Mitochondria electron transport chain complexes adaptative responses to cellular stress

线粒体电子传递链复合对细胞应激的适应性反应

基本信息

  • 批准号:
    10732145
  • 负责人:
  • 金额:
    $ 43.84万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-07-01 至 2028-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Radiotherapy is the most effective nonsurgical treatment for glioblastoma; however, therapeutic efficacy is severely limited due to the development of radioresistance (RR). In the hope of overcoming this urgent clinical problem, significant research has focused on defining the molecular mechanisms underlying RR. The overall objective of this application is to confirm the assembly of the ETC into mitochondrial respiratory supercomplexes (SCs) as a novel mechanism of RR. The central hypothesis of this proposal is that RR in GBM is the result of a rearrangement of the ETC complexes into SCs triggered by the expression of COX4-1, which promotes reprograming of glioma cell bioenergetics from predominantly aerobic glycolysis to mitochondrial oxidative phosphorylation and, consequently, reduces the mitochondrial production of reactive oxygen species (ROS). The specific aims proposed will use established glioma cell lines, patient-derived xenograft lines, preclinical animal models, and patient tumor samples to rigorously assess the validity of this hypothesis. Aim 1 will determine the role of CcO in SC assembly and mitochondrial metabolism. Aim 2 will evaluated the effects of SC on the regulation of ROS. Aim 3 will evaluate the role of SCs in the response of IR. We expect that data generated will vertically advance our understanding of how respiratory SCs affect outcomes in GBM and reveal the therapeutic vulnerability in RR GBM than can be exploited by SC- disrupting agents.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Corinne E. Griguer其他文献

Targeting glioblastoma multiforme cells with pharmacological ascorbate: Disrupting DNA damage response and mTOR cascades emvia/em extracellular Hsub2/subOsub2/sub
用药理抗坏血酸靶向多形性胶质母细胞瘤细胞:通过细胞外 H₂O₂ 破坏 DNA 损伤反应和 mTOR 级联反应
  • DOI:
    10.1016/j.freeradbiomed.2025.06.008
  • 发表时间:
    2025-09-01
  • 期刊:
  • 影响因子:
    8.200
  • 作者:
    Naphat Chantaravisoot;Kittipong Sanookpan;Onsurang Wattanathamsan;Rungnapa Bootsri;Tankun Banlue;Chatchapon Chuenjit;Nuttiya Kalpongnukul;Claudia R. Oliva;Corinne E. Griguer;Visarut Buranasudja
  • 通讯作者:
    Visarut Buranasudja

Corinne E. Griguer的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Corinne E. Griguer', 18)}}的其他基金

Paracrine Signaling in Glioma: Bioenergetics Heterogeneity and Chemoresistance
神经胶质瘤中的旁分泌信号传导:生物能异质性和化疗耐药性
  • 批准号:
    9221192
  • 财政年份:
    2016
  • 资助金额:
    $ 43.84万
  • 项目类别:
Cytochrome C Oxidase in Malignant Gliomas
恶性胶质瘤中的细胞色素 C 氧化酶
  • 批准号:
    9027806
  • 财政年份:
    2012
  • 资助金额:
    $ 43.84万
  • 项目类别:
Cytochrome C Oxidase in Malignant Gliomas
恶性胶质瘤中的细胞色素 C 氧化酶
  • 批准号:
    8297145
  • 财政年份:
    2012
  • 资助金额:
    $ 43.84万
  • 项目类别:
Cytochrome C Oxidase in Malignant Gliomas
恶性胶质瘤中的细胞色素 C 氧化酶
  • 批准号:
    8828116
  • 财政年份:
    2012
  • 资助金额:
    $ 43.84万
  • 项目类别:
Cytochrome C Oxidase in Malignant Gliomas
恶性胶质瘤中的细胞色素 C 氧化酶
  • 批准号:
    8643090
  • 财政年份:
    2012
  • 资助金额:
    $ 43.84万
  • 项目类别:
Cytochrome C Oxidase in Malignant Gliomas
恶性胶质瘤中的细胞色素 C 氧化酶
  • 批准号:
    8464672
  • 财政年份:
    2012
  • 资助金额:
    $ 43.84万
  • 项目类别:
Mitochondrial Dysfunction and Chemoresistance in Malignant Gliomas
恶性胶质瘤的线粒体功能障碍和化疗耐药
  • 批准号:
    8007374
  • 财政年份:
    2010
  • 资助金额:
    $ 43.84万
  • 项目类别:
Mitochondrial Dysfunction and Chemoresistance in Malignant Gliomas
恶性胶质瘤的线粒体功能障碍和化疗耐药
  • 批准号:
    7787101
  • 财政年份:
    2010
  • 资助金额:
    $ 43.84万
  • 项目类别:

