New Mexico Clinical Trials Node: Clinical research and practice to address substance use in diverse, rural and underserved populations

新墨西哥州临床试验节点：解决多样化、农村和服务不足人群的药物使用问题的临床研究和实践

• 批准号: 10379715
• 负责人: Kimberly Page
• 金额: $ 193.67万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10379715
• 关键词: Acute Pain; Address; Adolescent; Alaska Native; American Indians; Behavior Therapy; Caring; Center for Translational Science Activities; Chronic; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Communities; Community Health; Conduct Clinical Trials; Criminal Justice; Data Science; Development; Disease; Dissemination and Implementation; Disulfiram; Education; Ensure; Epidemic; Evaluation; Evidence based practice; Geographic Locations; Goals; Harm Reduction; Health Personnel; Health Services; Heroin; Hispanic Americans; Hispanics; Informatics; Infrastructure; Institutes; Knowledge; Lead; Leadership; Link; Maternal and Child Health; Medical; Medicine; Methods; Minority Groups; Modification; Morbidity - disease rate; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; New Mexico; Outpatients; Overdose; Patients; Pharmacology; Play; Population Heterogeneity; Poverty; Prevention; Prevention Research; Prevention strategy; Primary Health Care; Protocols documentation; Provider; Public Health; Randomized Controlled Trials; Research; Research Personnel; Role; Rural; Rural Population; Site; Substance Use Disorder; Translations; Underserved Population; Unemployment; Universities; Work; Workforce Development; Youth; addiction; base; behavioral health; behavioral health intervention; care providers; clinical care; clinical practice; clinical research site; clinical trial implementation; cocaine use; community based participatory research; community engagement; disorder prevention; evidence base; experience; health care settings; health disparity; implementation research; implementation science; improved; improved outcome; innovation; knowledge base; learning network; medical specialties; medically underserved; methadone treatment; mortality; opioid epidemic; opioid misuse; opioid mortality; opioid use disorder; patient population; practice-based research network; prescription opioid; protocol development; recruit; research study; rural Hispanic; rural area; social determinants; substance use; uptake; young adult

ABSTRACT NM is an epicenter of the opioid crisis in the US, with one of the highest overdose mortality rates since 1990. Both heroin-attributable opioid deaths and deaths from prescription opioids have increased, especially in Hispanic and American Indian/Alaska Native groups. Many challenging social determinants, including poverty and unemployment contribute to high rates of OUD in NM. Our group is ideally suited to lead a NIDA CTN Node because of the breadth and depth of our involvement in OUD research, extensive clinical trials experience, intimate connection with the ECHO Institute and its use for expanding access to SUD treatments, links with AI/AN researchers and clinicians, our proven ability to recruit diverse rural populations to participate in research, as well as informatics and data science capacity. The Aims of the NM Node are to: 1) develop and maintain a highly efficient platform to conduct clinical trials that will inform evidence-based prevention and treatment of OUD; 2) collaborate on and lead research that addresses and improves outcomes across the OUD Cascade of Care (CoC); 3) promote uptake of best-practices in OUD prevention and care in NM and nationwide through effective dissemination of evidence-based innovations. The expected impacts will be expanded research in diverse, rural and underserved populations impacted by the opioid crisis, and increased capacity of providers and researchers to collaborate on, lead, and propose impactful research. NM Node research will ensure the development of robust and generalizable methods for prevention, identification, and treatment of OUD including evaluation and modification of the CoC expanding the local and national knowledge base. Our dissemination aim will ensure a productive cycle of engagement and translation of evidence-based practices and promote a sustained positive impact on the OUD CoC in communities in NM and nationwide. Our proposal builds on multiple assets: 1) a strong alliance with the primary care health providers in (i) an existing PBRN (RIOS Net) that extends into rural NM, (ii) UNM community-based primary care clinics; (iii) and providers of SUD/ and OUD treatment at multiple rural and urban sites across NM including over 400 that have engaged with ECHO learning networks; 2) 15 years of prior CTN and protocol management experience; 3) expertise conducting research including clinical trials with patients with SUD and OUD; 4) leadership in health services including Project ECHO, informatics, and implementation research; 5) access to unique and diverse communities and patient populations, including medically underserved, rural, Hispanic and American Indian; 6) strong clinical and educational expertise in MOUD and 7) our strength in behavioral interventions for SUD, centered in CASAA .

抽象的 NM是美国阿片类药物危机的震中，其过量死亡率是自1990年以来最高的。 海洛因 - 可侵蚀阿片类药物死亡和处方阿片类药物的死亡都有所增加，尤其是在 西班牙裔和美洲印第安人/阿拉斯加本土团体。许多具有挑战性的社会决定因素，包括贫困 失业率在NM中导致OUD高率。我们的小组非常适合领导NIDA CTN 由于我们参与OUD研究的广度和深度，节点是广泛的临床试验 经验，与Echo Institute的亲密联系及其用于扩展获得SUD治疗的使用， 与AI/A/A的研究人员和临床医生的联系，我们久经考验的能力招募各种农村人群参与 在研究以及信息学和数据科学能力中。 NM节点的目的是：1） 并保持一个高效的平台进行临床试验，该试验将为基于证据的预防和 Oud的处理； 2）协作和领导研究，以解决并改善整个结果 Oud Cascade of Care（COC）； 3）在NM和 通过有效传播基于证据的创新，在全国范围内。预期的影响将是 在受阿片类药物危机影响的各种，农村和服务不足的人群中的研究扩大，并增加了 提供者和研究人员合作，领导和提出有影响力的研究的能力。 NM节点 研究将确保开发可预防，识别和可推广的方法 OUD的处理，包括评估和修改COC扩展本地和国家 知识库。我们的传播目的将确保参与和翻译的有效循环 基于证据的实践，并促进NM社区的OUD COC持续积极影响 和全国。我们的提议以多种资产为基础：1）与初级保健健康的强大联盟 （i）现有的PBRN（RIOS Net）的提供商，该PBRN（RIOS NET）延伸到农村NM，（ii）基于社区的主要基础 护理诊所； （iii）NM多个农村和城市地点的SUD/和OUD处理的提供者 包括400多个与回声学习网络互动的； 2）先前的CTN和协议15年 管理经验； 3）进行研究的专业知识，包括与SUD患者和 Oud; 4）卫生服务领导力，包括项目回声，信息学和实施研究； 5） 获得独特和多样化的社区和患者人群，包括医疗服务不足，农村 西班牙裔和美洲印第安人； 6）MOUD的强大临床和教育专业知识和7）我们的实力 SUD的行为干预措施，以CASAA为中心。