Cross Training Core

交叉训练核心

• 批准号: 10704717
• 负责人: OMAR MIAN
• 金额: $ 12.8万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-14 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704717
• 关键词: Acceleration; Address; Adoption; Basic Science; Biological; Biology; Caliber; Cancer Biology; Cause of Death; Clinic; Clinical; Clinical Trials; Collaborations; Combined Modality Therapy; Communities; Community Clinical Oncology Program; Comprehensive Cancer Center; Data; Detection; Development; Disabled Persons; Doctor of Philosophy; Education; Educational Curriculum; Ensure; Environment; Faculty Workshop; Fostering; Foundations; Future; Genomics; Goals; Informatics; Institution; Internships; Knowledge acquisition; Malignant Neoplasms; Medical; Mentors; Mentorship; Minority; Mission; Molecular; Patient Care; Patient-Focused Outcomes; Persons; Physicians; Physics; Postdoctoral Fellow; Program Development; Public Health; Quality of Care; Radiation; Radiation Oncologist; Radiation Oncology; Radiobiology; Research; Research Personnel; Resources; Rotation; Sampling; Science; Scientist; Services; Site; Standardization; Talents; Techniques; Training; Training Programs; Training and Education; Translating; Translations; Treatment Efficacy; Universities; Woman; Workforce Development; anticancer research; cancer diagnosis; career; clinical practice; clinically significant; collaborative environment; commune; community engagement; data sharing; experience; immunoregulation; improved; informatics tool; innovation; insight; leadership development; meetings; multidisciplinary; next generation; programs; recruit; skills; targeted treatment; tool; training opportunity; virtual

PROJECT SUMMARY Cross-Training Core Cancer is a major public health problem worldwide and is the second leading cause of death in the US. Advances in our understanding of the biology of cancer have the potential to lead to significant breakthroughs in cancer diagnosis, detection, and treatment. However, the translation of basic science discoveries to clinical advancements has been slow and inefficient. The translation of molecular insights from the lab to clinical trials and ultimately to clinical practice relies on the close collaboration of scientists (radiation biologist and medical physicist) and physicians (radiation oncologist) with diverse training backgrounds. A major barrier to the integration of these basic scientists and physicians in translational settings is the lack of enhanced mentored training opportunities focused on radiation biology workforce development. To address the urgent need for well-trained independent investigators in cancer research who can bridge the gap between scientific discovery and clinical advancement, we propose the Cleveland Clinic Foundation (CCF)-Emory Cross-Training Program in ROBIN that will take advantage of the outstanding resources, high caliber of investigators, and close collaboration between cancer biologists, clinicians and physicists at the Cleveland Clinic Case Comprehensive Cancer Center and Winship Cancer Institute of Emory University. The CCF/Emory Cross-Training Core will provide a unique, individualized, and multi-faceted cross-training experience to support the development of trainees (PhD and/or MD) in acquiring the knowledge and skills to address the most important biological questions and clinically significant problems so that they can make transformative discoveries to improve quality of care for patients with cancer. The primary objective of the Cross-Training Core is to develop and sustain a collaborative environment that encourages the center membership to increase interactions, sharing, and rapid adoption of concepts and approaches. The cross-training core will establish and accelerate advances from projects to paradigms by providing training and expertise with an overall trajectory that promotes wider adoption by the oncology community to improve patient outcomes. We will operationalize the mission of the cross-training core through integrated training opportunities for radiation biologists, medical physicists, and radiation oncologists with the goal of engaging trainees in research across the ROBIN Center’s multiple cores and projects. Building on a strong existing culture of education and training, we propose the following specific aims: (1) Develop a centralized radiation biology integration network to facilitate scientific cross-pollination between radiation oncology, radiation biology, and medical physics within the ROBIN Center; (2) Disseminate clinical / translational data from Cores, Projects, and Molecular Characterization Trials across the center with the broader mission of fostering cross disciplinary training and collaboration; (3) Develop a ROBIN center wide workforce development program relying on interdisciplinary training for clinicians, physicists and radiation biologists in translational radiation biology.

项目概要 交叉训练核心 癌症是全球主要的公共卫生问题，也是美国第二大死因。 我们对癌症生物学理解的进步有可能带来重大突破 在癌症诊断、检测和治疗方面。然而，将基础科学发现转化为临床 进展缓慢且低效。将分子见解从实验室转化为临床试验 最终走向临床实践依赖于科学家（放射生物学家和医学家）的密切合作 物理学家）和具有不同培训背景的医师（放射肿瘤学家）。的一个主要障碍 这些基础科学家和医生在转化环境中的整合缺乏强化的指导 培训机会侧重于辐射生物学劳动力发展。为解决迫切需要 训练有素的癌症研究独立研究人员可以弥合科学发现之间的差距 和临床进步，我们提出克利夫兰诊所基金会 (CCF)-埃默里交叉培训计划 ROBIN 将利用优秀的资源、高素质的调查人员以及密切的合作伙伴关系 克利夫兰诊所癌症生物学家、临床医生和物理学家之间的合作案例综合 埃默里大学癌症中心和温希普癌症研究所。 CCF/埃默里交叉培训核心将 提供独特、个性化、多方位的交叉培训体验，支持员工的发展 受训者（博士和/或医学博士）获得解决最重要的生物学问题的知识和技能 问题和临床上的重大问题，以便他们能够做出变革性的发现来改善 癌症患者的护理质量。交叉培训核心的主要目标是开发和 维持一个协作环境，鼓励中心成员增加互动、分享、 以及概念和方法的快速采用。交叉培训核心将建立并加速 通过提供具有总体轨迹的培训和专业知识，从项目到范式的进展 促进肿瘤学界更广泛采用，以改善患者的治疗结果。我们将实施 交叉培训核心的使命是通过为放射生物学家、医学家提供综合培训机会 物理学家和放射肿瘤学家的目标是让学员参与罗宾中心的研究 多个核心和项目。以现有的强大教育和培训文化为基础，我们提出 具体目标如下： (1) 建立集中式放射生物学集成网络，以促进科学 ROBIN 中心内放射肿瘤学、放射生物学和医学物理学之间的交叉授粉； (2) 在各个领域传播来自核心、项目和分子表征试验的临床/转化数据 该中心具有促进跨学科培训和合作的更广泛使命； (3) 开发一个 ROBIN 中心范围内的劳动力发展计划依赖于临床医生的跨学科培训， 转化辐射生物学领域的物理学家和辐射生物学家。