Biostatics

生物静力学

• 批准号: 10017941
• 负责人: Yimei Li
• 金额: $ 32.95万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-18 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10017941
• 关键词: Address; Applied Research; Biometry; Biostatistics Core; Clinical Research; Clinical Trials; Collaborations; Conduct Clinical Trials; Data; Enrollment; Ensure; Experimental Designs; Feasibility Studies; Goals; In Vitro; Laboratories; Methods; Modernization; Monitor; Neuroblastoma; Observational Study; Paper; Patient-Focused Outcomes; Patients; Play; Reporting; Reproducibility of Results; Research; Research Design; Resistance; Role; Science; Specimen; Statistical Data Interpretation; Statistical Methods; Techniques; Translational Research; base; computerized data processing; data integrity; data quality; database design; design; early phase clinical trial; experience; experimental analysis; experimental study; high risk; improved; improved outcome; in vivo; laboratory experiment; member; novel; patient safety; programs; success; translational study

SUMMARY/ABSTRACT The use of modern statistical methods, analytic techniques, data processing and database design is necessary in translational research in neuroblastoma (NB). The Biostatistics Core of this program project (PPG), which comprises biostatistical experts in clinical and translational study design and analysis, Dr. Susan Groshen (Core Director), Dr. Richard Sposto, and Dr. Yimei Li, and an experienced staff, will play the central role in fulfilling this requirement. The primary responsibility of the Biostatistics Core is to ensure that appropriate and efficient statistical designs and analyses are employed in the research. To this end, members of the Biostatistics Core will involve themselves in the design of laboratory experiments and clinical studies conducted during this program project. The Core will identify, adapt, or develop appropriate statistical design and analysis methods, will analyze data, produce coherent and complete reports of the results of these analyzes, and co-author papers reporting these results. In addition, the Biostatistics Core, collaborating with Core B, will play an important role in developing and conducting clinical trials undertaken based on the results of Projects 1 through 5, monitoring the safety of patients enrolled on these trials, and ensuring the quality and integrity of the data collected from these trials. Core C is essential to the overall success of the translational mandate of this Program.

摘要/摘要 需要使用现代统计方法、分析技术、数据处理和数据库设计 神经母细胞瘤（NB）的转化研究。该计划项目（PPG）的生物统计核心， 由临床和转化研究设计和分析方面的生物统计学专家 Susan Groshen 博士组成 （核心主任）Richard Sposto 博士和李一梅博士以及经验丰富的工作人员将在该项目中发挥核心作用 满足这个要求。生物统计核心的主要职责是确保适当和 研究中采用了有效的统计设计和分析。为此，委员会成员 生物统计核心将参与实验室实验和临床研究的设计 在此计划项目期间进行。核心将识别、调整或开发适当的统计设计 和分析方法，将分析数据，生成连贯且完整的结果报告 分析，以及报告这些结果的合著者论文。此外，生物统计核心与 核心B，将在开发和开展基于结果的临床试验中发挥重要作用 项目 1 至 5，监测参加这些试验的患者的安全性，并确保质量和 从这些试验中收集的数据的完整性。核心 C 对于转化的整体成功至关重要 本计划的任务。