Surveillance and identification of variants of concern within circulating SARS-CoV-2 across Kentucky
肯塔基州流行的 SARS-CoV-2 中值得关注的变种的监测和鉴定
基本信息
- 批准号:10381183
- 负责人:
- 金额:$ 77.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAddressAgeAntibodiesAntiviral AgentsAwardBiologicalBiological AssayBlack, Indigenous, People of ColorBlood CirculationBrazilCOVID-19COVID-19 severityCOVID-19 surveillanceCessation of lifeCharacteristicsCollaborationsColorCommunicable DiseasesCommunitiesComplementCountryCountyCustomDataData SetDatabasesDepositionDetectionDevelopmentDiagnosticDiseaseEducational CurriculumEnsureEthnic OriginEthnic groupEtiologyEvolutionFemaleFrequenciesFutureFuture GenerationsGenesGeneticGenomicsGenotypeGeographic LocationsGeographyGovernment AgenciesHealth Care ResearchHealthcareImmune responseImmunoglobulinsIndividualIndustrializationInfectionInformaticsInstitutionKentuckyKnowledgeLaboratoriesLatinxMediatingMethodsMutationOutcome StudyPathogenicityPhylogenetic AnalysisPopulationPositioning AttributePrivatizationPublic HealthRNARaceReportingResistanceSARS-CoV-2 genomeSARS-CoV-2 infectionSARS-CoV-2 variantSamplingSecureSourceSouth AfricaSpecimenSurveillance ProgramTimeTrainingUnderrepresented PopulationsUnited KingdomUniversitiesVaccine DesignVaccinesVariantViralViral GenomeViral PathogenesisVirusbasebiological sexcost effectivedesigndriving forcegenomic signaturegraduate studenthealth inequalitiesimprovedinfection rateinformatics toolinterestmalemolecular sequence databasemortalityneutralizing antibodynext generationnovelpandemic diseasepathogenpopulation basedprospectiveresiliencesingle molecule real time sequencingskillssocialsocial vulnerabilitysurveillance datatransmission processundergraduate studentvariants of concernviral genomicsviral transmission
项目摘要
PROJECT SUMMARY
The emergence and circulation of SARS-CoV-2, the virus that causes COVID-19 disease, has led to >125 million
infections and more than 2.5 million deaths worldwide in just over 1 year. Global sequencing efforts have
identified several viral variants of concern (VOC) and interest (VOI) that result in increased transmission rates
and/or increased mortality for those infected with the new SARS-CoV-2 strains. Despite the development of
multiple robust and effective vaccines, further viral evolution may result in resistance to current levels of vaccine-
mediated protection. Ongoing viral genomic surveillance is necessary to identify and characterize known and
new viral variants, to inform both ongoing public health efforts, and future vaccine design strategies. This is a
particularly urgent need for Institutional Development Award (IDeA) states, for which knowledge of circulating
SARS-CoV-2 variants is extremely limited. The mechanistic forces driving SARS-CoV-2 diversification and
variant emergence are certainly multifactorial. Effective natural and vaccine antiviral protection is thought to be
mediated by potent, broadly reactive neutralizing antibodies (nAbs). Recently developed genotyping assays have
characterized the extensive diversity within immunoglobulin (IG) loci, with increasing evidence suggesting that
the collective array of genes that encode antibody repertories differ widely across ethnic populations. Moreover,
recent reports suggest that biological sex may impact immunopathogenesis and individual resilience, and that
geographically restricted circulation and transmission of variants, along with pre-existing social vulnerabilities
may also impact SARS-CoV-2 variant dynamics. It is well documented that COVID-19 disproportionately impacts
underrepresented populations, including Black, Indigenous and people of color (BIPOC) and Latinx peoples.
Data regarding SARS-CoV-2 circulation and variant profiling in these populations in also underreported in
ongoing viral surveillance efforts. Evaluating how viral VOC and VOI are impacted by differential genetic,
biological and social backgrounds will be critical for providing equitable representation of the frequency and
characteristics of SARS-CoV-2 variants, and act as a first step towards mechanistic hypothesis generation for
future studies. Using a robust, high throughput and cost-effective single molecule, real-time sequencing
approach, we propose to perform large scale SARS-CoV-2 genomic surveillance from ~7000 samples sourced
across Kentucky (KY) to (1) substantially improve data availability regarding SARS-CoV-2 dynamics and variant
circulation, (2) evaluate biological and social correlates of variant emergence and evolution, and (3) leverage
this pipeline to develop a unique curriculum in pathogen surveillance. To achieve this, we have built a multi-
institutional collaborative effort, developing key partnerships among a deep network of academic, healthcare,
and industrial stakeholders, positioning this team to establish a pathogen surveillance center for ongoing and
future efforts.
