Admin Core

项目摘要/摘要 这个应用程序总体目标是建立和描述一个由少数族裔患者衍生的大型集合 来自两种癌症类型(胃癌和肺癌)的异种癌症移植(PDX)并利用这些PDX来指导癌症 关注种族/少数民族人群的精准医疗决策。我们成立了这所大学 加州和德克萨斯大学西南分集-PDX和试验开发中心(UCATS) 现有的癌症健康差异研究网络，包括六个NCI指定的综合癌症 中心：加州大学戴维斯分校，加州大学欧文分校健康赵家庭综合癌症中心(加州大学欧文分校)，加州大学洛杉矶分校 约翰森综合癌症中心(UCLA)，加州大学圣地亚哥·摩尔斯癌症中心，加州大学旧金山分校 海伦·迪勒家庭综合癌症中心(UCSF)和德克萨斯大学西南部哈罗德·C。 西蒙斯癌症中心(UTSW)。行政核心的作用是协调以下各项研究工作 为了最大限度地利用资金和资源，在不同的校区开展合作。行政核心成员 包括UCATS联系人PI，他在PDX方面进行了广泛研究，并拥有国内/国际 在癌症健康差距方面的领导专长。联系人PI，Carvajal-Carmona博士将负责 整个项目的管理。与联系PI密切合作，此核心将得到 生物统计师，五个现场PI，和一个UCD CRC，以帮助协调患者样本收集，两项研究 项目负责人和一名赠款管理员，以实施UCATS目标。行政核心将维持 与NCI工作人员、PDXNet数据共享和协调中心(PDCCC)、患者- 弗雷德里克国家癌症研究实验室(PDMR-FNLCR)的派生模型存储库，以及其他 PDX开发和试验中心(PDTC)制定标准操作程序(SOP)，协调 研究活动，交叉验证PDX研究，并将PDX模型存入PDXNet。管理核心将是 负责建立和维护中心的沟通和财务管理，以确保UCATS 将及时实现其目标。

PROJECT SUMMARY/ABSTRACT The overall goal of this application is to establish and characterize a large collection of minority patient-derived cancer xenografts (PDXs) from two cancer types (gastric and lung) and utilize these PDXs to guide cancer precision medicine decision making focusing on racial/ethnic minority populations. We established the University of California and UT Southwestern Diversity-PDX and Trial Development Center (UCaTS) that is built on an existing cancer health disparity research network, and includes six NCI-designated Comprehensive Cancer Centers: UC Davis, UC Irvine Health Chao Family Comprehensive Cancer Center (UC Irvine), UC Los Angeles Jonsson Comprehensive Cancer Center (UCLA), UC San Diego Moores Cancer Center, UC San Francisco Helen Diller Family Comprehensive Cancer Center (UCSF) and University of Texas Southwestern Harold C. Simmons Cancer Center (UTSW). The role of the Administrative Core is to coordinate the research effort among different campuses and to maximize the use of the funding and resources. The Administrative core members include UCaTS contact PI, who has conducted extensive research in PDXs and has national/international leadership expertise in cancer health disparities. The contact PI, Dr. Carvajal-Carmona, will be responsible for the overall program administration. Working closely with the contact PI, this Core will have support from a Biostatistician, five Site PIs, and a UCD CRC to help coordinate patient specimen collection, the two Research Project leads, and a grant administrator to operationalize UCaTS goals. The Administrative Core will maintain constant contact with the NCI staff, the PDXNet Data Commons and Coordinating Center (PDCCC), Patient- Derived Models Repository at Frederick National Laboratory for Cancer Research (PDMR-FNLCR), and other PDX Development and Trials Centers (PDTCs) to develop standard operating procedures (SOPs), coordinate research activities, cross-validate PDX research, and deposit PDX models into PDXNet. The Admin Core will be responsible for establishing and maintaining Center communication and fiscal management to ensure UCaTS will deliver its objectives in a timely manner.