Chronic Kidney Disease in Children (CKiD V)

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PROJECT SUMMARY/ABSTRACT For the Chronic Kidney Disease in Children (CKiD) Study renewal, we will continue to follow our existing cohort, and will recruit children between 14 and 17 years of age to enhance the power of the study to characterize the decline of kidney function and the development of cardiovascular disease as they transition to young adulthood. Remote data collection will be coordinated and conducted through national laboratory contractors who can assess vitals and obtain labs in the participant’s home. Data will be obtained between CKiD study visits by conducting data extraction through electronic health records. The Research Electronic Data Capture (REDCap) system will be leveraged to allow automated reporting for coordination and clinical activities and improve options for harmonization with external cohorts including CureGN and NEPTUNE. Most importantly, it will enable the study to collect data through web-based entry by computer or mobile phone directly by participants. Important research questions will include (a) methods to identify risk factors for decline in kidney function during childhood through young adulthood including acceleration of glomerular filtration rate (GFR) decline during puberty and the effect of acute kidney injury (AKI) on chronic kidney disease (CKD); (b) statistical-based machine learning prediction methodology to characterize the joint predictive value of clinical markers and social determinants of disease progression for individualized inference; (c) analytic strategies to describe risk factors for cardiovascular changes and outcomes via home blood pressure monitoring and assessing cardiac and vascular target organ damage, including characterizing changes in biomarkers like trajectories of indicators of metabolic bone health; (d) statistical methods to validate and refine GFR equations in young adulthood for consistent estimates during the transition from pediatric to adult care; and (e) methods to assess effects of therapies and exposures on outcomes including constructs of social function and emotional well-being.