired contextual processing in PTSD, including deficits in encoding and
retrieval of contextual information. Pattern separation (ability to distinguish between similar but different
stimuli) and pattern completion (ability to identify a previously encoded stimulus based on partial information)
are believed to underlie memory encoding and retrieval, respectively. The goal of this project is to
systematically probe memory function, like pattern separation and pattern completion in PTSD patients, trauma
exposed controls (TC), and healthy controls (HC) using neurocognitive tasks and a fear learning task. We will
investigate the roles of memory for context and pattern separation/completion in the modulation of fear
expression. We aim to examine 1) Pattern Separation and Pattern Completion abilities in PTSD and the
underlying neural circuits, and 2) Relationships between Pattern Separation and Pattern Completion
abilities and context processing deficits during fear learning in PTSD. Participants will complete a fear
learning task to assess contextual processing and fear modulation. Memory for contextual information, pattern
separation, and pattern completion will be examined during MRI scanning to identify associated hippocampal
and prefrontal cortex activation patterns. Brain activation and behavioral performance will be compared
between PTSD, TC, and HC groups across all tasks to better understand contributions of these hippocampal
deficits to altered fear learning and reactivity in PTSD. In order to successfully complete the proposed project,
training objectives include 1) advanced MRI processing and analysis, 2) hippocampal mechanisms of
learning and memory, 3) neurocognitive assessment of PTSD, and 4) clinical translational
neuroscience. This proposed NIMH K23 award will provide rich pilot data for an R-level application and
protected time for the candidate to obtain advanced training in neuroimaging methods, while broadening her
expertise in neurocognitive mechanisms underlying anxiety disorder presentations. The outcome of this project
has strong potential to enhance our understanding of mechanisms involved in PTSD development and
maintenance, to eventually improve existing treatments.
摘要/文摘
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Altered resting-state functional connectivity in adolescents is associated with PTSD symptoms and trauma exposure
- DOI:10.1016/j.nicl.2020.102215
- 发表时间:2020-02
- 期刊:
- 影响因子:0
- 作者:Jony Sheynin;Jony Sheynin;E. Duval;Yana Lokshina;Yana Lokshina;J. C. Scott;Mike Angstadt;Daniel A Kessler;Li Zhang;Li Zhang;R. E. Gur;R. Gur;Israel Liberzon;Israel Liberzon
- 通讯作者:Jony Sheynin;Jony Sheynin;E. Duval;Yana Lokshina;Yana Lokshina;J. C. Scott;Mike Angstadt;Daniel A Kessler;Li Zhang;Li Zhang;R. E. Gur;R. Gur;Israel Liberzon;Israel Liberzon
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Elizabeth Duval其他文献
Elizabeth Duval的其他文献
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{{ truncateString('Elizabeth Duval', 18)}}的其他基金
A mechanistic investigation of risk factors for opioid use disorder: Examining hippocampal-based context-dependent learning and memory associated with adverse childhood experiences
阿片类药物使用障碍危险因素的机制研究:检查与不良童年经历相关的基于海马的情境依赖学习和记忆
- 批准号:
10707793 - 财政年份:2023
- 资助金额:
$ 5.09万 - 项目类别:
Neural Mechanisms Involved in Contextual Processing in PTSD
参与 PTSD 情境处理的神经机制
- 批准号:
9974590 - 财政年份:2017
- 资助金额:
$ 5.09万 - 项目类别:
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