Understanding and Addressing Cancer Health Disparities in Louisiana

了解并解决路易斯安那州的癌症健康差异

• 批准号: 9788353
• 负责人: Lucio Miele
• 金额: $ 94.68万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-19 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9788353
• 关键词: Address; Affect; African American; Area; Biological; Biological Factors; Biology; Breast Cancer Patient; Cancer Biology; Cancer Center; Cancer Center Planning Grant; Cancer Etiology; Characteristics; Chemotherapy-Oncologic Procedure; Clinical; Clinical Trials; Comorbidity; Complex; Data; Diagnosis; Disease; Disease Outcome; Elements; Endometrial; Endometrial Carcinoma; Ensure; Environmental Risk Factor; Epidemiology; Future; Genetic; Genomics; Goals; Grant; Immune; Immunity; Immunologics; Immunology; Immunotherapy; Impairment; In complete remission; Incidence; Inequality; Infiltration; Inflammation; Inflammatory; Infrastructure; Institution; Intervention; Investigation; Leadership; Light; Literature; Liver; Louisiana; Malignant Neoplasms; Malignant neoplasm of prostate; Measurable; Medical; Metabolic; Metabolism; Minority; Mutation; Myeloid-derived suppressor cells; Neoadjuvant Therapy; Not Hispanic or Latino; Obesity; Outcome; Pathologic; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Politics; Population; Portraits; Prevention; Preventive Intervention; Primary carcinoma of the liver cells; Prognostic Marker; Public Health; Renal Cell Carcinoma; Renal carcinoma; Research; Research Personnel; Research Project Grants; Research Support; Role; Socioeconomic Factors; Stress; Survival Rate; T cell response; Testing; Therapeutic Intervention; Transcript; Treatment Efficacy; Tumor Biology; Tumor Immunity; Tumor-infiltrating immune cells; Underserved Population; Woman; Work; cancer health disparity; cancer therapy; chemotherapy; economic determinant; fatty acid oxidation; genomic signature; gulf coast; health care availability; health disparity; improved; improved outcome; inhibitor/antagonist; insight; malignant breast neoplasm; molecular subtypes; mortality; novel; novel diagnostics; novel strategies; novel therapeutic intervention; novel therapeutics; nutrition; patient population; resistance mechanism; response; social health determinants; socioeconomics; success; tool; triple-negative invasive breast carcinoma; tumor

ABSTRACT: Cancer health disparities represent a major public health crisis in the state of Louisiana and the Gulf Coast. The citizens of this region have to contend with cancer incidence and mortality rates that are among the highest in the nation. In addition, we have a very high incidence of specific malignancies that disproportionately affect minorities and the underserved citizens of the region. Triple negative breast cancer, hepatocellular carcinoma, endometrial cancer, advanced prostate cancer, renal cell carcinoma, among others, are more common and appear to be more aggressive among minorities. Complex socio-economic and political reasons and an increase in co-morbidities, such as obesity, may in part help explain the origin of some of these health disparities. However, increasing evidence from genomics and cancer biology, including our work, has started to shed light on the biological basis for some of these inequities, and suggests specific interventions to help ameliorate the impact of these diseases and improve patient outcomes. We plan to use this P20 planning grant to establish research projects that bring together the best investigators and institutions in Louisiana who are conducting research on the genetics/genomics, immunology, and clinical and public health aspects of cancer with special emphasis on health disparities. Under the leadership of the LSU Stanley S. Scott Cancer Center in New Orleans (LSU-CC-NO) and in partnership with investigators from academic and medical institutions in the state, we have agreed to conduct research under the new Gulf South Center for Research and Solutions in Cancer Health Disparities (Gulf South-CARES-CHD). To ensure a focused and productive effort, this P20 grant we will study the genomic signature and inflammation characteristics of triple negative breast cancer (TNBC), a disease that disproportionately affects young African-American women in Louisiana. We believe that understanding the genomics and inflammatory biology of specific cancers may provide insights into mechanisms of resistance to neoadjuvant chemotherapy and help identify and test potential interventions for improving the therapeutic efficacy of current and future treatments. Besides creating competitive teams of researchers, we will build the necessary intellectual and organizational infrastructure and develop the preliminary data to plan and support research projects that qualify for a SPORE application. Our combined expertise, the unique patient populations available in Louisiana, and the commitment of our institutions will enable us to achieve these goals, which will improve prevention, diagnosis and treatment of cancer in underserved populations, both in Louisiana and globally.

摘要： 癌症健康差异是路易斯安那州和墨西哥湾沿岸的一个重大公共卫生危机。 该地区的公民不得不与癌症发病率和死亡率作斗争， 全国最高。此外，我们有一个非常高的发病率的特定恶性肿瘤， 这对该区域少数群体和得不到充分服务的公民造成了不成比例的影响。三阴性乳腺癌， 肝细胞癌、子宫内膜癌、晚期前列腺癌、肾细胞癌， 另一些人则更为常见，在少数群体中似乎更具侵略性。复杂的社会经济 政治原因和并发症的增加，如肥胖，可能部分有助于解释 这些健康方面的差异。然而，越来越多的来自基因组学和癌症生物学的证据，包括 我们的工作，已经开始阐明这些不平等的生物学基础，并提出了具体的建议。 干预措施，以帮助减轻这些疾病的影响，并改善患者的结果。我们计划使用 这个P20规划补助金，以建立研究项目，汇集最好的研究人员， 路易斯安那州的研究机构正在进行遗传学/基因组学，免疫学和临床研究。 和癌症的公共卫生方面，特别强调健康差距。领导下 LSU Stanley S.斯科特癌症中心在新奥尔良（LSU-CC-NO），并与来自 在该州的学术和医疗机构，我们已经同意在新的海湾进行研究， 南部癌症健康差异研究和解决方案中心（海湾南部-CARES-CHD）。确保 一个集中和富有成效的努力，这个P20赠款，我们将研究基因组签名和炎症 三阴性乳腺癌（TNBC）的特征，这种疾病不成比例地影响年轻人 路易斯安那州的非裔美国女性我们相信，了解基因组学和炎症 特定癌症的生物学可能提供对新辅助化疗耐药机制的见解 并帮助识别和测试潜在的干预措施，以提高当前和未来的治疗效果。 治疗。除了建立有竞争力的研究团队，我们还将建立必要的智力和 组织基础设施和开发初步数据，以规划和支持研究项目， 有资格申请SPORE。我们的综合专业知识，独特的患者群体， 路易斯安那州，以及我们机构的承诺将使我们能够实现这些目标，这将改善 在路易斯安那州和全球服务不足的人群中预防、诊断和治疗癌症。