Biostatics

生物静力学

• 批准号: 10265477
• 负责人: Yimei Li
• 金额: $ 31.36万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-18 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10265477
• 关键词: Address; Applied Research; Biometry; Biostatistics Core; Clinical Research; Clinical Trials; Collaborations; Conduct Clinical Trials; Data; Enrollment; Ensure; Experimental Designs; Feasibility Studies; Goals; In Vitro; Laboratories; Methods; Modernization; Monitor; Neuroblastoma; Observational Study; Paper; Patient-Focused Outcomes; Patients; Play; Reporting; Reproducibility of Results; Research; Research Design; Resistance; Role; Science; Specimen; Statistical Data Interpretation; Statistical Methods; Techniques; Translational Research; base; computerized data processing; data integrity; data quality; database design; design; early phase clinical trial; experience; experimental analysis; experimental study; high risk; improved; improved outcome; in vivo; laboratory experiment; member; novel; patient safety; programs; success; translational study

SUMMARY/ABSTRACT The use of modern statistical methods, analytic techniques, data processing and database design is necessary in translational research in neuroblastoma (NB). The Biostatistics Core of this program project (PPG), which comprises biostatistical experts in clinical and translational study design and analysis, Dr. Susan Groshen (Core Director), Dr. Richard Sposto, and Dr. Yimei Li, and an experienced staff, will play the central role in fulfilling this requirement. The primary responsibility of the Biostatistics Core is to ensure that appropriate and efficient statistical designs and analyses are employed in the research. To this end, members of the Biostatistics Core will involve themselves in the design of laboratory experiments and clinical studies conducted during this program project. The Core will identify, adapt, or develop appropriate statistical design and analysis methods, will analyze data, produce coherent and complete reports of the results of these analyzes, and co-author papers reporting these results. In addition, the Biostatistics Core, collaborating with Core B, will play an important role in developing and conducting clinical trials undertaken based on the results of Projects 1 through 5, monitoring the safety of patients enrolled on these trials, and ensuring the quality and integrity of the data collected from these trials. Core C is essential to the overall success of the translational mandate of this Program.

总结/摘要 必须使用现代统计方法、分析技术、数据处理和数据库设计 神经母细胞瘤（NB）的转化研究。该项目的生物统计学核心（PPG）， 包括临床和转化研究设计和分析方面的生物统计学专家Susan Groshen博士 (Core主任）、Richard Sposto博士和Yimei Li博士以及经验丰富的工作人员将在以下方面发挥核心作用： 满足这一要求。生物统计学核心的主要责任是确保适当和 研究采用了有效的统计设计和分析。为此， 生物统计学核心将参与实验室实验和临床研究的设计 在这个项目的过程中。核心将确定、调整或开发适当的统计设计 和分析方法，将分析数据，产生连贯和完整的报告，这些结果 分析，并共同撰写报告这些结果的论文。此外，生物统计学核心，与 核心B，将在开发和开展基于结果的临床试验中发挥重要作用 项目1至项目5，监测参加这些试验的患者的安全性，并确保质量和 从这些试验中收集的数据的完整性。核心C对翻译的整体成功至关重要。 这个方案的任务。