Topic 393: Integrated Photonic Biosensor for Precision Oncology Dose Measurements

放射治疗是广泛应用于多种恶性肿瘤的一种主要治疗方法。然而，物理剂量测量是 不是一个有效的方法，因为不同患者甚至不同类型的癌症的生物反应是非常 对于相同的物理剂量不同。此外，病变组织和正常器官对辐射的敏感性也不同。 现有的医疗设备(物理剂量计)不能满足评估生物对辐射反应的所有标准。 治疗，尤指以临终关怀的方式。IFOS和斯坦福大学正在开发一种快速、便携、易于使用的 以及定量剂量测量方法--包括便携式手持式传感器和新型纳米探针，用于快速、 癌组织的实时原位成像。该探头被设计用来检测活性氧和氮物种。 由于辐射和带电粒子治疗而产生的。这项创新将提供极大的增强成像 提高肿瘤学家在放射治疗监测方面的能力。

Radiation therapy is a widely used primary treatment for multiple malignancies. However, physical dose measurement is not an effective approach as the biological response of different patients or even different types of cancers are very different for the same physical dose. Moreover, diseased tissue and normal organ radiation sensitivities also vary. Existing medical devices (physical dosimeters) do not satisfy all the metrics for assessing biological response to radiation therapy, especially in a point-of-care manner. IFOS and Stanford University are developing a rapid, portable, easy-to-use and quantitative dose measurement method – comprising a portable handheld sensor and a novel nanoprobe for rapid, real-time in-situ imaging of cancerous tissue. The probe is designed to detect Reactive Oxygen and Nitrogen Species (RONS) generated due to radiation and charge particle therapy. The innovation will provide greatly enhanced imaging capabilities to oncologists in radiation treatment monitoring.