Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury (CAPCOG-TBI)
脑外伤后的大脑自动调节、脑灌注和神经认知结果 (CAPCOG-TBI)
基本信息
- 批准号:10733565
- 负责人:
- 金额:$ 83.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2028-05-31
- 项目状态:未结题
- 来源:
- 关键词:AccountingAcuteAddressAdultAffectAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAttentionAxonBilateralBlood Flow VelocityBlood PressureBlood VesselsBrainBrain InjuriesBrain imagingBrain regionCephalicCerebrovascular CirculationCerebrovascular DisordersCerebrovascular PhysiologyCerebrumChronicClinicalCognitionCognitiveDataDementiaDevelopmentDiseaseElderlyEpisodic memoryEtiologyFingersGoalsHealthHomeostasisImpaired cognitionImpairmentIndividualInjuryInternal carotid artery structureKnowledgeLiquid substanceLongitudinal StudiesMagnetic Resonance ImagingMeasuresMediatingMemory impairmentNear-Infrared SpectroscopyNerve DegenerationNeurobehavioral ManifestationsNeurocognitiveNonpharmacologic TherapyOrthopedicsOutcomePerfusionPhotoplethysmographyPopulationQuality of lifeRecoveryRecovery of FunctionResearchResearch PrioritySeveritiesStructureSumSurvivorsTimeTraumaTraumatic Brain InjuryTraumatic Brain Injury recoveryUltrasonographyUnited States National Institutes of Healthaxon injurybrain tissuebrain volumecerebrovascularclinical carecognitive performancecognitive recoverycrosslinkdiagnostic strategydisabilityeconomic costepidemiology studyexperiencefunctional outcomeshemodynamicshypoperfusionimaging approachimaging biomarkerimprovedindividual variationinjury recoverymultimodalityneuroimagingnoninvasive diagnosispharmacologicprimary outcomeprocessing speedsexsymposiumtargeted treatmenttissue oxygenationvascular contributionsvertebral arterywhite matter
项目摘要
PROJECT SUMMARY
Traumatic brain injury (TBI) is a leading cause of disability in adults and the quality of life of TBI survivors is
highly dependent on the adequacy of cognitive recovery. TBI is also a risk factor for Alzheimer’s disease (AD)
and AD-related dementias (ADRD). Mounting evidence indicates that cerebrovascular dysfunction occurs in
both TBI and AD/ADRD and can be a cross-link between the two diseases. The 2019 ADRD Summit called for
further studies to understand vascular contributions to progressive cognitive impairment/dementia associated
with TBI and develop non-invasive diagnostic approaches5,9. The following important knowledge gaps exist:
1) What is the impact of early cerebrovascular dysfunction after TBI on short and long-term cognitive outcomes
after accounting for age, sex, and pre-existing health conditions? 2) What is the temporal relationship between
the cerebrovascular function recovery and cognitive outcome after TBI? and 3) Is there a relationship between
cerebrovascular dysfunction and post-TBI neurodegeneration? The overarching goal of this proposal is to
determine whether acute cerebrovascular dysfunction and its recovery within the first year postinjury are
associated with cognitive outcomes and neurodegeneration 12 months after moderate to severe TBI (msTBI).
