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Sickle Cell Disease Stem Cell Repository

Sickle Cell Disease Stem Cell Repository
镰状细胞病干细胞储存库
批准号:
10018999
负责人:
JOHN P MANIS
金额:
$120.89万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-24 至 2024-09-30

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中文摘要
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英文摘要
We plan to recruit volunteers with SCD as healthy donors for collection of peripheral blood stem cells by apheresis. Volunteers will be treated with plerixafor, a drug that we and others have shown to mobilize peripheral blood (PB) CD34+ cells safely in SCD patients. The collected stem cells will be purified by magnetic separation using CD34 beads, validated, frozen, and then provided as a resource to investigators working on developing therapies for SCD.
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会议论文
Normalization of Sickle Cell Disease bone marrow niche defects by RBC transfusion
  • 批准号:
    10494383
  • 项目类别:
  • 资助金额:
    $85.85万
  • 财政年份:
    2022
  • 负责人:
    JOHN P MANIS
  • 依托单位:
Normalization of Sickle Cell Disease bone marrow niche defects by RBC transfusion
  • 批准号:
    10682593
  • 项目类别:
  • 资助金额:
    $85.85万
  • 财政年份:
    2022
  • 负责人:
    JOHN P MANIS
  • 依托单位:
Immune repertoire and function in typical and atypical SCID
  • 批准号:
    9027475
  • 项目类别:
  • 资助金额:
    $46.08万
  • 财政年份:
    2012
  • 负责人:
    JOHN P MANIS
  • 依托单位:
Murine Model of Job's syndrome
  • 批准号:
    8048542
  • 项目类别:
  • 资助金额:
    $24.65万
  • 财政年份:
    2011
  • 负责人:
    JOHN P MANIS
  • 依托单位:
海外基金