Surveillance and identification of variants of concern within circulating SARS-CoV-2 across Kentucky
肯塔基州流行的 SARS-CoV-2 中值得关注的变种的监测和鉴定
基本信息
- 批准号:10381183
- 负责人:
- 金额:$ 77.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAddressAgeAntibodiesAntiviral AgentsAwardBiologicalBiological AssayBlack, Indigenous, People of ColorBlood CirculationBrazilCOVID-19COVID-19 severityCOVID-19 surveillanceCessation of lifeCharacteristicsCollaborationsColorCommunicable DiseasesCommunitiesComplementCountryCountyCustomDataData SetDatabasesDepositionDetectionDevelopmentDiagnosticDiseaseEducational CurriculumEnsureEthnic OriginEthnic groupEtiologyEvolutionFemaleFrequenciesFutureFuture GenerationsGenesGeneticGenomicsGenotypeGeographic LocationsGeographyGovernment AgenciesHealth Care ResearchHealthcareImmune responseImmunoglobulinsIndividualIndustrializationInfectionInformaticsInstitutionKentuckyKnowledgeLaboratoriesLatinxMediatingMethodsMutationOutcome StudyPathogenicityPhylogenetic AnalysisPopulationPositioning AttributePrivatizationPublic HealthRNARaceReportingResistanceSARS-CoV-2 genomeSARS-CoV-2 infectionSARS-CoV-2 variantSamplingSecureSourceSouth AfricaSpecimenSurveillance ProgramTimeTrainingUnderrepresented PopulationsUnited KingdomUniversitiesVaccine DesignVaccinesVariantViralViral GenomeViral PathogenesisVirusbasebiological sexcost effectivedesigndriving forcegenomic signaturegraduate studenthealth inequalitiesimprovedinfection rateinformatics toolinterestmalemolecular sequence databasemortalityneutralizing antibodynext generationnovelpandemic diseasepathogenpopulation basedprospectiveresiliencesingle molecule real time sequencingskillssocialsocial vulnerabilitysurveillance datatransmission processundergraduate studentvariants of concernviral genomicsviral transmission
项目摘要
PROJECT SUMMARY
The emergence and circulation of SARS-CoV-2, the virus that causes COVID-19 disease, has led to >125 million
infections and more than 2.5 million deaths worldwide in just over 1 year. Global sequencing efforts have
identified several viral variants of concern (VOC) and interest (VOI) that result in increased transmission rates
and/or increased mortality for those infected with the new SARS-CoV-2 strains. Despite the development of
multiple robust and effective vaccines, further viral evolution may result in resistance to current levels of vaccine-
mediated protection. Ongoing viral genomic surveillance is necessary to identify and characterize known and
new viral variants, to inform both ongoing public health efforts, and future vaccine design strategies. This is a
particularly urgent need for Institutional Development Award (IDeA) states, for which knowledge of circulating
SARS-CoV-2 variants is extremely limited. The mechanistic forces driving SARS-CoV-2 diversification and
variant emergence are certainly multifactorial. Effective natural and vaccine antiviral protection is thought to be
mediated by potent, broadly reactive neutralizing antibodies (nAbs). Recently developed genotyping assays have
characterized the extensive diversity within immunoglobulin (IG) loci, with increasing evidence suggesting that
the collective array of genes that encode antibody repertories differ widely across ethnic populations. Moreover,
recent reports suggest that biological sex may impact immunopathogenesis and individual resilience, and that
geographically restricted circulation and transmission of variants, along with pre-existing social vulnerabilities
may also impact SARS-CoV-2 variant dynamics. It is well documented that COVID-19 disproportionately impacts
underrepresented populations, including Black, Indigenous and people of color (BIPOC) and Latinx peoples.
Data regarding SARS-CoV-2 circulation and variant profiling in these populations in also underreported in
ongoing viral surveillance efforts. Evaluating how viral VOC and VOI are impacted by differential genetic,
biological and social backgrounds will be critical for providing equitable representation of the frequency and
characteristics of SARS-CoV-2 variants, and act as a first step towards mechanistic hypothesis generation for
future studies. Using a robust, high throughput and cost-effective single molecule, real-time sequencing
approach, we propose to perform large scale SARS-CoV-2 genomic surveillance from ~7000 samples sourced
across Kentucky (KY) to (1) substantially improve data availability regarding SARS-CoV-2 dynamics and variant
circulation, (2) evaluate biological and social correlates of variant emergence and evolution, and (3) leverage
this pipeline to develop a unique curriculum in pathogen surveillance. To achieve this, we have built a multi-
institutional collaborative effort, developing key partnerships among a deep network of academic, healthcare,
and industrial stakeholders, positioning this team to establish a pathogen surveillance center for ongoing and
future efforts.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jason A. Chesney其他文献
PFKFB3-dependent redox homeostasis and DNA repair support cell survival under EGFR-TKIs in non-small cell lung carcinoma
- DOI:
10.1186/s40170-024-00366-y - 发表时间:
2024-12-18 - 期刊:
- 影响因子:5.300
- 作者:
Nadiia Lypova;Susan M. Dougherty;Brian F. Clem;Jing Feng;Xinmin Yin;Xiang Zhang;Xiaohong Li;Jason A. Chesney;Yoannis Imbert-Fernandez - 通讯作者:
Yoannis Imbert-Fernandez
Jason A. Chesney的其他文献
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{{ truncateString('Jason A. Chesney', 18)}}的其他基金
Leveraging Zika virus driven myeloid cell responses to treat GBM
利用寨卡病毒驱动的骨髓细胞反应来治疗 GBM
- 批准号:
10891973 - 财政年份:2023
- 资助金额:
$ 77.84万 - 项目类别:
Center for Cancer Immunology and Immunotherapy (CCII)
癌症免疫学和免疫治疗中心 (CCII)
- 批准号:
10753949 - 财政年份:2020
- 资助金额:
$ 77.84万 - 项目类别:
Center for Cancer Immunology and Immunotherapy (CCII)
癌症免疫学和免疫治疗中心 (CCII)
- 批准号:
10577763 - 财政年份:2020
- 资助金额:
$ 77.84万 - 项目类别:
Center for Cancer Immunology and Immunotherapy (CCII)
癌症免疫学和免疫治疗中心 (CCII)
- 批准号:
10333205 - 财政年份:2020
- 资助金额:
$ 77.84万 - 项目类别:
Center for Cancer Immunology and Immunotherapy (CCII)
癌症免疫学和免疫治疗中心 (CCII)
- 批准号:
10093098 - 财政年份:2020
- 资助金额:
$ 77.84万 - 项目类别:
Surveillance and identification of variants of concern within circulating SARS-CoV-2 across Kentucky
肯塔基州流行的 SARS-CoV-2 中值得关注的变种的监测和鉴定
- 批准号:
10595227 - 财政年份:2020
- 资助金额:
$ 77.84万 - 项目类别:
Activation of Cyclin-Dependent Kinases by Fructose-2,6-Bisphosphate
2,6-二磷酸果糖激活细胞周期蛋白依赖性激酶
- 批准号:
8250362 - 财政年份:2011
- 资助金额:
$ 77.84万 - 项目类别:
Activation of Cyclin-Dependent Kinases by Fructose-2,6-Bisphosphate
2,6-二磷酸果糖激活细胞周期蛋白依赖性激酶
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8448296 - 财政年份:2011
- 资助金额:
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