Mentoring of Early Career Researchers from Diverse Backgrounds

项目总结 迫切需要培养下一代科学家，促进这一劳动力的多样性，以提高 照顾患有肾脏疾病的儿童。在职业生涯早期阶段进行有效的指导是成功的基础 在生物医学研究方面的职业发展。NIDDK调查员奖的候选人将支持 来自不同背景的早期职业研究人员的导师是Michelle Denburg，医学博士，MSCE。Dr。 邓伯格是宾夕法尼亚大学佩雷尔曼分校儿科学和流行病学副教授 他是费城儿童医院的儿科肾科执业医师 (盖章)。PSOM和CHOP为协作、指导、教学培训和 在以患者为中心的研究中的机会，以及Denburg博士的领导角色和责任是高度 与该奖项的目标协同。Denburg博士的多学科研究计划专注于 管理儿童肾脏疾病的并发症并改善其健康结局，包括慢性肾脏疾病 肾脏疾病(CKD)、肾小球疾病和肾结石疾病，尤其对骨骼健康感兴趣 以及矿物质和维生素D代谢的改变。她的研究包括对大量电子健康记录的分析 数据库，现有NIDDK资助的前瞻性队列研究的辅助研究，以及观察性研究， 以患者为中心的转化性和干预性研究。Denburg博士有一个长期的和证明的 致力于研究和职业指导。在过去的12年里，Denburg博士指导了超过35名 来自多个学科、机构和职业阶段的不同背景的个人。大多数人 这些人继续了他们在学术医学方面的职业生涯，并继续从事研究。有了这个 获奖后，Denburg博士的目标是继续在严格以患者为本的行为中提供有效的指导 向来自不同背景的早期职业研究人员提供儿科研究，重点是招聘和 指导科学和医学中代表性不足的人群中的个人。登堡医生 将继续开展其他以证据为基础的培训计划，旨在加强和提高文化技能 有意识地指导来自不同背景的早期职业研究人员。她将发展可持续的指导 有助于更广泛的指导环境和扩大培训基础设施和资源的方法 在查普和宾夕法尼亚大学促进肾脏疾病的研究。登堡博士的长期职业目标是 跨学科临床和转化研究，改善儿童和青少年的健康和福祉 并催化来自不同背景的实习生的职业生涯，成为 肾脏疾病研究的独立调查人员。来自K26奖项的支持将帮助她保持积极 指导计划，并扩大她的指导能力，使她能够接受1-2名新的博士后指导对象 每年至少有一名博士后暑期学生参加拟议的奖项，重点是指导 在医学界代表性不足的个人。

PROJECT SUMMARY There is a critical need to train the next generation of scientists and promote diversity in this workforce to improve care for children with kidney disease. Effective mentoring at early career stages is fundamental to successful career advancement in biomedical research. The candidate for this NIDDK Investigator Award to Support Mentoring of Early Career Researchers from Diverse Backgrounds is Michelle Denburg, MD, MSCE. Dr. Denburg is an Associate Professor of Pediatrics and Epidemiology at the University of Pennsylvania Perelman School of Medicine (PSOM) and is a practicing pediatric nephrologist at the Children's Hospital of Philadelphia (CHOP). PSOM and CHOP offer an ideal setting for collaboration, mentorship, didactic training, and opportunities in patient-oriented research, and Dr. Denburg’s leadership roles and responsibilities are highly synergistic with the goals of this award. Dr. Denburg’s multidisciplinary research program is focused on managing complications of and improving health outcomes in childhood kidney diseases, including chronic kidney disease (CKD), glomerular disease, and kidney stone disease, with a particular interest in bone health and altered mineral and vitamin D metabolism. Her research includes analyses of large electronic health record databases, ancillary studies to existing NIDDK-funded prospective cohort studies, and observational, translational, and interventional patient-oriented studies. Dr. Denburg has a long-standing and demonstrated commitment to research and career mentoring. Over the past 12 years, Dr. Denburg has mentored over 35 individuals from diverse backgrounds across multiple disciplines, institutions, and career stages. The majority of these individuals have continued their careers in academic medicine and remain engaged in research. With this award, Dr. Denburg aims to continue to provide effective mentoring in the conduct of rigorous patient-oriented pediatric research to early career researchers from diverse backgrounds, with a focus on recruiting and mentoring individuals from populations that have been underrepresented in science and medicine. Dr. Denburg will pursue additional evidence-based training programs designed to reinforce and enhance skills in culturally aware mentoring of early career researchers from diverse backgrounds. She will develop sustainable mentoring approaches that contribute to the wider mentoring environment and expand training infrastructure and resources to promote research in kidney disease at CHOP and Penn. Dr. Denburg’s long-term career goals are to conduct interdisciplinary clinical and translational research that improves the health and well-being of children and young adults with kidney disease and to catalyze the careers of trainees from diverse backgrounds to become independent investigators in kidney disease research. Support from the K26 award will help sustain her active mentoring program and expand her mentoring capacity to enable her to take on 1-2 new postdoctoral mentees and at least one predoctoral summer student each year of the proposed award, with a focus on mentoring of individuals underrepresented in medicine.