项目摘要
引起COVID-19疾病的病毒SARS-CoV-2的出现和传播已导致超过1.25亿人死亡
在短短一年多的时间里,全世界有250多万人感染和死亡。全球测序工作
确定了几种引起关注(VOC)和关注(VOI)的病毒变体,导致传播率增加
和/或增加感染新SARS-CoV-2毒株的死亡率。尽管开发了
多种强大而有效的疫苗,进一步的病毒进化可能导致对当前疫苗水平的抵抗力,
中介保护。持续的病毒基因组监测是必要的,以确定和表征已知的,
新的病毒变种,为正在进行的公共卫生工作和未来的疫苗设计策略提供信息。这是一
特别是迫切需要机构发展奖(IDEA)的国家,其中知识的流通
SARS-CoV-2变种非常有限。驱动SARS-CoV-2多样化的机械力量,
变种的出现当然是多因素的。有效的天然和疫苗抗病毒保护被认为是
由有效的广泛反应性中和抗体(nAb)介导。最近开发的基因分型测定法
免疫球蛋白(IG)基因座内的广泛多样性,越来越多的证据表明,
编码抗体库的基因的集体排列在不同种族人群中差异很大。此外,委员会认为,
最近的报告表明,生物性别可能会影响免疫发病机制和个人的适应力,
变种的传播和传播受到地理限制,沿着预先存在的社会脆弱性
也可能影响SARS-CoV-2变异动力学。有充分的证据表明,COVID-19不成比例地影响了
代表性不足的人口,包括黑人,土著人和有色人种(BIPOC)和拉丁人。
在这些人群中,关于SARS-CoV-2循环和变异特征分析的数据也报告不足。
正在进行的病毒监测工作。评估病毒VOC和VOI如何受到差异遗传的影响,
生物和社会背景将是至关重要的,以提供公平的代表性的频率和
SARS-CoV-2变异体的特征,并作为产生机制假设的第一步
未来的研究。使用稳健、高通量和具有成本效益的单分子,实时测序
方法,我们建议进行大规模的SARS-CoV-2基因组监测约7000样品来源
整个肯塔基州(KY),以(1)大幅提高有关SARS-CoV-2动态和变异的数据可用性
循环,(2)评估变异出现和进化的生物和社会相关性,以及(3)杠杆作用
这个管道开发一个独特的病原体监测课程。为了实现这一目标,我们建立了一个多-
机构合作努力,在学术,医疗保健,
和工业利益相关者,定位这个团队建立一个病原体监测中心,
未来的努力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jason A. Chesney其他文献
PFKFB3-dependent redox homeostasis and DNA repair support cell survival under EGFR-TKIs in non-small cell lung carcinoma
- DOI:
10.1186/s40170-024-00366-y - 发表时间:
2024-12-18 - 期刊:
- 影响因子:5.300
- 作者:
Nadiia Lypova;Susan M. Dougherty;Brian F. Clem;Jing Feng;Xinmin Yin;Xiang Zhang;Xiaohong Li;Jason A. Chesney;Yoannis Imbert-Fernandez - 通讯作者:
Yoannis Imbert-Fernandez
Jason A. Chesney的其他文献
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{{ truncateString('Jason A. Chesney', 18)}}的其他基金
Leveraging Zika virus driven myeloid cell responses to treat GBM
利用寨卡病毒驱动的骨髓细胞反应来治疗 GBM
- 批准号:
10891973 - 财政年份:2023
- 资助金额:
$ 77.84万 - 项目类别:
Center for Cancer Immunology and Immunotherapy (CCII)
癌症免疫学和免疫治疗中心 (CCII)
- 批准号:
10753949 - 财政年份:2020
- 资助金额:
$ 77.84万 - 项目类别:
Center for Cancer Immunology and Immunotherapy (CCII)
癌症免疫学和免疫治疗中心 (CCII)
- 批准号:
10577763 - 财政年份:2020
- 资助金额:
$ 77.84万 - 项目类别:
Center for Cancer Immunology and Immunotherapy (CCII)
癌症免疫学和免疫治疗中心 (CCII)
- 批准号:
10333205 - 财政年份:2020
- 资助金额:
$ 77.84万 - 项目类别:
Center for Cancer Immunology and Immunotherapy (CCII)
癌症免疫学和免疫治疗中心 (CCII)
- 批准号:
10093098 - 财政年份:2020
- 资助金额:
$ 77.84万 - 项目类别:
Surveillance and identification of variants of concern within circulating SARS-CoV-2 across Kentucky
肯塔基州流行的 SARS-CoV-2 中值得关注的变种的监测和鉴定
- 批准号:
10595227 - 财政年份:2020
- 资助金额:
$ 77.84万 - 项目类别:
Activation of Cyclin-Dependent Kinases by Fructose-2,6-Bisphosphate
2,6-二磷酸果糖激活细胞周期蛋白依赖性激酶
- 批准号:
8250362 - 财政年份:2011
- 资助金额:
$ 77.84万 - 项目类别:
Activation of Cyclin-Dependent Kinases by Fructose-2,6-Bisphosphate
2,6-二磷酸果糖激活细胞周期蛋白依赖性激酶
- 批准号:
8448296 - 财政年份:2011
- 资助金额:
$ 77.84万 - 项目类别:
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