Hypertensive Disorders of Pregnancy and Early Risk of Maternal CVD: Influence of the External Exposome

妊娠期高血压疾病和孕产妇心血管疾病的早期风险：外部暴露的影响

• 批准号: 10771766
• 负责人: Hui Hu
• 金额: $ 6.35万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10771766
• 关键词: Accounting; Address; Area; Aspirin; Award; Big Data; Biological Markers; Birth Records; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Clinical; Clinical Research; Data; Data Science; Data Scientist; Development; Dose; Eclampsia; Electronic Health Record; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Impact; Environmental Risk Factor; Epidemiologist; Five-Year Plans; Florida; Funding; Goals; High Risk Woman; Hypertension; Incidence; Knowledge; Leadership; Learning; Link; Measurement; Mediation; Mentorship; Modeling; Outcome; Pathogenicity; Perinatal; Perinatal Epidemiology; Play; Postpartum Period; Postpartum Women; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnant Women; Prevention; Productivity; Publications; Recording of previous events; Records; Research; Research Personnel; Research Project Grants; Residential Mobility; Risk; Risk Assessment; Risk Factors; Role; Severities; Source; Techniques; Testing; Training; Training Programs; Vital Statistics; Woman; Work; biomedical informatics; cardiovascular disorder risk; cardiovascular health; career; career development; data resource; deep learning model; design; digital repositories; experience; fetal; health data; individualized prevention; infant morbidity/mortality; informal learning; insight; maternal morbidity; maternal risk; modifiable risk; mortality; novel; post pregnancy; predictive modeling; pregnancy disorder; pregnancy hypertension; prevent; programs; skills; sociodemographics

PROJECT SUMMARY Hypertensive disorders of pregnancy (HDP) are the most common pregnancy complication and are associated with an increased long-term risk of cardiovascular disease (CVD) which is also the leading cause of death for women in the US. Emerging evidence suggests that environmental exposure during pregnancy may play an important role in the development of HDP. However, several limitations exist, including 1) the ignorance of residential mobility during pregnancy in exposure assessments, 2) the lack of studies considering different subtype, onset, and severity of HDP, and 3) the lack of considerations of the totality of environment (i.e. the exposome). While HDP have been linked to long-term CVD risk after pregnancy, limited data are available on early maternal CVD risk (within the first five years after delivery) complicated by HDP. More importantly, no study has focused on the impact of environmental exposures during and after pregnancy on maternal CVD risk after pregnancy. In addition, risk assessment models of HDP predominantly rely on biomarkers that are not ubiquitously tested among all pregnant women, and no predictive model has been developed to identify women at higher CVD risk after pregnancy. This study builds on our prior work in the external exposome and leverages our access to the unique statewide linked electronic health records-birth records data from the OneFlorida Clinical Research Consortium to address multiple challenges in the field by: 1) determining the association between pregnancy external exposome and risk of HDP, considering the subtype, onset, and severity of HDP and accounting for pregnancy residential mobility in exposure measurements; 2) assessing early risk of maternal CVD after pregnancy associated with HDP and the external exposome, and 3) developing predictive models of HDP and early risk of maternal CVD after pregnancy. This research project will be embedded in a comprehensive training program consisting of coursework, guided experiential and clinical learning, seminars, and mentorship by an established team of experts. The training program is designed to further my strengths and to develop new research skills while contributing to our scientific understanding of environmental impacts on cardiovascular health among pregnant and postpartum women. The training proposal details a five-year plan of formal and informal instruction in cardiovascular health, omics and exposome research, biomedical informatics and data science, and professional skills. My short-term career goals include completing coursework in all training areas, disseminating study findings through publications and presentations, engaging in career development activities, and applying for independent R01 funding in the third year of the award. My long-term career goal is to become an independent, collaborative, and productive epidemiologist and health data scientist leading research programs in cardiovascular health, with a focus on its intersection with perinatal and environmental epidemiology using big data.

项目总结

项目成果

Estimation of life's essential 8 score with incomplete data of individual metrics.

• DOI: 10.3389/fcvm.2023.1216693
• 发表时间: 2023
• 期刊: FRONTIERS IN CARDIOVASCULAR MEDICINE
• 影响因子: 3.6
• 作者: Zheng, Yi;Huang, Tianyi;Guasch-Ferre, Marta;Hart, Jaime;Laden, Francine;Chavarro, Jorge;Rimm, Eric;Coull, Brent;Hu, Hui
• 通讯作者: Hu, Hui

PM2.5 Constituents and Onset of Gestational Diabetes Mellitus: Identifying Susceptible Exposure Windows.

• DOI: 10.1016/j.atmosenv.2022.119409
• 发表时间: 2022-09
• 期刊: Atmospheric environment
• 影响因子: 5
• 作者: Yi Zheng;Jiang Bian;J. Hart;F. Laden;Tony Wen;Jinying Zhao;Huaizhen Qin;Hui Hu

The Science of Precision Prevention: Research Opportunities and Clinical Applications to Reduce Cardiovascular Health Disparities.

精准预防科学：减少心血管健康差异的研究机会和临床应用。

• DOI: 10.1016/j.jacadv.2023.100759
• 发表时间: 2024
• 期刊: JACC. Advances
• 作者: Pearson,ThomasA;Vitalis,Debbie;Pratt,Charlotte;Campo,Rebecca;Armoundas,AntonisA;Au,David;Beech,Bettina;Brazhnik,Olga;Chute,ChristopherG;Davidson,KarinaW;Diez-Roux,AnaV;Fine,LawrenceJ;Gabriel,Davera;Groenveld,Peter;Hall,J
• 通讯作者: Hall,J