Admin-Core-001

行政核心的总体目标是为所有人提供领导和一般行政服务。 “肺癌病因和风险综合分析”项目的各个方面。这一核心将是 负责将科学学科和研究地点纳入统一的跨学科方法。 这种方法的重点是与大规模的合作努力，系统地评估 吸烟行为与肺癌病因学、大规模遗传变异研究及其对肺癌的影响 风险，以及开发和评估告知肺癌发展风险的生物标志物。实现 我们的目标，我们的科学议程包括一系列的三个相互关联的计划项目。我们的团队的 研究人员是多学科的，建立在我们的互补优势。该核心将负责 管理所有项目和核心资源，并将确保遵守所有政府和具体的NIH 条例和要求，包括及时与项目办事处和其他 NCI员工核心将召开所有必要会议，包括内部指导委员会每月会议 委员会和外部科学咨询委员会年度会议。此外，每月的网络研讨会将 组织起来，汇集具有本建议所依据的各个学科专门知识的发言者， 沉着冷静 本核心的具体目标是：具体目标1。维持和进一步发展数据库， 流行病学和遗传学数据。这一目标有助于建立一个统一的流行病学数据大型数据库， 还为匹配遗传信息的分发提供支持。 目标2.为项目活动提供综合支持。该核心的主要功能是 确保计划项目关系和沟通的有效运作。目标3.确保 计划项目符合所有监管要求。行政核心支持 制定支持研究的方案。它还协调与dbGAP和其他 需要或请求数据传输的实体。它还将管理与NCI的所有通信 方案、技术和行政人员。目标4。提供财政监督和管理。的 行政核心监督财务管理，确保及时管理财务关系 在项目和核心之间。

The overall goal of the Administrative Core is to provide leadership and general administration related to all aspects of the program project ‘Integrative Analysis of Lung Cancer Etiology and Risk’. This Core will be responsible for integrating the scientific disciplines and study sites into a unified interdisciplinary approach. This approach is focused on working with large-scale collaborative efforts that are systematically evaluating smoking behaviors and lung cancer etiology, large-scale studies of genetic variation and impact on lung cancer risk, and development and evaluation of biomarkers that inform risk for lung cancer development. To achieve our goals, our scientific agenda comprises a series of three inter-related program projects. Our team of investigators is multidisciplinary, building upon our complementary strengths. This Core will be responsible for managing all project and core resources and will ensure compliance with all governmental and specific NIH regulations and requirements, including timely communication and consultation with project offices and other NCI staff. The core will convene all necessary meetings, including monthly meetings of the internal steering committee and annual meeting of the external scientific advisory committee. In addition, monthly webinars will be organized to bring together speakers with expertise in the various disciplines upon which this proposal is composed. The specific aims of this Core are: Specific Aim 1. Maintain and further develop a database for epidemiological and genetic data. This aim supports a large database of harmonized epidemiological data and also provides support for distribution of matching genetic information. Aim 2. Perform Integrative Support for Program Project Activities. The primary function of this core is to ensure the efficient functioning of Program Project relationships and communication. Aim 3. Ensure compliance of the Program Project with all Regulatory Requirements. The administrative core supports the development of protocols that support studies. It also coordinates relationships with dbGAP and other entities for whom data transfers are required or requested. It will also manage all communications with NCI programmatic, technical and administrative staff. Aim 4. Provide fiscal oversight and management. The administrative core oversees financial management and ensures timely management of financial relationships among the Projects and Cores.