Sickle Cell Disease Stem Cell Repository
Sickle Cell Disease Stem Cell Repository
批准号:
10018999
负责人:
JOHN P MANIS
金额:
$120.89万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-24 至 2024-09-30
关键词:
Blood Component RemovalCD34 geneCellsCollectionFreezingInstitutional Review BoardsMagnetismPatientsPeripheral Blood Stem CellPharmaceutical PreparationsPhaseProtocols documentationResearch PersonnelResourcesShipsSickle Cell AnemiaStem cellsTraining and EducationValidationperipheral bloodrecruitrepositorytherapy developmentvolunteer
中文摘要
点击翻译按钮获取中文摘要
英文摘要
We plan to recruit volunteers with SCD as healthy donors for collection of peripheral blood stem
cells by apheresis. Volunteers will be treated with plerixafor, a drug that we and others have
shown to mobilize peripheral blood (PB) CD34+ cells safely in SCD patients. The collected
stem cells will be purified by magnetic separation using CD34 beads, validated, frozen, and then
provided as a resource to investigators working on developing therapies for SCD.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Normalization of Sickle Cell Disease bone marrow niche defects by RBC transfusion
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批准号:10494383
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项目类别:
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资助金额:$85.85万
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财政年份:2022
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负责人:JOHN P MANIS
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依托单位:
Normalization of Sickle Cell Disease bone marrow niche defects by RBC transfusion
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批准号:10682593
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项目类别:
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资助金额:$85.85万
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财政年份:2022
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负责人:JOHN P MANIS
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依托单位:
Immune repertoire and function in typical and atypical SCID
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批准号:9027475
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项目类别:
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资助金额:$46.08万
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财政年份:2012
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负责人:JOHN P MANIS
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依托单位:
Murine Model of Job's syndrome
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批准号:8048542
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项目类别:
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资助金额:$24.65万
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财政年份:2011
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负责人:JOHN P MANIS
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依托单位:
Murine Model of Job's syndrome
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批准号:8320852
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项目类别:
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资助金额:$20.58万
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财政年份:2011
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负责人:JOHN P MANIS
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依托单位:
Animal Core
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批准号:7798888
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项目类别:
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资助金额:$36.06万
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财政年份:2009
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负责人:JOHN P MANIS
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依托单位:
DNA Damage Responses in B Cell Development
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批准号:7589351
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项目类别:
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资助金额:$22.12万
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财政年份:2009
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负责人:JOHN P MANIS
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依托单位:
DNA Damage Responses in B Cell Development
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批准号:7749036
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项目类别:
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资助金额:$18.62万
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财政年份:2009
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负责人:JOHN P MANIS
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依托单位:
Transfusion Biology and Cellular Therapies
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批准号:10555517
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项目类别:
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资助金额:$65.42万
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财政年份:2001
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负责人:JOHN P MANIS
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依托单位:
CONTROL IG HEAVY CHAIN CLASS SWITCHING
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批准号:2057538
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项目类别:
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资助金额:$7.72万
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财政年份:1994
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负责人:JOHN P MANIS
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依托单位:
CONTROL IG HEAVY CHAIN CLASS SWITCHING
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批准号:2057537
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项目类别:
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资助金额:$7.72万
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财政年份:1994
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负责人:JOHN P MANIS
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依托单位:
CONTROL IG HEAVY CHAIN CLASS SWITCHING
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批准号:2633400
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项目类别:
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资助金额:$8.8万
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财政年份:1994
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负责人:JOHN P MANIS
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依托单位:
CONTROL IG HEAVY CHAIN CLASS SWITCHING
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批准号:2855893
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项目类别:
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资助金额:$8.8万
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财政年份:1994
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负责人:JOHN P MANIS
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依托单位:
CONTROL IG HEAVY CHAIN CLASS SWITCHING
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批准号:2002652
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项目类别:
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资助金额:$8.8万
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财政年份:1994
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负责人:JOHN P MANIS
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依托单位:
Animal Core
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批准号:8694075
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项目类别:
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资助金额:$35.68万
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财政年份:--
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负责人:JOHN P MANIS
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依托单位:
Animal Core
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批准号:9897588
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项目类别:
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资助金额:$33.72万
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财政年份:--
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负责人:JOHN P MANIS
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依托单位:
Animal Core
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批准号:8511793
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项目类别:
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资助金额:$34.71万
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财政年份:--
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负责人:JOHN P MANIS
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依托单位:
Animal Core
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批准号:8377030
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项目类别:
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资助金额:$36.57万
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财政年份:--
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负责人:JOHN P MANIS
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依托单位:
Animal Core
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批准号:8289605
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项目类别:
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资助金额:$36.3万
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财政年份:--
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负责人:JOHN P MANIS
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依托单位:
海外基金