Developing an in vivo infectious disease training program at the University of Cape Town

开普敦大学开发体内传染病培训项目

• 批准号: 10731772
• 负责人: William Horsnell
• 金额: $ 10.98万
• 依托单位: UNIVERSITY OF CAPE TOWN
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-20 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10731772
• 关键词: Acceleration; Africa South of the Sahara; Animal Model; Antimicrobial Resistance; Bacterial Infections; Biology; California; Clinical Research; Communicable Diseases; Complement; Development; Disease; Disease model; Ethics; Exclusion; Grant; Home; Human; Immunity; Infection; Infectious Diseases Research; International; Klebsiella pneumoniae; Mus; Mycobacterium tuberculosis; Pathogenesis; Primates; Process; Public Health; Reagent; Research; Research Personnel; Research Training; Resources; Salmonella enterica; South Africa; Streptococcus pneumoniae; Training; Training Programs; Universities; Vaccines; Veterinary Schools; Virulence; Work; animal facility; biological research; in vivo; infectious disease model; mortality; pathogen; pathogenic bacteria; pre-doctoral; prevent; programs; symposium

PROJECT SUMMARY This application seeks to plan and develop a research training program at the University of Cape town (UCT) that will focus on understanding basic mechanisms underlying bacterial disease in sub-Saharan Africa (SSA). Bacterial infectious diseases (excluding mTB) are a huge public health problem in SSA as infections caused by bacterial pathogens, such as Salmonella enterica and Streptococcus pneumonia, are major causes of mortality. The impact of these pathogens is compounded by widespread antimicrobial resistance (AMR), vaccines against these pathogens developed outside of SSA being less effective at preventing serious illness and increasing pathogen virulence. Combined these limit treatment options of these recognized pathogens and promote emergence of new bacterial causes of mortality (e.g. Klebsiella pneumonia). While microbiological and clinical research groups in South Africa contribute significantly to global understanding of these diseases, these groups do not significantly complement this work with complementary mechanistic in vivo studies. Thus, an urgent need exists to develop advanced regional training in undertaking such in vivo research into bacterial pathogenesis and host immunity. The objective of our proposed training program is to fill this gap by leveraging existing strengths and unique resources both at UCT and at our overseas partners at the University of California Davis (UCD) to develop a research training program. UCT is home to a world class animal facility that is underutilized by researchers studying non-mTB bacterial infections. UCD has unique resources that support animal modelling including the #1 ranked Veterinary School globally, the California National Primate Research Center, the internationally renowned Mouse Biology Program, and a T32 supported predoctoral program focussed on Animal models of Infectious Diseases. Thus unique expertise exists at UCD that will be invaluable in supporting the UCT program. We propose a 2-year planning process that will develop an advanced training platform in in vivo studies of non-mTB bacterial infection in SSA which we will submit as a competitive proposal for a D43 Global Infectious Disease Research Training program. Project leaders at UCT and UCD have already identified existing overlapping research strengths that will benefit from in vivo disease modelling at UCT. D71 supported symposia and researcher exchanges between UCT and UCD will support the key interactions enabling realization of a competitive and deliverable D43 program. The planning of this program will also require implementation of ethically approved SOPs, acquisition of permits to allow transfer of state-of-the-art research reagents to UCT, as well as development of a new research training program for junior investigators and fellows. The final submission of a competitive D43 program grant will present a program that will enable high impact mechanistic bacterial infection biology studies at UCT. The research that emanates from this will accelerate regional and global control of devastating human bacterial infectious diseases.

项目摘要 本申请旨在规划和发展一个研究培训计划在大学的开普敦（UCT） 这将侧重于了解撒哈拉以南非洲（SSA）细菌性疾病的基本机制。 细菌性传染病（不包括mTB）是SSA的一个巨大的公共卫生问题， 由细菌病原体，如沙门氏菌和肺炎链球菌，是主要的原因， mortality.这些病原体的影响因广泛的抗菌素耐药性（AMR）而加剧， 在撒哈拉以南非洲以外开发的针对这些病原体的疫苗在预防严重疾病方面效果较差 并增加病原体的毒力。结合这些已知病原体的这些限制治疗选择 并促进新的细菌性死亡原因的出现（例如肺炎克雷伯氏菌）。而 南非的微生物和临床研究小组为全球了解做出了重大贡献 在这些疾病中，这些群体并没有用互补的机制来显著地补充这项工作。 体内研究。因此，迫切需要发展先进的区域培训， 研究细菌致病机理和宿主免疫。我们提出的培训计划的目标是 通过利用UCT和海外合作伙伴的现有优势和独特资源来填补这一空白 在加州戴维斯大学（UCD）开发一个研究培训计划。UCT是一个世界的家园 这类动物设施未被研究非mTB细菌感染的研究人员充分利用。UCD已经 支持动物建模的独特资源，包括全球排名第一的兽医学院， 加州国家灵长类动物研究中心、国际知名的小鼠生物学计划以及一个 T32支持的博士前计划专注于传染病的动物模型。如此独特 专业知识存在于UCD，这将是在支持UCT计划的宝贵。我们提出一个两年规划 该过程将开发一个先进的培训平台，在体内研究非mTB细菌感染， 我们将提交SSA作为D43全球传染病研究培训的竞争性提案 程序. UCT和UCD的项目负责人已经确定了现有的重叠研究优势 这将受益于UCT的体内疾病建模。D71支持的专题讨论会和研究人员交流 UCT和UCD之间的合作将支持关键的互动，从而实现竞争和交付 D43程序。该项目的规划还需要执行经伦理批准的标准操作规程， 获得许可证，允许将最先进的研究试剂转移到UCT，以及开发 为初级研究员和研究员提供新的研究培训计划。最后提交的竞争性 D43计划拨款将提出一个计划，使高影响力的机械细菌感染生物学 在UCT学习由此产生的研究将加速区域和全球对 毁灭性的人类细菌传染病。