Neuregulin in the development of hippocampal neurons

神经调节蛋白在海马神经元发育中的作用

• 批准号: 7594606
• 负责人: Zheng Li
• 金额: $ 58.95万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7594606
• 关键词: Chromosome Pairing; Cognitive; Defect; Development; Disease; Environment; Gene Mutation; Genes; Genome; Growth; Hippocampus (Brain); Knowledge; Laboratories; Laws; Mental Depression; Mental disorders; Morphogenesis; Neuregulins; Neurons; Process; Protein Isoforms; Protein Overexpression; Risk; Schizophrenia; Synapses; Synaptic Transmission; experience; gene function; neural circuit; programs

We are investigating the subcellular localization and effect of overexpressing neuregulin in hippocampal neurons. We observed that neuregulin exists in clusters in hippocampal neurons. We are examining whether these neuregulin clusters associate with specific subcellular compartments. We are also analyzing the effect of overexpressing neuregulin on the morphogenesis of hippocampal neurons. In addition, we are building expressing constructs for different isoforms of neuregulins, and will compare the difference between their subcellular localization and effect on hippocampal neuron development.

我们正在研究神经调节蛋白在海马神经元中的亚细胞定位和过度表达的影响。我们观察到神经调节蛋白在海马神经元中呈簇状分布。我们正在研究这些神经调节素簇是否与特定的亚细胞隔间有关。我们还分析了神经调节蛋白的过度表达对海马神经元形态发生的影响。此外，我们正在为不同亚型的神经调节蛋白构建表达载体，并将比较它们在亚细胞定位和对海马神经元发育的影响之间的差异。