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Microbiome analysis in a mouse model of Alzheimers Disease (AD)

Microbiome analysis in a mouse model of Alzheimers Disease (AD)
阿尔茨海默病 (AD) 小鼠模型中的微生物组分析
批准号：
10019246
负责人：
Myriam Gorospe
金额：
$13.52万
依托单位：
NATIONAL INSTITUTE ON AGING
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10019246
关键词：
AffectAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease modelBrainChronicCommunitiesDNAElderlyGenomeGoalsHealthHumanImmune systemInflammagingInflammatoryIntestinal permeabilityMusPatientsPrevotellaProcessProtocols documentationRibosomal RNASamplingSerumShapesStandardizationbacterial communitycytokinegut microbiomeinterestmetagenomemicrobialmicrobiomemicrobiome analysismicrobiotamouse model

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We have investigated microbiota community involved in mouse and human fecal samples and recently started working on the serum samples. The most abundant bacterial taxa identified in mouse fecal samples were Bacteroidales, Clostridiales, Lactobacillales, Verrucomicrobiales. Also, there was significant difference in the microbial abundance between 2 month and 48 old mice. We also analyzed 18 human fecal samples from BLSA and found the genus Prevotella was significantly lower in aging (AIM 1a,b) (LGG, TGB, LEPS). We are actively working on standardizing the protocol extract and sequence from CSF and brain in mice (AIM 1c). We are also currently working on the impact of gut microbiome on pro-inflammatory cytokines and intestinal permeability (AIM 2).
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