Mathematical and Statistical Analysis Techniques for in Vivo Imaging Studies

我们已经完成并发表了用l -1- c -11亮氨酸和PET估算脑蛋白合成（rCPS）速率的精细数据分析方法。我们还完成了简化患者扫描方案影响的验证和发表。综上所述，c - 11亮氨酸PET方法的简化扫描方案，即扫描时间为60分钟，使用静脉校准的人口输入函数，可以用于高分辨率研究层析成像的c - 11亮氨酸研究，而不会影响rps测量的准确性。这种简化的扫描方案将在未来的所有研究中使用。

We have completed and published our refined data analysis methods for estimation of rates of cerebral protein synthesis (rCPS) with L-1-C-11leucine and PET. We also completed validation and publication of the impact of a simplified patient scanning protocol. Taken together these studies demonstrate that the simplified scanning protocol for the C-11leucine PET method, i.e., a scan time of 60 minutes and use of venous-calibrated population input functions, can be used in C-11leucine studies on the high resolution research tomograph without compromising accuracy of rCPS measurements. This simplified scanning protocol will be employed in all future studies.