Cross Training Core

项目摘要 交叉训练核心 癌症是世界范围内的主要公共卫生问题，也是美国的第二大死亡原因。 我们对癌症生物学的理解的进步有可能导致重大突破 癌症诊断、检测和治疗。然而，将基础科学发现转化为临床 进展缓慢，效率低下。将分子见解从实验室转化为临床试验 并最终用于临床实践依赖于科学家（放射生物学家和医学家）的密切合作。 物理学家）和医生（放射肿瘤学家）具有不同的培训背景。的主要障碍 这些基础科学家和医生在翻译环境中的整合是缺乏增强的指导， 培训机会侧重于辐射生物学工作人员的发展。为了解决迫切需要 在癌症研究中训练有素的独立调查人员，他们可以弥合科学发现与科学研究之间的差距。 和临床进步，我们提出了克利夫兰诊所基金会（CCF）-埃默里交叉培训计划 在罗宾，将利用优秀的资源，高素质的调查人员，并关闭 癌症生物学家，临床医生和物理学家之间的合作，在克利夫兰诊所病例综合 埃默里大学癌症中心和温希普癌症研究所。CCF/Emory交叉培训核心将 提供一个独特的，个性化的，多方面的交叉培训经验，以支持发展 培训生（博士和/或医学博士）在获得知识和技能，以解决最重要的生物 问题和临床上重要的问题，以便他们能够做出变革性的发现， 癌症患者的护理质量。交叉培训核心的主要目标是开发和 维持一个协作的环境，鼓励中心成员增加互动，分享， 迅速采用概念和方法。交叉训练核心将建立并加速 通过提供培训和专业知识，从项目到范例的进步， 促进肿瘤学界更广泛的采用，以改善患者的治疗效果。我们将实施 交叉培训核心的使命，通过为放射生物学家、医学专家、 物理学家和放射肿瘤学家，目标是让受训者参与罗宾中心的研究。 多个核心和项目。在现有的良好教育和培训文化基础上，我们建议 （1）建立一个集中的辐射生物学综合网络， 辐射肿瘤学、辐射生物学和ROBIN中心内的医学物理学之间的交叉授粉; (2)传播来自核心、项目和分子表征试验的临床/翻译数据， 该中心具有促进跨学科培训和合作的更广泛的使命;（3）开发一个 ROBIN中心范围内的劳动力发展计划依赖于临床医生的跨学科培训， 物理学家和辐射生物学家在转化辐射生物学。

PROJECT SUMMARY Cross-Training Core Cancer is a major public health problem worldwide and is the second leading cause of death in the US. Advances in our understanding of the biology of cancer have the potential to lead to significant breakthroughs in cancer diagnosis, detection, and treatment. However, the translation of basic science discoveries to clinical advancements has been slow and inefficient. The translation of molecular insights from the lab to clinical trials and ultimately to clinical practice relies on the close collaboration of scientists (radiation biologist and medical physicist) and physicians (radiation oncologist) with diverse training backgrounds. A major barrier to the integration of these basic scientists and physicians in translational settings is the lack of enhanced mentored training opportunities focused on radiation biology workforce development. To address the urgent need for well-trained independent investigators in cancer research who can bridge the gap between scientific discovery and clinical advancement, we propose the Cleveland Clinic Foundation (CCF)-Emory Cross-Training Program in ROBIN that will take advantage of the outstanding resources, high caliber of investigators, and close collaboration between cancer biologists, clinicians and physicists at the Cleveland Clinic Case Comprehensive Cancer Center and Winship Cancer Institute of Emory University. The CCF/Emory Cross-Training Core will provide a unique, individualized, and multi-faceted cross-training experience to support the development of trainees (PhD and/or MD) in acquiring the knowledge and skills to address the most important biological questions and clinically significant problems so that they can make transformative discoveries to improve quality of care for patients with cancer. The primary objective of the Cross-Training Core is to develop and sustain a collaborative environment that encourages the center membership to increase interactions, sharing, and rapid adoption of concepts and approaches. The cross-training core will establish and accelerate advances from projects to paradigms by providing training and expertise with an overall trajectory that promotes wider adoption by the oncology community to improve patient outcomes. We will operationalize the mission of the cross-training core through integrated training opportunities for radiation biologists, medical physicists, and radiation oncologists with the goal of engaging trainees in research across the ROBIN Center’s multiple cores and projects. Building on a strong existing culture of education and training, we propose the following specific aims: (1) Develop a centralized radiation biology integration network to facilitate scientific cross-pollination between radiation oncology, radiation biology, and medical physics within the ROBIN Center; (2) Disseminate clinical / translational data from Cores, Projects, and Molecular Characterization Trials across the center with the broader mission of fostering cross disciplinary training and collaboration; (3) Develop a ROBIN center wide workforce development program relying on interdisciplinary training for clinicians, physicists and radiation biologists in translational radiation biology.