Genetic studies of homologous recombination deficiency in hispanic gastric cancer

西班牙裔胃癌同源重组缺陷的遗传学研究

• 批准号: 10578426
• 负责人: Luis Guillermo Carvajal Carmona
• 金额: $ 5.91万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-08 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10578426
• 关键词: Address; Affect; BRCA1 gene; CDH1 gene; Cancer Etiology; Cancer Patient; Cessation of life; Clinical; Country; DNA; Data; Diagnosis; Disease; E-Cadherin; Early Diagnosis; Early treatment; Etiology; Funding; Gene Mutation; Genes; Genetic; Genetic Research; Genetic study; Genomics; Germ-Line Mutation; Hispanic; Hispanic Populations; Individual; Inherited; Latino; Latino Population; Malignant Neoplasms; Medicine; Minority; Modeling; Molecular; Mutation; Not Hispanic or Latino; PALB2 gene; Parents; Pathway interactions; Patients; Pattern; Penetrance; Population; Prevalence; RAD51C gene; Research; Risk; Risk Assessment; Risk Factors; SNP array; Sampling; Single Nucleotide Polymorphism; Statistical Data Interpretation; Stomach Neoplasms; Testing; The Cancer Genome Atlas; Time; Variant; Work; base; cancer genome; cancer health disparity; cancer risk; cancer survival; cancer therapy; cohort; driver mutation; early onset; exome sequencing; gastric cancer prevention; gene repair; high risk; homologous recombination; improved; individualized prevention; malignant stomach neoplasm; model building; molecular phenotype; molecular subtypes; mortality; mutation carrier; novel; parent grant; polygenic risk score; risk variant; screening program; survival disparity; survival outcome; tumor; whole genome

Scope of Work Aim 1: To identify candidate single nucleotide polymorphism selection in Hispanic gastric cancer patients and review discriminatory accuracy for polygenic modeling.ims in the project. Aim 2: To investigate the association of germline single nucleotide polymorphisms with mutation signatures and which has association in affecting the molecular subtype characterization of gastric tumors.

工作范围 目的1：确定拉美裔胃癌患者候选单核苷酸多态性选择 并审查项目中多基因建模.ims的判别性准确性。 目的2：探讨生殖系单核苷酸多态与突变的关系 这些信号与影响胃分子亚型特征的因素有关 肿瘤。