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Admin Core

管理核心

基本信息

批准号：
10733392
负责人：
Luis Guillermo Carvajal Carmona
金额：
$ 22.65万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10733392
关键词：
Academic Medical Centers Accountability Administrator Animals Benchmarking Bioinformatics Budgets California Cancer Center Cancer Model Cancer Patient Cancer health equity Catchment Area Certification Clinical Research Collaborations Collection Communication Complex Comprehensive Cancer Center Data Commons Decision Making Deposition Development Doctor of Philosophy Documentation Ensure Family Funding Generations Genetic Genomics Goals Grant Health Health Disparities Research Infrastructure Institution International Interruption Laboratories Leadership Los Angeles Lung Lung Neoplasms Malignant Neoplasms Malignant neoplasm of lung Maps Minority Modeling Monitor Pathway interactions Patients Pre-Clinical Model Procedures Productivity Quality Control Recommendation Research Research Activity Research Personnel Research Project Grants Resources Role San Francisco Site Specimen Stomach Stomach Neoplasms Texas Universities Work Xenograft Model Xenograft procedure anticancer research cancer health disparity cancer type data exchange data sharing ethnic diversity ethnic minority ethnic minority population expectation experimental study human subject malignant stomach neoplasm meetings member minority patient novel therapeutics patient derived xenograft model pre-clinical research precision oncology programs quality assurance racial diversity racial minority racial minority population repository sample collection success targeted treatment timeline treatment response

项目摘要

PROJECT SUMMARY/ABSTRACT The overall goal of this application is to establish and characterize a large collection of minority patient-derived cancer xenografts (PDXs) from two cancer types (gastric and lung) and utilize these PDXs to guide cancer precision medicine decision making focusing on racial/ethnic minority populations. We established the University of California and UT Southwestern Diversity-PDX and Trial Development Center (UCaTS) that is built on an existing cancer health disparity research network, and includes six NCI-designated Comprehensive Cancer Centers: UC Davis, UC Irvine Health Chao Family Comprehensive Cancer Center (UC Irvine), UC Los Angeles Jonsson Comprehensive Cancer Center (UCLA), UC San Diego Moores Cancer Center, UC San Francisco Helen Diller Family Comprehensive Cancer Center (UCSF) and University of Texas Southwestern Harold C. Simmons Cancer Center (UTSW). The role of the Administrative Core is to coordinate the research effort among different campuses and to maximize the use of the funding and resources. The Administrative core members include UCaTS contact PI, who has conducted extensive research in PDXs and has national/international leadership expertise in cancer health disparities. The contact PI, Dr. Carvajal-Carmona, will be responsible for the overall program administration. Working closely with the contact PI, this Core will have support from a Biostatistician, five Site PIs, and a UCD CRC to help coordinate patient specimen collection, the two Research Project leads, and a grant administrator to operationalize UCaTS goals. The Administrative Core will maintain constant contact with the NCI staff, the PDXNet Data Commons and Coordinating Center (PDCCC), Patient- Derived Models Repository at Frederick National Laboratory for Cancer Research (PDMR-FNLCR), and other PDX Development and Trials Centers (PDTCs) to develop standard operating procedures (SOPs), coordinate research activities, cross-validate PDX research, and deposit PDX models into PDXNet. The Admin Core will be responsible for establishing and maintaining Center communication and fiscal management to ensure UCaTS will deliver its objectives in a timely manner.

项目总结/摘要本申请的总体目标是建立和表征大量少数患者来源的来自两种癌症类型（胃癌和肺癌）的癌症异种移植物（PDX），并利用这些PDX引导癌症精准医疗决策，重点关注种族/少数民族人群。我们建立了大学加州和UT西南多样性PDX和试验开发中心（UCaTS），建立在一个现有的癌症健康差距研究网络，包括六个国家癌症研究所指定的综合癌症中心：加州大学戴维斯分校，加州大学欧文分校健康Chao家庭综合癌症中心（加州大学欧文分校），加州大学洛杉矶 Jonsson综合癌症中心（UCLA），加州大学圣地亚哥分校Moores癌症中心，加州大学旧金山分校弗朗西斯科海伦迪勒家庭综合癌症中心（UCSF）和得克萨斯大学西南哈罗德C。西蒙斯癌症中心（UTSW）。行政核心的作用是协调研究工作，不同的校园，并最大限度地利用资金和资源。行政核心成员包括UCaTS联系人PI，PI对PDX进行了广泛研究，并拥有国家/国际癌症健康差异的领导专业知识。联系PI Carvajal-Carmona博士将负责整体方案管理。与联系PI密切合作，该核心将得到生物统计学家、五名研究中心PI和一名UCD CRC帮助协调患者标本采集，两名研究项目负责人和一名赠款管理员来实现UCaTS的目标。行政核心将维持与NCI工作人员、PDXNet数据共享和协调中心（PDCCC）、患者- 弗雷德里克国家癌症研究实验室（PDMR-FNLCR）的衍生模型库，以及其他 PDX开发和试验中心（PDTC）制定标准操作规程（SOP），协调研究活动，交叉验证PDX研究，并将PDX模型存款到PDXNet中。管理核心将是负责建立和维护中心的沟通和财务管理，以确保UCaTS 将及时实现其目标。