Cross Training Core

交叉训练核心

• 批准号: 10526307
• 负责人: OMAR MIAN
• 金额: $ 14.83万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-14 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10526307
• 关键词: Address; Adoption; Basic Science; Biological; Biology; Caliber; Cancer Biology; Cause of Death; Clinic; Clinical; Clinical Trials; Collaborations; Combined Modality Therapy; Communities; Community Clinical Oncology Program; Comprehensive Cancer Center; Data; Detection; Development; Disabled Persons; Doctor of Philosophy; Education; Educational Curriculum; Ensure; Environment; Faculty Workshop; Fostering; Foundations; Future; Genomics; Goals; Informatics; Institutes; Internships; Knowledge; Lead; Malignant Neoplasms; Medical; Mentors; Mentorship; Minority Groups; Mission; Molecular; Patient Care; Patient-Focused Outcomes; Persons; Physicians; Physics; Postdoctoral Fellow; Program Development; Public Health; Quality of Care; Radiation; Radiation Oncologist; Radiation Oncology; Radiobiology; Research; Research Personnel; Resources; Rotation; Sampling; Science; Scientist; Services; Site; Standardization; Talents; Techniques; Training; Training Programs; Training and Education; Translating; Translations; Treatment Efficacy; Universities; Woman; Workforce Development; anticancer research; base; cancer diagnosis; career; clinical practice; clinically significant; collaborative environment; commune; community engagement; data sharing; experience; immunoregulation; improved; informatics tool; innovation; insight; leadership development; meetings; multidisciplinary; next generation; programs; recruit; skills; targeted treatment; tool; training opportunity; virtual

PROJECT SUMMARY Cross-Training Core Cancer is a major public health problem worldwide and is the second leading cause of death in the US. Advances in our understanding of the biology of cancer have the potential to lead to significant breakthroughs in cancer diagnosis, detection, and treatment. However, the translation of basic science discoveries to clinical advancements has been slow and inefficient. The translation of molecular insights from the lab to clinical trials and ultimately to clinical practice relies on the close collaboration of scientists (radiation biologist and medical physicist) and physicians (radiation oncologist) with diverse training backgrounds. A major barrier to the integration of these basic scientists and physicians in translational settings is the lack of enhanced mentored training opportunities focused on radiation biology workforce development. To address the urgent need for well-trained independent investigators in cancer research who can bridge the gap between scientific discovery and clinical advancement, we propose the Cleveland Clinic Foundation (CCF)-Emory Cross-Training Program in ROBIN that will take advantage of the outstanding resources, high caliber of investigators, and close collaboration between cancer biologists, clinicians and physicists at the Cleveland Clinic Case Comprehensive Cancer Center and Winship Cancer Institute of Emory University. The CCF/Emory Cross-Training Core will provide a unique, individualized, and multi-faceted cross-training experience to support the development of trainees (PhD and/or MD) in acquiring the knowledge and skills to address the most important biological questions and clinically significant problems so that they can make transformative discoveries to improve quality of care for patients with cancer. The primary objective of the Cross-Training Core is to develop and sustain a collaborative environment that encourages the center membership to increase interactions, sharing, and rapid adoption of concepts and approaches. The cross-training core will establish and accelerate advances from projects to paradigms by providing training and expertise with an overall trajectory that promotes wider adoption by the oncology community to improve patient outcomes. We will operationalize the mission of the cross-training core through integrated training opportunities for radiation biologists, medical physicists, and radiation oncologists with the goal of engaging trainees in research across the ROBIN Center’s multiple cores and projects. Building on a strong existing culture of education and training, we propose the following specific aims: (1) Develop a centralized radiation biology integration network to facilitate scientific cross-pollination between radiation oncology, radiation biology, and medical physics within the ROBIN Center; (2) Disseminate clinical / translational data from Cores, Projects, and Molecular Characterization Trials across the center with the broader mission of fostering cross disciplinary training and collaboration; (3) Develop a ROBIN center wide workforce development program relying on interdisciplinary training for clinicians, physicists and radiation biologists in translational radiation biology.

项目摘要 交叉训练核心 癌症是全球主要的公共卫生问题，是美国第二大死亡原因。 我们对癌症生物学的理解的进步有可能导致重大突破 在癌症诊断，检测和治疗中。但是，将基础科学发现翻译成临床 进步缓慢且效率低下。分子见解从实验室转换为临床试验 最终，临床实践依赖于科学家的密切合作（放射线生物学家和医学 物理学家）和具有潜水员培训背景的医师（放射肿瘤学家）。一个主要的障碍 这些基本科学家和医生在翻译环境中的整合是缺乏增强的重要事项 培训机会集中在辐射生物学劳动力发展上。满足迫切需求 训练良好的癌症研究独立研究人员，他们可以弥合科学发现之间的差距 和临床进步，我们提出了克利夫兰诊所基金会（CCF） - 官员交叉训练计划 在罗宾（Robin 克利夫兰诊所案例综合的癌症生物学家，临床医生和物理学家之间的合作 埃默里大学癌症中心和温船癌研究所。 CCF/Emory交叉训练核心将 提供独特，个性化和多面的交叉训练经验，以支持 学员（博士学位和/或MD）辅助知识和技能以解决最重要的生物学 问题和临床上重要的问题，以便他们可以进行变革性发现以改进 癌症患者的护理质量。交叉训练核心的主要目的是发展和 维持一个协作环境，鼓励中心成员增加互动，共享， 并快速采用概念和方法。交叉训练核心将建立和加速 通过提供培训和专业知识的整体轨迹，从项目到范式的进步 促进肿瘤学社区的广泛采用，以改善患者的结果。我们将经营 通过辐射生物学家的综合培训机会，交叉训练核心的任务，医疗 物理学家和辐射肿瘤学家的目标是吸引学员参与罗宾中心的研究 多个核心和项目。以强烈的现有教育和培训文化为基础，我们建议 以下特定目的：（1）开发集中式辐射生物学整合网络，以促进科学 辐射肿瘤学，辐射生物学和罗宾中心的医学物理学之间的交叉授粉； （2）从核心，项目和分子表征试验中传播临床 /翻译数据 该中心具有更广泛的使命，即培养跨学科培训和协作； （3）开发 罗宾中心广泛的劳动力发展计划，依靠临床医生的跨学科培训， 翻译辐射生物学中的物理学家和辐射生物学家。