Our central hypothesis is that cerebrovascular function measured by dynamic cerebral autoregulation (CA)
and brain perfusion during acute stage and its recovery during the first year are inversely associated with
cognitive outcomes and brain volume loss at 12 months postinjury. We propose a longitudinal study with 100
adults who sustained a single msTBI and 30 controls with non-TBI orthopedic trauma in the first week after the
initial injury. We will follow them at 3 months, 6 months, and 12 months after injury. The primary outcome will
be the NIH Toolbox Cognitive battery fluid composite score supplemented with sensitive episodic memory and
processing speed measures at 12 months postinjury. To address the overarching goal, we aim to 1) determine
the association of cerebrovascular dysfunction during the acute stage of msTBI (<1-week postinjury) with
cognitive outcome at 1 year. CA will be quantified by dynamic changes in arterial blood pressure and cerebral
blood flow velocity or brain tissue oxygenation. Brain perfusion will be determined by the sum of cerebral blood
flow measured from the bilateral internal carotid artery and vertebral artery. 2) To determine the temporal
association between the recovery of cerebrovascular function and cognitive outcomes after TBI. CA and brain
perfusion will be measured at 3, 6 and 12 months postinjury. 3) To determine the temporal associations of
acute cerebrovascular dysfunction and its recovery with the imaging biomarkers of neurodegeneration after
TBI over time. Multimodal MRI studies will be performed at 3 months and 12 months postinjury. The findings
from this study will improve our understanding of cerebrovascular contributions to cognitive outcome and
neurodegeneration after TBI. The knowledge obtained will provide critical data to inform the development of
strategies based on vascular mechanisms to improve cognition and slow neurodegeneration after TBI.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
KAN DING其他文献
KAN DING的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('KAN DING', 18)}}的其他基金
ELECTRO-BOOST: Electroencephalography for cerebral trauma recovery and oxygenation
ELECTRO-BOOST:用于脑外伤恢复和氧合的脑电图
- 批准号:
10468743 - 财政年份:2020
- 资助金额:
$ 83.97万 - 项目类别:
ELECTRO-BOOST: Electroencephalography for cerebral trauma recovery and oxygenation
ELECTRO-BOOST:用于脑外伤恢复和氧合的脑电图
- 批准号:
10227094 - 财政年份:2020
- 资助金额:
$ 83.97万 - 项目类别:
ELECTRO-BOOST: Electroencephalography for cerebral trauma recovery and oxygenation
ELECTRO-BOOST:用于脑外伤恢复和氧合的脑电图
- 批准号:
10033586 - 财政年份:2020
- 资助金额:
$ 83.97万 - 项目类别:
相似海外基金
Transcriptional assessment of haematopoietic differentiation to risk-stratify acute lymphoblastic leukaemia
造血分化的转录评估对急性淋巴细胞白血病的风险分层
- 批准号:
MR/Y009568/1 - 财政年份:2024
- 资助金额:
$ 83.97万 - 项目类别:
Fellowship
Combining two unique AI platforms for the discovery of novel genetic therapeutic targets & preclinical validation of synthetic biomolecules to treat Acute myeloid leukaemia (AML).
结合两个独特的人工智能平台来发现新的基因治疗靶点
- 批准号:
10090332 - 财政年份:2024
- 资助金额:
$ 83.97万 - 项目类别:
Collaborative R&D
Acute senescence: a novel host defence counteracting typhoidal Salmonella
急性衰老:对抗伤寒沙门氏菌的新型宿主防御
- 批准号:
MR/X02329X/1 - 财政年份:2024
- 资助金额:
$ 83.97万 - 项目类别:
Fellowship
Cellular Neuroinflammation in Acute Brain Injury
急性脑损伤中的细胞神经炎症
- 批准号:
MR/X021882/1 - 财政年份:2024
- 资助金额:
$ 83.97万 - 项目类别:
Research Grant
STTR Phase I: Non-invasive focused ultrasound treatment to modulate the immune system for acute and chronic kidney rejection
STTR 第一期:非侵入性聚焦超声治疗调节免疫系统以治疗急性和慢性肾排斥
- 批准号:
2312694 - 财政年份:2024
- 资助金额:
$ 83.97万 - 项目类别:
Standard Grant
Combining Mechanistic Modelling with Machine Learning for Diagnosis of Acute Respiratory Distress Syndrome
机械建模与机器学习相结合诊断急性呼吸窘迫综合征
- 批准号:
EP/Y003527/1 - 财政年份:2024
- 资助金额:
$ 83.97万 - 项目类别:
Research Grant
FITEAML: Functional Interrogation of Transposable Elements in Acute Myeloid Leukaemia
FITEAML:急性髓系白血病转座元件的功能研究
- 批准号:
EP/Y030338/1 - 财政年份:2024
- 资助金额:
$ 83.97万 - 项目类别:
Research Grant
KAT2A PROTACs targetting the differentiation of blasts and leukemic stem cells for the treatment of Acute Myeloid Leukaemia
KAT2A PROTAC 靶向原始细胞和白血病干细胞的分化,用于治疗急性髓系白血病
- 批准号:
MR/X029557/1 - 财政年份:2024
- 资助金额:
$ 83.97万 - 项目类别:
Research Grant
ロボット支援肝切除術は真に低侵襲なのか?acute phaseに着目して
机器人辅助肝切除术真的是微创吗?
- 批准号:
24K19395 - 财政年份:2024
- 资助金额:
$ 83.97万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Acute human gingivitis systems biology
人类急性牙龈炎系统生物学
- 批准号:
484000 - 财政年份:2023
- 资助金额:
$ 83.97万 - 项目类别:
Operating Grants