New Mexico Clinical Trials Node: Clinical research and practice to address substance use in diverse, rural and underserved populations

新墨西哥州临床试验节点：解决多样化、农村和服务不足人群的药物使用问题的临床研究和实践

• 批准号: 10583148
• 负责人: Kimberly Page
• 金额: $ 35.85万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10583148
• 关键词: Acute Pain; Address; Adolescent; Alaska Native; American Indians; Behavior Therapy; Caring; Center for Translational Science Activities; Chronic; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Cocaine use disorder; Communities; Community Health; Conduct Clinical Trials; Criminal Justice; Data Science; Development; Dissemination and Implementation; Disulfiram; Education; Ensure; Epidemic; Evaluation; Evidence based practice; Geographic Locations; Goals; Harm Reduction; Health Personnel; Health Services; Heroin; Hispanic; Hispanic Americans; Informatics; Infrastructure; Institutes; Knowledge; Lead; Leadership; Link; Maternal and Child Health; Medical; Medicine; Methods; Minority Groups; Modification; Morbidity - disease rate; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; New Mexico; Outpatients; Overdose; Patients; Pharmaceutical Preparations; Pharmacology; Play; Population Heterogeneity; Poverty; Prevention; Prevention Research; Prevention strategy; Primary Health Care; Protocols documentation; Provider; Public Health; Randomized Controlled Trials; Reduce health disparities; Research; Research Personnel; Role; Rural; Rural Population; Site; Substance Use Disorder; Translations; Underserved Population; Unemployment; Universities; Work; Workforce Development; Youth; addiction; base; behavioral health; behavioral health intervention; care providers; clinical care; clinical practice; clinical research site; clinical trial implementation; community based participatory research; community engagement; disorder prevention; evidence base; experience; health care settings; implementation research; implementation science; improved; improved outcome; innovation; knowledge base; learning network; medical specialties; medically underserved; methadone treatment; mortality; opioid epidemic; opioid misuse; opioid mortality; opioid use disorder; patient population; practice-based research network; prescription opioid; protocol development; recruit; research study; rural Hispanic; rural area; social determinants; substance use; uptake; young adult

ABSTRACT NM is an epicenter of the opioid crisis in the US, with one of the highest overdose mortality rates since 1990. Both heroin-attributable opioid deaths and deaths from prescription opioids have increased, especially in Hispanic and American Indian/Alaska Native groups. Many challenging social determinants, including poverty and unemployment contribute to high rates of OUD in NM. Our group is ideally suited to lead a NIDA CTN Node because of the breadth and depth of our involvement in OUD research, extensive clinical trials experience, intimate connection with the ECHO Institute and its use for expanding access to SUD treatments, links with AI/AN researchers and clinicians, our proven ability to recruit diverse rural populations to participate in research, as well as informatics and data science capacity. The Aims of the NM Node are to: 1) develop and maintain a highly efficient platform to conduct clinical trials that will inform evidence-based prevention and treatment of OUD; 2) collaborate on and lead research that addresses and improves outcomes across the OUD Cascade of Care (CoC); 3) promote uptake of best-practices in OUD prevention and care in NM and nationwide through effective dissemination of evidence-based innovations. The expected impacts will be expanded research in diverse, rural and underserved populations impacted by the opioid crisis, and increased capacity of providers and researchers to collaborate on, lead, and propose impactful research. NM Node research will ensure the development of robust and generalizable methods for prevention, identification, and treatment of OUD including evaluation and modification of the CoC expanding the local and national knowledge base. Our dissemination aim will ensure a productive cycle of engagement and translation of evidence-based practices and promote a sustained positive impact on the OUD CoC in communities in NM and nationwide. Our proposal builds on multiple assets: 1) a strong alliance with the primary care health providers in (i) an existing PBRN (RIOS Net) that extends into rural NM, (ii) UNM community-based primary care clinics; (iii) and providers of SUD/ and OUD treatment at multiple rural and urban sites across NM including over 400 that have engaged with ECHO learning networks; 2) 15 years of prior CTN and protocol management experience; 3) expertise conducting research including clinical trials with patients with SUD and OUD; 4) leadership in health services including Project ECHO, informatics, and implementation research; 5) access to unique and diverse communities and patient populations, including medically underserved, rural, Hispanic and American Indian; 6) strong clinical and educational expertise in MOUD and 7) our strength in behavioral interventions for SUD, centered in CASAA .

抽象的 新墨西哥州是美国阿片类药物危机的中心，是 1990 年以来用药过量死亡率最高的州之一。 海洛因引起的阿片类药物死亡和处方阿片类药物死亡均有所增加，特别是在 西班牙裔和美洲印第安人/阿拉斯加原住民群体。许多具有挑战性的社会决定因素，包括贫困 和失业率导致新墨西哥州 OUD 率较高。我们的团队非常适合领导 NIDA CTN 节点是因为我们参与 OUD 研究的广度和深度、广泛的临床试验 经验、与 ECHO 研究所的密切联系及其用于扩大 SUD 治疗的机会， 与 AI/AN 研究人员和临床医生的联系，我们已证明有能力招募不同的农村人口参与 研究以及信息学和数据科学能力。 NM 节点的目标是： 1）开发 并维持一个高效的平台来进行临床试验，为循证预防和预防提供信息 OUD 治疗； 2）合作并领导研究，以解决和改善整个领域的成果 OUD 级联护理 (CoC)； 3) 促进新墨西哥州采用 OUD 预防和护理最佳实践， 通过在全国范围内有效传播基于证据的创新。预计影响将是 扩大了对受阿片类药物危机影响的多样化、农村和服务不足人群的研究，并增加 提供者和研究人员合作、领导和提出有影响力的研究的能力。网管节点 研究将确保开发出稳健且可推广的预防、识别和预防方法 OUD 的处理，包括评估和修改 CoC，扩大地方和国家范围 知识库。我们的传播目标将确保参与和翻译的有效循环 循证实践，促进 OUD CoC 在新墨西哥州社区产生持续的积极影响 和全国范围内。我们的建议建立在多项资产的基础上：1) 与初级保健卫生部门建立强有力的联盟 (i) 延伸至新墨西哥州农村地区的现有 PBRN (RIOS Net)，(ii) 新墨西哥州以社区为基础的小学 护理诊所； (iii) 以及新墨西哥州多个农村和城市地点的 SUD/和 OUD 治疗提供者 包括超过 400 名参与 ECHO 学习网络的人； 2) 15 年之前的 CTN 和协议 管理经验； 3) 进行研究的专业知识，包括对 SUD 患者进行临床试验； 沉香木； 4) 卫生服务领域的领导力，包括 ECHO 项目、信息学和实施研究； 5） 接触独特和多样化的社区和患者群体，包括医疗服务不足的社区、农村、 西班牙裔和美洲印第安人； 6) 在 MOUD 方面强大的临床和教育专业知识以及 7) 我们在 SUD 的行为干预，以 CASAA 为中心。