Building capacity for Global Infectious Disease Research Training in Schistosomiasis in sub-Saharan Africa

撒哈拉以南非洲血吸虫病全球传染病研究培训能力建设

• 批准号: 10731399
• 负责人: Alison Elliott
• 金额: $ 10.83万
• 依托单位: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-18 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10731399
• 关键词: Adult; Advisory Committees; Affect; Africa South of the Sahara; Artificial Intelligence; Behavior; Biology; Charge; Collaborations; Communities; Computational Biology; Country; Data; Data Science; Development; Disease Management; Disease Surveillance; Environment; Epidemiology; Exposure to; Faculty; Gastrointestinal Hemorrhage; Genomics; Goals; Grant; Health; Health Sciences; Immunity; Immunology; Infection; Infectious Diseases Research; Institution; Interdisciplinary Study; International; Intervention; Methodology; Modeling; Monitor; Needs Assessment; Population; Preparation; Prevention; Process; Production; Research; Research Institute; Research Training; Resources; Risk; Schistosoma; Schistosomiasis; Scientific Advances and Accomplishments; Scientist; Severity of illness; Therapeutic; Training; Training Programs; Uganda; Universities; Virus; Washington; career; college; design; disorder control; innovation; medical schools; multidisciplinary; organizational structure; programs; transmission process; vaccine candidate; vaccinology; vector; vector control; virtual

Program abstract This is an application for a two-year planning grant to build capacity for an international advanced research training in schistosomiasis in Uganda. The high burden of schistosomiasis in Uganda persists since the 1950’s Over 50% of the Ugandan population is at risk of exposure to Schistosoma species and its complications of fatal upper gastro-intestinal bleeding among adults. Gaps in control of schistosomiasis remain due to limited number of scientists with capacity to conduct advanced research and training focused on schistosomiasis epidemiology, vector biology, immunology, vaccinology, therapeutics, genomics, computational biology to model the schistosomiasis transmission, data science and artificial intelligence to model population behavior and other predictors of disease severity, as well as local development and production of effective vaccine candidates, and the application of locally generated data to inform relevant interventions for disease surveillance and control interventions in the affected communities. We propose to conduct a comprehensive needs assessment of the existing research and training capacity for schistosomiasis at Makerere University College of Health Sciences (MakCHS) and the collaborating institutions in Uganda (Uganda Virus Research Institute-UVRI, the Ministry of Vector Control Division in charge of schistosomiasis and other medical schools in the country). Findings from the needs assessment will be used to develop of an innovative research training and career enhancement program to strengthen capacity of scientists and health research professionals to conduct independent, multi-disciplinary research in schistosomiasis. During the two-year planning period we will hold multiple stakeholder engagements and identify the research training resources, local and international faculty, scientific environment contributions and administrative processes needed to undertake a schistosomiasis research training program. We will establish a strong executive committee to oversee the design and preparation of advanced scientific didactic and methodology courses (physical and virtual) and research training resources for schistosomiasis epidemiology, disease management, prevention, and control. We will also establish an international multi- disciplinary training advisory committee that will meet quarterly to guide and monitor the progress of the planning process against the set goals and milestones. The proposed planning grant will build on existing infection and immunity research training partnerships between MakCHS and UVRI, and long-standing research training collaborations with our US partners (John Hopkins University and University of Washington). We will reach out for new collaborations that may be required locally and abroad to establish a wholistic, multi-disciplinary network of scientists with an effective organizational structure that will support the envisioned research training program, and resultant collaborative five-year training program (D43) application for better control schistosomiasis in Uganda. 1

节目摘要 这是一项为期两年的规划拨款申请，旨在建设国际先进研究的能力 在乌干达开展血吸虫病培训。自疫情爆发以来，乌干达血吸虫病的沉重负担持续存在 20 世纪 50 年代 超过 50% 的乌干达人口面临接触血吸虫及其血吸虫的风险 成人致命性上消化道出血的并发症。血吸虫病控制方面的差距 由于有能力进行高级研究和培训的科学家数量有限，仍然存在 血吸虫病流行病学、媒介生物学、免疫学、疫苗学、治疗学、基因组学、 计算生物学模拟血吸虫病传播，数据科学和人工智能 模型人口行为和疾病严重程度的其他预测因素，以及当地的发展和 生产有效的候选疫苗，并应用本地生成的数据为相关人员提供信息 受影响社区的疾病监测和控制干预措施。我们建议 对现有研究和培训能力进行全面的需求评估 麦克雷雷大学健康科学学院 (MakCHS) 的血吸虫病和合作 乌干达机构（乌干达病毒研究所-UVRI、乌干达病媒控制司） 负责全国血吸虫病和其他医学院）。需求评估的结果 将用于制定创新的研究培训和职业提升计划，以加强 科学家和卫生研究专业人员进行独立、多学科研究的能力 在血吸虫病中。在两年规划期间，我们将举行多次利益相关者参与活动， 确定研究培训资源、本地和国际师资、科学环境贡献 开展血吸虫病研究培训计划所需的行政程序。我们将 建立一个强大的执行委员会来监督先进科学教学的设计和准备 血吸虫病方法学课程（实体和虚拟）和研究培训资源 流行病学、疾病管理、预防和控制。我们还将建立一个国际多 纪律培训咨询委员会每季度举行一次会议，指导和监督纪律培训的进展情况 根据既定目标和里程碑规划流程。拟议的规划拨款将建立在现有的基础上 MakCHS 和 UVRI 之间的感染和免疫研究培训伙伴关系以及长期的 与我们的美国合作伙伴（约翰霍普金斯大学和华盛顿大学）的研究培训合作。 我们将寻求本地和国外可能需要的新合作，以建立一个全面的、 具有有效组织结构的多学科科学家网络将支持 设想的研究培训计划以及由此产生的五年合作培训计划（D43）申请 以便更好地控制乌干达的血吸虫病。 1