相似海外基金

Double Incorporation of Non-Canonical Amino Acids in an Animal and its Application for Precise and Independent Optical Control of Two Target Genes
动物体内非规范氨基酸的双重掺入及其在两个靶基因精确独立光学控制中的应用
  • 批准号:
    BB/Y006380/1
  • 财政年份:
    2024
  • 资助金额:
    $ 43.84万
  • 项目类别:
    Research Grant
Quantifying L-amino acids in Ryugu to constrain the source of L-amino acids in life on Earth
量化 Ryugu 中的 L-氨基酸以限制地球生命中 L-氨基酸的来源
  • 批准号:
    24K17112
  • 财政年份:
    2024
  • 资助金额:
    $ 43.84万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Collaborative Research: RUI: Elucidating Design Rules for non-NRPS Incorporation of Amino Acids on Polyketide Scaffolds
合作研究:RUI:阐明聚酮化合物支架上非 NRPS 氨基酸掺入的设计规则
  • 批准号:
    2300890
  • 财政年份:
    2023
  • 资助金额:
    $ 43.84万
  • 项目类别:
    Continuing Grant
Basic research toward therapeutic strategies for stress-induced chronic pain with non-natural amino acids
非天然氨基酸治疗应激性慢性疼痛策略的基础研究
  • 批准号:
    23K06918
  • 财政年份:
    2023
  • 资助金额:
    $ 43.84万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Molecular mechanisms how arrestins that modulate localization of glucose transporters are phosphorylated in response to amino acids
调节葡萄糖转运蛋白定位的抑制蛋白如何响应氨基酸而被磷酸化的分子机制
  • 批准号:
    23K05758
  • 财政年份:
    2023
  • 资助金额:
    $ 43.84万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Molecular recognition and enantioselective reaction of amino acids
氨基酸的分子识别和对映选择性反应
  • 批准号:
    23K04668
  • 财政年份:
    2023
  • 资助金额:
    $ 43.84万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Design and Synthesis of Fluorescent Amino Acids: Novel Tools for Biological Imaging
荧光氨基酸的设计与合成:生物成像的新工具
  • 批准号:
    2888395
  • 财政年份:
    2023
  • 资助金额:
    $ 43.84万
  • 项目类别:
    Studentship
Structurally engineered N-acyl amino acids for the treatment of NASH
用于治疗 NASH 的结构工程 N-酰基氨基酸
  • 批准号:
    10761044
  • 财政年份:
    2023
  • 资助金额:
    $ 43.84万
  • 项目类别:
Lifestyle, branched-chain amino acids, and cardiovascular risk factors: a randomized trial
生活方式、支链氨基酸和心血管危险因素:一项随机试验
  • 批准号:
    10728925
  • 财政年份:
    2023
  • 资助金额:
    $ 43.84万
  • 项目类别:
Single-molecule protein sequencing by barcoding of N-terminal amino acids
通过 N 端氨基酸条形码进行单分子蛋白质测序
  • 批准号:
    10757309
  • 财政年份:
    2023
  • 资助金额:
    $ 43.84万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了