IMMUNE EPITOPE AND ANALYSIS PROGRAM: Infectious Diseases

免疫表位和分析程序：传染病

• 批准号: 10021121
• 负责人: ALESSANDRO SETTE
• 金额: $ 250.62万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-15 至 2025-12-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10021121
• 关键词: 3-Dimensional; Allergens; Alloantigen; Antibodies; Antigens; Area; Attention; Autoantigens; Communicable Diseases; Communities; Contractor; Contracts; Databases; Development; Epitope Mapping; Epitopes; Frequencies; HIV; Imagery; Immune; Link; Literature; Mission; Modeling; National Institute of Allergy and Infectious Disease; Online Systems; Proteins; Publishing; Resources; Series; Structural Protein; T-Lymphocyte Epitopes; Toxin; analytical tool; improved; pathogen; prediction algorithm; programs; protein structure; relational database; tool; web site

The Immune Epitope Database and Analysis Program contains extensively curated antibody and T cell epitope information from the published literature and NIAID epitope discovery contractors, as well as tools to predict antibody and T cell epitopes or visualization/mapping of epitopes onto known protein structures. Over 20,500 references have been curated into the IEDB, which includes epitopes for pathogens in NIAID’s mission area, with the exception of HIV. In addition, the IEDB hosts a series of epitope analysis tools such as antibody and T cell epitope prediction algorithms, epitope homology discovery, HLA frequency analysis, and 3D epitope viewer/protein mapping tools.

免疫表位数据库和分析程序包含来自已发表文献和NIAID表位发现承包商的广泛策划的抗体和T细胞表位信息，以及预测抗体和T细胞表位或将表位可视化/映射到已知蛋白质结构上的工具。超过20，500个参考文献已被整理到IEDB中，其中包括NIAID使命领域中病原体的表位，但艾滋病毒除外。 此外，IEDB还拥有一系列表位分析工具，如抗体和T细胞表位预测算法、表位同源性发现、HLA频率分析和3D表位查看器/蛋白质作图工具。