Establishing that sleep spindle and slow wave deficits are present, are associated with cognitive dysfunction, and can be acutely manipulated in early course schizophrenia

确定睡眠纺锤波和慢波缺陷的存在，与认知功能障碍相关，并且可以在早期精神分裂症中进行急性控制

• 批准号: 10733615
• 负责人: Fabio Ferrarelli
• 金额: $ 75.93万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733615
• 关键词: Acoustic Stimulation; Acute; Affect; Brain; Chronic; Chronic Schizophrenia; Clinical; Cognition; Cognitive; Cognitive deficits; Correlative Study; Crossover Design; Data; Diagnosis; Disease; Double-Blind Method; Early Intervention; Early treatment; Electroencephalography; Goals; Health Care Costs; Impaired cognition; Impairment; Individual; Intervention; Laboratories; Link; Measures; Motor; Napping; Neurobiology; Onset of illness; Participant; Patients; Performance; Research; Role; Schizophrenia; Short-Term Memory; Sleep; Stage II Sleep; System; Task Performances; Translating; Waxes; Work; auditory stimulus; cognitive change; cognitive control; cognitive function; cognitive performance; comparison group; density; disability; functional outcomes; improved; improvement on sleep; memory consolidation; non rapid eye movement; novel; sleep spindle; wireless; wireless electronic

Project Summary. In Schizophrenia (SCZ), early interventions can make a difference, particularly for cognitive dysfunction, a core feature of SCZ that predicts poorer clinical trajectories and functional outcomes. Cognitive impairments in SCZ have been linked to abnormalities in sleep and sleep-specific oscillations—spindles and slow waves— which have been established in SCZ, although mostly in chronic patients. As first steps towards translating these observations into novel, timely interventions, we aim to establish: whether sleep oscillatory and cognitive deficits are present in early course (EC-SCZ) patients vs. healthy controls (HC), and if these deficits are related to each other; and 2) whether sleep manipulation with auditory stimulation can improve sleep oscillation deficits in EC-SCZ, and if sleep oscillatory changes are related to cognitive changes in these patients. Sleep spindles are waxing and waning, 12-16 Hz oscillations that represent the hallmark of NREM stage 2 sleep. Slow waves are large amplitude, ~1 Hz brain oscillations that characterize NREM stage 3. We and others have demonstrated marked deficits in sleep spindles, and to a lesser extent, slow waves in SCZ and reduced spindle density is associated with worse memory consolidation (MC), a key cognitive function known to be altered in SCZ. However, most of the evidence is in chronic SCZ, while the presence of altered sleep oscillations and MD at illness onset would establish these features as robust markers of SCZ. Thus, the first goal of this proposal is to establish whether spindle and slow wave deficits are present and are associated with reduced MC performance in EC-SCZ patients relative to HC. We will also examine the association between sleep oscillatory deficits and cognitive controls (CC) and working memory (WM), cognitive functions that have been linked to spindles and slow waves in HC and are impaired in EC-SCZ patients. To establish whether ameliorating sleep alterations may contribute to novel treatment interventions, we first need to ascertain that sleep and sleep oscillatory deficits can be manipulated. An EEG closed-loop system, which delivers auditory stimuli during sleep, consistently enhances slow wave and spindle activity in HC. This system, which involves using a wireless device, can be employed with a simultaneous polysomnogram (PSG) in the sleep laboratory to enhance feasibility and validity. However, no study has used this closed-loop approach in SCZ. The second goal of this proposal is to demonstrate that sleep spindles and slow waves deficits can be acutely modified with closed-loop auditory stimulation (CLAS) during sleep in EC-SCZ patients and to examine whether CLAS-related spindle and slow wave changes are associated with cognitive changes in these patients. We propose to perform wireless/PSG overnight sleep recordings and assess performance in the motor sequence tapping (MST), a MC task, as the main cognitive measure and performance in the AX-CPT for CC and WM as a secondary cognitive measure, in 70 EC-SCZ and 70 HC subjects. EC-SCZ patients will also undergo auditory stimulation and sham nights in a double-blind, cross-over design with sleep, MST, and AX-CPT assessments.

项目总结。在精神分裂症（SCZ）中，早期干预可以产生影响，特别是在认知方面