Admin Core

项目概要/摘要 本申请的总体目标是建立和表征大量少数患者来源的 来自两种癌症类型（胃癌和肺癌）的癌症异种移植物（PDX），并利用这些PDX引导癌症 精准医疗决策，重点关注种族/少数民族人群。我们建立了大学 加州和UT西南多样性PDX和试验开发中心（UCaTS），建立在一个 现有的癌症健康差距研究网络，包括六个国家癌症研究所指定的综合癌症 中心：加州大学戴维斯分校，加州大学欧文分校健康Chao家庭综合癌症中心（加州大学欧文分校），加州大学洛杉矶 Jonsson综合癌症中心（UCLA），加州大学圣地亚哥分校Moores癌症中心，加州大学旧金山分校弗朗西斯科 海伦迪勒家庭综合癌症中心（UCSF）和得克萨斯大学西南哈罗德C。 西蒙斯癌症中心（UTSW）。行政核心的作用是协调研究工作， 不同的校园，并最大限度地利用资金和资源。行政核心成员 包括UCaTS联系人PI，PI对PDX进行了广泛研究，并拥有国家/国际 癌症健康差异的领导专业知识。联系PI Carvajal-Carmona博士将负责 整体方案管理。与联系PI密切合作，该核心将得到 生物统计学家、五名研究中心PI和一名UCD CRC帮助协调患者标本采集，两名研究 项目负责人和一名赠款管理员来实现UCaTS的目标。行政核心将维持 与NCI工作人员、PDXNet数据共享和协调中心（PDCCC）、患者- 弗雷德里克国家癌症研究实验室（PDMR-FNLCR）的衍生模型库，以及其他 PDX开发和试验中心（PDTC）制定标准操作规程（SOP），协调 研究活动，交叉验证PDX研究，并将PDX模型存款到PDXNet中。管理核心将是 负责建立和维护中心的沟通和财务管理，以确保UCaTS 将及时实现其目标。

PROJECT SUMMARY/ABSTRACT The overall goal of this application is to establish and characterize a large collection of minority patient-derived cancer xenografts (PDXs) from two cancer types (gastric and lung) and utilize these PDXs to guide cancer precision medicine decision making focusing on racial/ethnic minority populations. We established the University of California and UT Southwestern Diversity-PDX and Trial Development Center (UCaTS) that is built on an existing cancer health disparity research network, and includes six NCI-designated Comprehensive Cancer Centers: UC Davis, UC Irvine Health Chao Family Comprehensive Cancer Center (UC Irvine), UC Los Angeles Jonsson Comprehensive Cancer Center (UCLA), UC San Diego Moores Cancer Center, UC San Francisco Helen Diller Family Comprehensive Cancer Center (UCSF) and University of Texas Southwestern Harold C. Simmons Cancer Center (UTSW). The role of the Administrative Core is to coordinate the research effort among different campuses and to maximize the use of the funding and resources. The Administrative core members include UCaTS contact PI, who has conducted extensive research in PDXs and has national/international leadership expertise in cancer health disparities. The contact PI, Dr. Carvajal-Carmona, will be responsible for the overall program administration. Working closely with the contact PI, this Core will have support from a Biostatistician, five Site PIs, and a UCD CRC to help coordinate patient specimen collection, the two Research Project leads, and a grant administrator to operationalize UCaTS goals. The Administrative Core will maintain constant contact with the NCI staff, the PDXNet Data Commons and Coordinating Center (PDCCC), Patient- Derived Models Repository at Frederick National Laboratory for Cancer Research (PDMR-FNLCR), and other PDX Development and Trials Centers (PDTCs) to develop standard operating procedures (SOPs), coordinate research activities, cross-validate PDX research, and deposit PDX models into PDXNet. The Admin Core will be responsible for establishing and maintaining Center communication and fiscal management to ensure UCaTS will deliver its objectives in a timely manner.