Neuregulin in the development of hippocampal neurons
Neuregulin in the development of hippocampal neurons
批准号:
7594606
负责人:
Zheng Li
金额:
$58.95万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Chromosome PairingCognitiveDefectDevelopmentDiseaseEnvironmentGene MutationGenesGenomeGrowthHippocampus (Brain)KnowledgeLaboratoriesLawsMental DepressionMental disordersMorphogenesisNeuregulinsNeuronsProcessProtein IsoformsProtein OverexpressionRiskSchizophreniaSynapsesSynaptic Transmissionexperiencegene functionneural circuitprograms
中文摘要
我们正在研究神经调节蛋白在海马神经元中的亚细胞定位和过度表达的影响。我们观察到神经调节蛋白在海马神经元中呈簇状分布。我们正在研究这些神经调节素簇是否与特定的亚细胞隔间有关。我们还分析了神经调节蛋白的过度表达对海马神经元形态发生的影响。此外,我们正在为不同亚型的神经调节蛋白构建表达载体,并将比较它们在亚细胞定位和对海马神经元发育的影响之间的差异。
英文摘要
We are investigating the subcellular localization and effect of overexpressing neuregulin in hippocampal neurons. We observed that neuregulin exists in clusters in hippocampal neurons. We are examining whether these neuregulin clusters associate with specific subcellular compartments. We are also analyzing the effect of overexpressing neuregulin on the morphogenesis of hippocampal neurons. In addition, we are building expressing constructs for different isoforms of neuregulins, and will compare the difference between their subcellular localization and effect on hippocampal neuron development.
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