Administrative Core

行政核心

• 批准号: 10705296
• 负责人: Michelle Denburg
• 金额: $ 43.12万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-18 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705296
• 关键词: Acceleration; Address; Advisory Committees; Awareness; Basic Science; Big Data; Biological; Biomedical Research; Child; Childhood; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communities; Comparative Effectiveness Research; Data; Development; Education; Effectiveness; Electronic Health Record; Epidemiology; Faculty; Family; Feasibility Studies; Fostering; Foundations; Future; Genomics; Goals; Health Services Research; Health system; Individual; Informatics; Infrastructure; Institution; Interdisciplinary Study; International; Kidney Diseases; Knowledge; Leadership; Learning; Longevity; Mentors; Methods; Mission; Molecular; Multi-Institutional Clinical Trial; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Observational Study; Outcome; Patients; Pediatric Hospitals; Peer Review; Pennsylvania; Philadelphia; Pilot Projects; Policies; Positioning Attribute; Pragmatic clinical trial; Productivity; Records; Research; Research Methodology; Research Personnel; Research Project Grants; Sampling; Scholars Program; Talents; Therapeutic; Training; Translational Research; Universities; Vulnerable Populations; Work; base; career; career development; clinical investigation; clinical phenotype; clinical trial implementation; cohesion; community engagement; comparative effectiveness; comparative effectiveness trial; design; evidence base; experience; human subject protection; human tissue; improved; innovation; interest; medical schools; meetings; member; molecular phenotype; new therapeutic target; novel; organizational structure; pragmatic trial; prevent; programs; skills; success; transcriptomic profiling; virtual; web site

ADMINISTRATIVE CORE PROJECT SUMMARY The overall goal of the Administrative Core is to provide direction, guidance, and oversight for the PCEN and assure its effective and efficient functioning. The Administrative Core will facilitate the work of the two Biomedical Research Cores, the Learning Health System Core (LHS Core) and the Molecular Precision Nephrology Core (MPNC), and support the Enrichment Program, Opportunity Pool Pilot and Feasibility Program, and two Research Projects. The Enrichment Program aims to equip the research base with additional skill sets and maximizes interactions and intellectual discourse within the PCEN. Initiatives within the Enrichment Program will encourage and support innovative multidisciplinary research in pediatric kidney disease through early career engagement, including the Summer Scholar program; career development and collaborations; and patient, family, and community engagement. The Opportunity Pool Pilot and Feasibility Programwill continue to stimulate and solicit new project ideas to address key barriers to research progress in pediatric nephrology, specifically for early stage investigators, new investigators, or established investigators not previously involved in research on pediatric kidney disease. The CHOP PCEN organizational structure includes oversight by an External Advisory Board (EAB) and input and guidance from a Scientific Advisory Committee (SAC). The Steering Committee will set overall policy for the CHOP PCEN and will include the Center Co-Directors, the SAC Chair, the Biomedical Core Directors and leadership, and the ProgramLeads. In addition to facilitating collaborations across the CHOP PCEN collaborators at CHOP, the University of Pennsylvania, and Johns Hopkins University, the Administrative Core will support interdisciplinary partnerships across the CHOP PCEN research base and the PCEN Network. Our team includes individuals with proven track records in mentoring, basic science, translational research, clinical investigation, epidemiology, informatics, and health services research. We will build upon the success of our established PCEN to expand the evidence base of observational data for clinical trial design and enhance the infrastructure for pragmatic clinical trials and comparative effectiveness through the LHS Core; facilitate the identification of novel therapeutic targets through the MPNC; foster collaboration in kidney disease research across other centers; and mentor members of the broader nephrology community by supporting the Enrichment Program, an Opportunity Pool Program, and innovative research projects in childhood kidney disease.

行政核心项目总结 行政核心的总体目标是为PCEN和 确保其有效和高效地运作。行政核心将促进两个生物医学中心的工作 研究核心、学习健康系统核心(LHS核心)和分子精密肾病核心 (MPNC)，并支持丰富计划、机会池试点和可行性计划，以及两个 研究项目。丰富计划旨在为研究基地配备更多的技能和 最大限度地促进PCEN内部的互动和知识交流。丰富计划中的计划将 通过早期职业生涯鼓励和支持儿童肾脏疾病的创新多学科研究 参与度，包括暑期奖学金计划；职业发展和合作；以及耐心， 家庭和社区参与。机会池试点和可行性计划将继续刺激 并征集新的项目想法，以解决儿童肾病研究进展的主要障碍，特别是 早期调查人员、新调查人员或以前没有参与过研究的现有调查人员 儿科肾脏疾病。CHOP PCEN组织结构包括外部顾问的监督 委员会(EAB)和科学咨询委员会(SAC)的投入和指导。指导委员会将 为CHOP PCEN制定总体政策，并将包括中心联席主任、SAC主席、生物医学 核心导演和领导力，以及节目负责人。除了促进跨部门的协作 宾夕法尼亚大学CHOP和行政部门约翰·霍普金斯大学的PCEN合作者 CORE将支持CHOP PCEN研究基地和PCEN网络的跨学科伙伴关系。 我们的团队包括在指导、基础科学、翻译研究、 临床调查、流行病学、信息学和卫生服务研究。我们将在成功的基础上继续 我们成立了PCEN，为临床试验设计扩大观察数据的证据基础，并增强 通过LHS核心为务实的临床试验和比较有效性提供基础设施；促进 通过MPNC确定新的治疗靶点；促进肾脏疾病研究中的合作 跨其他中心；并通过支持浓缩来指导更广泛的肾脏病社区成员 计划、机会池计划和儿童肾脏疾病的创新研究项目。