New Mexico Clinical Trials Node: Clinical research and practice to address substance use in diverse, rural and underserved populations

新墨西哥州临床试验节点：解决多样化、农村和服务不足人群的药物使用问题的临床研究和实践

• 批准号: 10581505
• 负责人: Kimberly Page
• 金额: $ 107.18万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10581505
• 关键词: Acute Pain; Address; Adolescent; Agreement; Alaska Native; American Indians; Behavior Therapy; Behavioral; Caring; Center for Translational Science Activities; Cessation of life; Child Health; Chronic; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Cocaine use disorder; Collaborations; Communities; Community Health; Conduct Clinical Trials; Criminal Justice; Data Science; Dedications; Development; Dissemination and Implementation; Disulfiram; Education; Ensure; Epidemic; Evaluation; Evidence based practice; Geographic Locations; Goals; Harm Reduction; Health Personnel; Health Services; Heroin; Hispanic; Informatics; Infrastructure; Intervention; Knowledge; Lead; Leadership; Link; Maternal and Child Health; Medical; Medicine; Methods; Minority Groups; Modification; Morbidity - disease rate; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; New Mexico; Outpatients; Overdose; Patients; Play; Population Heterogeneity; Poverty; Prevention; Prevention Research; Prevention strategy; Primary Care; Primary Health Care; Productivity; Protocols documentation; Provider; Public Health; Randomized, Controlled Trials; Reduce health disparities; Research; Research Personnel; Role; Rural; Rural Population; Site; Substance Use Disorder; Translations; Underserved Population; Unemployment; Universities; Work; Workforce Development; Youth; addiction; behavioral health; behavioral health intervention; care providers; clinical care; clinical implementation; clinical practice; clinical research site; clinical trial implementation; community based participatory research; community engagement; disorder prevention; evidence base; experience; forging; health care settings; implementation research; implementation science; improved; improved outcome; innovation; knowledge base; learning network; medical specialties; medically underserved; medication for opioid use disorder; methadone treatment; mortality; opioid epidemic; opioid misuse; opioid mortality; opioid use disorder; patient population; pharmacologic; practice-based research network; prescription opioid; primary care clinic; primary care practice; protocol development; recruit; research study; rural area; social determinants; substance use; uptake; young adult

ABSTRACT NM is an epicenter of the opioid crisis in the US, with one of the highest overdose mortality rates since 1990. Both heroin-attributable opioid deaths and deaths from prescription opioids have increased, especially in Hispanic and American Indian/Alaska Native groups. Many challenging social determinants, including poverty and unemployment contribute to high rates of OUD in NM. Our group is ideally suited to lead a NIDA CTN Node because of the breadth and depth of our involvement in OUD research, extensive clinical trials experience, intimate connection with the ECHO Institute and its use for expanding access to SUD treatments, links with AI/AN researchers and clinicians, our proven ability to recruit diverse rural populations to participate in research, as well as informatics and data science capacity. The Aims of the NM Node are to: 1) develop and maintain a highly efficient platform to conduct clinical trials that will inform evidence-based prevention and treatment of OUD; 2) collaborate on and lead research that addresses and improves outcomes across the OUD Cascade of Care (CoC); 3) promote uptake of best-practices in OUD prevention and care in NM and nationwide through effective dissemination of evidence-based innovations. The expected impacts will be expanded research in diverse, rural and underserved populations impacted by the opioid crisis, and increased capacity of providers and researchers to collaborate on, lead, and propose impactful research. NM Node research will ensure the development of robust and generalizable methods for prevention, identification, and treatment of OUD including evaluation and modification of the CoC expanding the local and national knowledge base. Our dissemination aim will ensure a productive cycle of engagement and translation of evidence-based practices and promote a sustained positive impact on the OUD CoC in communities in NM and nationwide. Our proposal builds on multiple assets: 1) a strong alliance with the primary care health providers in (i) an existing PBRN (RIOS Net) that extends into rural NM, (ii) UNM community-based primary care clinics; (iii) and providers of SUD/ and OUD treatment at multiple rural and urban sites across NM including over 400 that have engaged with ECHO learning networks; 2) 15 years of prior CTN and protocol management experience; 3) expertise conducting research including clinical trials with patients with SUD and OUD; 4) leadership in health services including Project ECHO, informatics, and implementation research; 5) access to unique and diverse communities and patient populations, including medically underserved, rural, Hispanic and American Indian; 6) strong clinical and educational expertise in MOUD and 7) our strength in behavioral interventions for SUD, centered in CASAA .

摘要

项目成果

Injection partnership characteristics and HCV status associations with syringe and equipment sharing among people who inject drugs.

• DOI: 10.1186/s12889-023-16133-5
• 发表时间: 2023-06-20
• 期刊: BMC public health
• 影响因子: 4.5

Screening for opioid use disorder and co-occurring depression and post-traumatic stress disorder in primary care in New Mexico.

在新墨西哥州的初级保健中筛查阿片类药物使用障碍和同时发生的抑郁症和创伤后应激障碍。

• DOI: 10.1186/s13722-023-00362-5
• 发表时间: 2023-01-27
• 期刊: ADDICTION SCIENCE & CLINICAL PRACTICE
• 影响因子: 3.7
• 作者: Murray-Krezan, Cristina;Dopp, Alex;Tarhuni, Lina;Carmody, Mary D. D.;Becker, Kirsten;Anderson, Jessica;Komaromy, Miriam;Meredith, Lisa S. S.;Watkins, Katherine E. E.;Wagner, Katherine;Page, Kimberly
• 通讯作者: Page, Kimberly