Administrative Core

行政核心项目摘要 行政核心的总体目标是为PCEN提供方向、指导和监督， 确保其有效和高效运作。行政核心将促进两个生物医学中心的工作， 研究核心，学习健康系统核心（LHS核心）和分子精密肾病核心 （MPNC），并支持丰富计划，机会池试点和可行性计划，以及两个 研究项目。充实计划旨在为研究基地配备额外的技能组合， 最大化PCEN内部的互动和知识话语。强化计划中的举措将 通过早期职业生涯鼓励和支持儿科肾脏疾病的创新多学科研究 参与，包括暑期奖学金计划;职业发展和合作;和病人， 家庭和社区参与。机会池试点和可行性计划将继续刺激 并征求新的项目想法，以解决儿科肾脏病学研究进展的关键障碍，特别是 早期研究者、新研究者或以前未参与研究的已建立研究者 小儿肾病CHOP PCEN的组织结构包括外部顾问的监督 委员会（EAB）和科学咨询委员会（SAC）的投入和指导。指导委员会将 为CHOP PCEN制定总体政策，并将包括中心联合主任、SAC主席、生物医学 核心董事和领导，以及程序领导。除了促进整个CHOP的合作外， PCEN在CHOP、宾夕法尼亚大学和约翰霍普金斯大学的合作者， 核心将支持跨CHOP PCEN研究基地和PCEN网络的跨学科伙伴关系。 我们的团队包括在指导，基础科学，转化研究， 临床调查、流行病学、信息学和卫生服务研究。我们将继续努力， 我们建立了PCEN，以扩大临床试验设计的观察数据的证据基础， 通过LHS核心，建立实用的临床试验和比较有效性的基础设施; 通过MPNC确定新的治疗靶点;促进肾脏疾病研究方面的合作 在其他中心;和指导更广泛的肾脏学社区的成员，通过支持丰富的 计划，一个机会池计划，和儿童肾脏疾病的创新研究项目。

ADMINISTRATIVE CORE PROJECT SUMMARY The overall goal of the Administrative Core is to provide direction, guidance, and oversight for the PCEN and assure its effective and efficient functioning. The Administrative Core will facilitate the work of the two Biomedical Research Cores, the Learning Health System Core (LHS Core) and the Molecular Precision Nephrology Core (MPNC), and support the Enrichment Program, Opportunity Pool Pilot and Feasibility Program, and two Research Projects. The Enrichment Program aims to equip the research base with additional skill sets and maximizes interactions and intellectual discourse within the PCEN. Initiatives within the Enrichment Program will encourage and support innovative multidisciplinary research in pediatric kidney disease through early career engagement, including the Summer Scholar program; career development and collaborations; and patient, family, and community engagement. The Opportunity Pool Pilot and Feasibility Programwill continue to stimulate and solicit new project ideas to address key barriers to research progress in pediatric nephrology, specifically for early stage investigators, new investigators, or established investigators not previously involved in research on pediatric kidney disease. The CHOP PCEN organizational structure includes oversight by an External Advisory Board (EAB) and input and guidance from a Scientific Advisory Committee (SAC). The Steering Committee will set overall policy for the CHOP PCEN and will include the Center Co-Directors, the SAC Chair, the Biomedical Core Directors and leadership, and the ProgramLeads. In addition to facilitating collaborations across the CHOP PCEN collaborators at CHOP, the University of Pennsylvania, and Johns Hopkins University, the Administrative Core will support interdisciplinary partnerships across the CHOP PCEN research base and the PCEN Network. Our team includes individuals with proven track records in mentoring, basic science, translational research, clinical investigation, epidemiology, informatics, and health services research. We will build upon the success of our established PCEN to expand the evidence base of observational data for clinical trial design and enhance the infrastructure for pragmatic clinical trials and comparative effectiveness through the LHS Core; facilitate the identification of novel therapeutic targets through the MPNC; foster collaboration in kidney disease research across other centers; and mentor members of the broader nephrology community by supporting the Enrichment Program, an Opportunity Pool Program, and innovative research projects in childhood kidney disease.