GC-Tfh cell differentiation
GC-Tfh cell differentiation
批准号:
10374924
负责人:
Hui Hu
金额:
$18.56万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-03-19 至 2024-02-29
关键词:
ASCL2 geneAddressAntibody ResponseAutoimmune DiseasesB-LymphocytesBLR1 geneBiological ModelsCD4 Positive T LymphocytesCandidate Disease GeneCell Differentiation processCellsChromatinConfusionDataDendritic CellsGenesHelix-Turn-Helix MotifsHelper-Inducer T-LymphocyteHumoral ImmunitiesImmune responseIn VitroKineticsKnowledgeLeadLibrariesLightMaintenanceMemoryModelingMusPlayPopulationProcessReportingResearchRoleStructure of germinal center of lymph nodeT memory cellWorkinfectious disease treatmentinfluenza infectionmemory CD4 T lymphocytemouse modelmultipotent cellnovelpandemic diseaseprogrammed cell death protein 1public health relevanceresponsetranscription factortranscriptomevaccine development
中文摘要
项目摘要
CD 4+滤泡辅助性T细胞(Tfh)是生殖中心(GC)反应和长期免疫反应所必需的。
术语体液免疫。已经提出Tfh细胞分化是一个多阶段过程,
包括PD-1+ CXCR 5 + pre-Tfh和PD-1hiCXCR 5 hi生发中心Tfh(GC-Tfh)细胞的步骤。
然而,大多数研究一直使用广义的“CXCR 5 + Tfh”细胞,其开始
变得过于简单,并可能导致混淆-特别是关于GC-Tfh细胞分化
和记忆
树突状细胞激活幼稚CD 4 + T细胞并启动Tfh细胞分化,包括Tfh细胞分化。
诱导CXCR 5表达。GC-Tfh细胞的进一步分化需要与B的相互作用
细胞我们的初步结果表明,前Tfh细胞不是简单的维持,
实质上进一步分化为GC-Tfh细胞。然而,在很大程度上,
关于这种前Tfh到GC-Tfh转变的机制。在本申请中,我们的目标是
鉴定前Tfh至GC-Tfh细胞分化中新调节剂。与此同时,我们还将建立新的
模型系统来研究GC-Tfh记忆。我们的建议有可能提供重要的
关于如何控制体液免疫应答以治疗感染性疾病的知识,
自身免疫性疾病,并帮助疫苗开发新的大流行威胁。
英文摘要
Project Summary
CD4+ T follicular helper (Tfh) cells are essential for germinal center (GC) responses and long-
term humoral immunity. It has been proposed that Tfh cell differentiation is a multi-stage process that
includes steps of PD-1+CXCR5+ pre-Tfh and PD-1hiCXCR5hi germinal center Tfh (GC-Tfh) cells.
However, most studies have been using the broadly defined “CXCR5+ Tfh” cells, which starts to
become too simplistic and may lead to confusion—particularly regarding the GC-Tfh cell differentiation
and memory.
Dendritic cells activate naïve CD4+ T cells and initiate Tfh cell differentiation including the
induction of CXCR5 expression. The further GC-Tfh cell differentiation requires interactions with B
cells. Our preliminary results suggest that instead of simple maintenance, pre-Tfh cells undergo
substantial further differentiation to become GC-Tfh cells. To a large extent, however, little is known
about the mechanism underlying this pre-Tfh to GC-Tfh transition. In this application, we aim to
identify novel regulators in pre-Tfh to GC-Tfh cell differentiation. Meanwhile, we will also establish new
model systems to study GC-Tfh memory. Our proposal has the potential to provide important
knowledge on how to control the humoral immune response for the treatment of infectious diseases,
autoimmune disorders, and to aid vaccine development for new pandemic threats.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Transcriptional Regulation of CD4+ T Cell Differentiation and Diversified Memory
-
批准号:10714458
-
项目类别:
-
资助金额:$50.79万
-
财政年份:2023
-
负责人:Hui Hu
-
依托单位:
Transcriptional Regulation of CD4+ T Cell Differentiation and Diversified Memory
-
批准号:10741301
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项目类别:
-
资助金额:$32.5万
-
财政年份:2022
-
负责人:Hui Hu
-
依托单位:
Hypertensive Disorders of Pregnancy and Early Risk of Maternal CVD: Influence of the External Exposome
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批准号:10645046
-
项目类别:
-
资助金额:$15.88万
-
财政年份:2021
-
负责人:Hui Hu
-
依托单位:
Hypertensive Disorders of Pregnancy and Early Risk of Maternal CVD: Influence of the External Exposome
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批准号:10523580
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项目类别:
-
资助金额:$13.41万
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财政年份:2021
-
负责人:Hui Hu
-
依托单位:
Hypertensive Disorders of Pregnancy and Early Risk of Maternal CVD: Influence of the External Exposome
-
批准号:10214088
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项目类别:
-
资助金额:$3.31万
-
财政年份:2021
-
负责人:Hui Hu
-
依托单位:
Hypertensive Disorders of Pregnancy and Early Risk of Maternal CVD: Influence of the External Exposome
-
批准号:10414064
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项目类别:
-
资助金额:$16.72万
-
财政年份:2021
-
负责人:Hui Hu
-
依托单位:
Hypertensive Disorders of Pregnancy and Early Risk of Maternal CVD: Influence of the External Exposome
-
批准号:10771766
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项目类别:
-
资助金额:$6.35万
-
财政年份:2021
-
负责人:Hui Hu
-
依托单位:
Regulation of Tfh cell differentiation and humoral immunity
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批准号:10165471
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项目类别:
-
资助金额:$49.16万
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财政年份:2017
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负责人:Hui Hu
-
依托单位:
Transcriptional regulation of T cell quiescience and activation
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批准号:8872018
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项目类别:
-
资助金额:$36.75万
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财政年份:2012
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负责人:Hui Hu
-
依托单位:
Negative regulatory pathways in T cell quiescence and T cell response
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批准号:8549950
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项目类别:
-
资助金额:$24.25万
-
财政年份:2012
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负责人:Hui Hu
-
依托单位:
Negative regulatory pathways in T cell quiescence and T cell response
-
批准号:8711272
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项目类别:
-
资助金额:$22.05万
-
财政年份:2012
-
负责人:Hui Hu
-
依托单位:
Transcriptional regulation of T cell quiescence and activation
-
批准号:8494552
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项目类别:
-
资助金额:$40.42万
-
财政年份:2012
-
负责人:Hui Hu
-
依托单位:
Negative regulatory pathways in T cell quiescence and T cell response
-
批准号:8420709
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项目类别:
-
资助金额:$26.0万
-
财政年份:2012
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负责人:Hui Hu
-
依托单位:
Transcriptional regulation of T cell quiescence and activation
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批准号:8297298
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项目类别:
-
资助金额:$43.5万
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财政年份:2012
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负责人:Hui Hu
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依托单位:
Transcriptional regulation of T cell activation by FOX family transcription facto
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批准号:8308715
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项目类别:
-
资助金额:$42.33万
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财政年份:2011
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负责人:Hui Hu
-
依托单位:
Essential role of transcription factor Foxp1 in B cell development and function
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批准号:7536379
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项目类别:
-
资助金额:$10.8万
-
财政年份:2008
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负责人:Hui Hu
-
依托单位:
Essential role of transcription factor Foxp1 in B cell development and function
-
批准号:7260213
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项目类别:
-
资助金额:$16.2万
-
财政年份:2008
-
负责人:Hui Hu
-
依托单位:
海外基金