Developing an in vivo infectious disease training program at the University of Cape Town

开普敦大学开发体内传染病培训项目

• 批准号: 10731772
• 负责人: William Horsnell
• 金额: $ 10.98万
• 依托单位: UNIVERSITY OF CAPE TOWN
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-20 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10731772
• 关键词: Acceleration; Africa South of the Sahara; Animal Model; Antimicrobial Resistance; Bacterial Infections; Biology; California; Clinical Research; Communicable Diseases; Complement; Development; Disease; Disease model; Ethics; Exclusion; Grant; Home; Human; Immunity; Infection; Infectious Diseases Research; International; Klebsiella pneumoniae; Mus; Mycobacterium tuberculosis; Pathogenesis; Primates; Process; Public Health; Reagent; Research; Research Personnel; Research Training; Resources; Salmonella enterica; South Africa; Streptococcus pneumoniae; Training; Training Programs; Universities; Vaccines; Veterinary Schools; Virulence; Work; animal facility; biological research; in vivo; infectious disease model; mortality; pathogen; pathogenic bacteria; pre-doctoral; prevent; programs; symposium

PROJECT SUMMARY This application seeks to plan and develop a research training program at the University of Cape town (UCT) that will focus on understanding basic mechanisms underlying bacterial disease in sub-Saharan Africa (SSA). Bacterial infectious diseases (excluding mTB) are a huge public health problem in SSA as infections caused by bacterial pathogens, such as Salmonella enterica and Streptococcus pneumonia, are major causes of mortality. The impact of these pathogens is compounded by widespread antimicrobial resistance (AMR), vaccines against these pathogens developed outside of SSA being less effective at preventing serious illness and increasing pathogen virulence. Combined these limit treatment options of these recognized pathogens and promote emergence of new bacterial causes of mortality (e.g. Klebsiella pneumonia). While microbiological and clinical research groups in South Africa contribute significantly to global understanding of these diseases, these groups do not significantly complement this work with complementary mechanistic in vivo studies. Thus, an urgent need exists to develop advanced regional training in undertaking such in vivo research into bacterial pathogenesis and host immunity. The objective of our proposed training program is to fill this gap by leveraging existing strengths and unique resources both at UCT and at our overseas partners at the University of California Davis (UCD) to develop a research training program. UCT is home to a world class animal facility that is underutilized by researchers studying non-mTB bacterial infections. UCD has unique resources that support animal modelling including the #1 ranked Veterinary School globally, the California National Primate Research Center, the internationally renowned Mouse Biology Program, and a T32 supported predoctoral program focussed on Animal models of Infectious Diseases. Thus unique expertise exists at UCD that will be invaluable in supporting the UCT program. We propose a 2-year planning process that will develop an advanced training platform in in vivo studies of non-mTB bacterial infection in SSA which we will submit as a competitive proposal for a D43 Global Infectious Disease Research Training program. Project leaders at UCT and UCD have already identified existing overlapping research strengths that will benefit from in vivo disease modelling at UCT. D71 supported symposia and researcher exchanges between UCT and UCD will support the key interactions enabling realization of a competitive and deliverable D43 program. The planning of this program will also require implementation of ethically approved SOPs, acquisition of permits to allow transfer of state-of-the-art research reagents to UCT, as well as development of a new research training program for junior investigators and fellows. The final submission of a competitive D43 program grant will present a program that will enable high impact mechanistic bacterial infection biology studies at UCT. The research that emanates from this will accelerate regional and global control of devastating human bacterial infectious diseases.

项目总结 本申请旨在规划和开发开普敦大学(UCT)的研究培训计划。 这将侧重于了解撒哈拉以南非洲(SSA)细菌疾病的基本机制。 细菌性传染病(不包括结核分枝杆菌)是SSA一个巨大的公共卫生问题，因为感染是由 由肠道沙门氏菌和肺炎链球菌等细菌病原体引起的 死亡率。广泛的抗菌素耐药性(AMR)加剧了这些病原体的影响， 在SSA之外开发的针对这些病原体的疫苗在预防严重疾病方面效果较差 以及提高病原菌的致病力。将这些已知病原体的这些限制治疗方案结合起来 并促进新的致死细菌的出现(例如肺炎克雷伯氏菌)。而当 南非的微生物学和临床研究小组对全球了解做出了重大贡献 在这些疾病中，这些群体并没有以互补的机制显著地补充这项工作 活体研究。因此，迫切需要在体内开展这种高级区域培训 细菌致病机制和宿主免疫的研究。我们建议的培训计划的目标是 通过利用UCT和我们的海外合作伙伴的现有优势和独特资源来填补这一空白 在加州大学戴维斯分校(UCD)开发一个研究培训计划。密歇根大学是一个世界的家园 研究非结核分枝杆菌细菌感染的研究人员未充分利用的一类动物设施。UCD有 支持动物建模的独特资源，包括全球排名第一的兽医学校， 加州国家灵长类动物研究中心，国际知名的老鼠生物学计划，以及一个 T32支持的博士前项目，重点是传染病的动物模型。因此独一无二 UCD拥有的专业知识将对支持UCT计划起到无价的作用。我们提出了一个为期两年的规划 这一进程将在非结核分枝杆菌感染的体内研究中开发高级培训平台 SSA，我们将作为D43全球传染病研究培训的竞争性提案提交 程序。UCT和UCD的项目负责人已经确定了现有的重叠研究优势 这将受益于UCT的活体疾病建模。D71支持的研讨会和研究人员交流 UCT和UCD之间将支持关键互动，从而实现具有竞争力和可交付成果 D43程序。该计划的规划还将要求执行经道德批准的SOP， 获得许可，允许将最先进的研究试剂转让给联合技术大学，以及进行开发 一项针对初级调查人员和研究员的新研究培训计划。最终提交的一份竞争性的 D43计划拨款将提出一项计划，该计划将使高影响力的机械细菌感染生物学 在科罗拉多大学学习。由此产生的研究将加速区域和全球对 毁灭性的人类细菌性传染病。